Lewis J Rubin

Author:

Lewis J. Rubin

ISBN #:

0340807822

Author:

Lewis J. Rubin

ISBN #:

0824795059

Author:

Lewis J. Rubin

ISBN #:

0898386322

US Patent:

20080118497, May 22, 2008

Filed:

Jan 17, 2006

Appl. No.:

11/814038

Inventors:

Carmelle Remillard - San Diego CA, US
Lewis J. Rubin - La Jolla CA, US
Ying Yu - Lake Forest CA, US
Jason X.J. Yuan - San Diego CA, US

International Classification:

C12Q 1/68
A61K 39/395
A61K 31/7088
A61K 38/02
C07H 21/02
C12N 15/63
C12N 15/11
C07K 16/00
C07K 2/00
G01N 33/53

US Classification:

4241301, 435 6, 514 44, 514 2, 536 245, 5303871, 5303881, 4353201, 436501

Abstract:

The present invention relates to compositions related to a polynucleotide encoding a transient receptor potential cation gene. Also disclosed is the use of this polynucleotide, its homologs, fragments, variants and its resultant polypeptides in the diagnosis, prevention and treatment of disease, particularly idiopathic pulmonary arterial hypertension (IPAH). This invention also teaches the use of these polynucleotides and polypeptides as assays for drug discovery and therapies.

US Patent:

20130309328, Nov 21, 2013

Filed:

Jan 7, 2013

Appl. No.:

13/735558

Inventors:

GeNO LLC - , US
Robert F. Roscigno - Melbourne Beach FL, US
David H. Fine - Cocoa Beach FL, US
Lewis J. Rubin - La Jolla CA, US

International Classification:

A61B 5/026
A61K 33/00
A61M 16/12

US Classification:

424718, 600508, 12820312

Abstract:

A method for treating pulmonary arterial hypertension in a patient can include determining whether a patient with pulmonary arterial hypertension has an enlarged right ventricle or right ventricular dysfunction, where the patient has previously been administered a prostanoid and weaning the patient off of the prostanoid if the patient does not have an enlarged right ventricle or right ventricular dysfunction.

US Patent:

20220323459, Oct 13, 2022

Filed:

May 16, 2022

Appl. No.:

17/745333

Inventors:

- Silver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas SCHMEHL - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/557
A61K 9/00
A61K 31/192

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

US Patent:

20220218720, Jul 14, 2022

Filed:

Mar 29, 2022

Appl. No.:

17/707651

Inventors:

- Silver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas SCHMEHL - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/557
A61K 9/00
A61K 31/192

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

US Patent:

20230062605, Mar 2, 2023

Filed:

Oct 17, 2022

Appl. No.:

17/967255

Inventors:

- Silver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas SCHMEHL - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/557
A61K 31/192
A61K 9/00

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

US Patent:

20200171044, Jun 4, 2020

Filed:

Jan 31, 2020

Appl. No.:

16/778662

Inventors:

- Siliver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas Schmehl - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/557
A61K 9/00
A61K 31/192

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

US Patent:

20190365778, Dec 5, 2019

Filed:

Aug 9, 2019

Appl. No.:

16/536954

Inventors:

- Silver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas SCHMEHL - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/557
A61K 9/00
A61K 31/192

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.

US Patent:

20160143868, May 26, 2016

Filed:

Feb 1, 2016

Appl. No.:

15/011999

Inventors:

- Silver Spring MD, US
Robert ROSCIGNO - Chapel Hill NC, US
Lewis J. RUBIN - LaJolla CA, US
Thomas SCHMEHL - Giessen, DE
Werner SEEGER - Giessen, DE
Carl STERRITT - Weybridge, GB
Robert VOSWINCKEL - Giessen, DE

Assignee:

United Therapeutics Corporation - Silver Spring MD

International Classification:

A61K 31/192
A61K 9/00

Abstract:

Treprostinil can be administered using a metered dose inhaler. Such administration provides a greater degree of autonomy to patients. Also disclosed are kits that include a metered dose inhaler containing a pharmaceutical formulation containing treprostinil.