Lewis J Noe

US Patent:

6573107, Jun 3, 2003

Filed:

Feb 26, 1999

Appl. No.:

09/259810

Inventors:

John M. Bowen - Laramie WY
Lewis J. Noe - Laramie WY
B. Patrick Sullivan - Laramie WY

Assignee:

The University of Wyoming - Laramie WY

International Classification:

G01N 33543

US Classification:

436518, 356317, 356318, 356244, 422 57, 422 8205, 422 8211, 422 83, 422 93, 4352871, 4352872, 4352883, 4352887, 435807, 435808, 436164, 436165, 436524, 436525, 436527, 436805

Abstract:

The biosensor involves a specially designed surface which can be optically coupled to a Surface Plasmon Resonance spectrometer. The key components of the biosensor are a bimetallic layer, a self assembled monolayer of chemicals and a layer of biomolecules such as special antibodies. The innovative bimetallic layer combines the sensitivity of silver metal and durability of gold and thus make it an ideal biosensor layer not only for a low volatility gas phase detection but also for a liquid phase detection. The successful application of the biosensor in high explosive substance detection proves that the biosensor is a sensitive and highly specific device for security and anti-terrorism applications, when it is combined with a Surface Plasmon Resonance Spectroscope.

US Patent:

48027618, Feb 7, 1989

Filed:

Aug 31, 1987

Appl. No.:

7/093093

Inventors:

John M. Bowen - Laramie WY
Patrick J. Sullivan - Laramie WY
M. Sterling Blanche - Laramie WY
Michael Essington - Laramie WY
Lewis J. Noe - Laramie WY

Assignee:

Western Research Institute - Laramie WY

International Classification:

G01J 344
G01N 110

US Classification:

356301

Abstract:

Method and apparatus are provided for remote in-situ detection and/or monitoring of selected compounds in liquid or gaseous media using one of several methods of Raman spectroscopy. The resulting Raman signal is conducted through optical fibers for recording a Raman spectrum at a distance from the instrument.