Lester A Dolak from 12520 Kelly Greens Blvd APT 353, Fort Myers, FL 33908, age 83

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Biologically Pure Culture Of Nocardiopsis Trehalosei Sp. Nov.
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US Patent:

43060285, Dec 15, 1981
Filed:

Oct 9, 1980
Appl. No.:

6/195562
Inventors:

Lester A. Dolak - Plainwell MI
Alice L. Laborde - Kalamazoo MI
Thomas M. Castle - Portage MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

C12N 120
US Classification:

435253
Abstract:

Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov. , NRRL 12026. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria. Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##.

Composition Of Matter And Process
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US Patent:

45656991, Jan 21, 1986
Filed:

Jul 18, 1983
Appl. No.:

6/515077
Inventors:

Lester A. Dolak - Plainwell MI
Alice L. Laborde - Kalamazoo MI
Oldrich K. Sebek - Kalamazoo MI
Thomas M. Castle - Kalamazoo MI
Thomas F. Brodasky - Kalamazoo MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

A61K 3574
C12D 106
C07D33332
US Classification:

424117
Abstract:

Novel antibiotic U-68,204 is produced in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces thiolactonus, NRRL 15439. This antibiotic is active against various Gram-positive bacteria. Thus, antibiotic U-68,204 can be used in various environments to eradicate or control such bacteria.

Composition Of Matter And Process
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US Patent:

43060218, Dec 15, 1981
Filed:

Apr 10, 1980
Appl. No.:

6/139099
Inventors:

Lester A. Dolak - Plainwell MI
LeRoy E. Johnson - Kalamazoo MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

C12N 120
C12P 1300
C12P 106
US Classification:

435128
Abstract:

Novel antibiotic U-60, 394 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces woolenses, Dietz and Li sp. n. , NRRL 12113. This antibiotic is strongly active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus hemolyticus. It is also strongly active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-60, 394 can be used in various environments to eradicate or control such bacteria.

Process For Producing 4-Thiouracil
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US Patent:

40100758, Mar 1, 1977
Filed:

May 24, 1976
Appl. No.:

5/689376
Inventors:

John H. Coats - Kalamazoo MI
Alma Dietz - Kalamazoo MI
Lester A. Dolak - Plainwell MI
Oldrich K. Sebek - Kalamazoo MI
Walter T. Sokolski - Kalamazoo MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

C12D 900
US Classification:

195 80R
Abstract:

A novel microbiological process for preparing 4-thiouracil, a known and useful compound. The compound is produced by the controlled fermentation of the new microorganism Streptomyces libani subsp. soldani, NRRL 8173, and its strains W and P having the NRRL designations NRRL 8174 and NRRL 8175, respectively.

Composition Of Matter And Process
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US Patent:

41138554, Sep 12, 1978
Filed:

Sep 19, 1977
Appl. No.:

5/834285
Inventors:

Clarence DeBoer - Kalamazoo MI
Lester A. Dolak - Plainwell MI
Durey H. Peterson - Kalamazoo MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

A61K 3500
US Classification:

424117
Abstract:

Novel antibiotic formulations of antibiotic 354 (U-54,703) and their use in treating susceptible infectious disease in humans and animals.

3-Trehalosamine Compounds
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US Patent:

42764122, Jun 30, 1981
Filed:

Sep 17, 1979
Appl. No.:

6/076489
Inventors:

Lester A. Dolak - Plainwell MI
Alice L. Laborde - Kalamazoo MI
Thomas M. Castle - Portage MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

A61K 3171
C07H 506
US Classification:

536 17R
Abstract:

Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov. , NRRL 12026. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria. Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##.

Antibiotic 354 And Process For Producing Same
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US Patent:

41361717, Jan 23, 1979
Filed:

Sep 19, 1977
Appl. No.:

5/834286
Inventors:

Clarence De Boer - Kalamazoo MI
Lester A. Dolak - Plainwell MI
Durey H. Peterson - Kalamazoo MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

A61K 3500
US Classification:

424117
Abstract:

Novel antibiotic 354 (U-54,703) producible in a fermentation under controlled conditions using the new microorganism Streptomyces puniceus subsp. doliceus, NRRL 11160. This antibiotic is active against Gram-negative bacteria, for example, Pseudomonas and Proteus species. Thus, antibiotic 354 can be used in various environments to eradicate or control such bacteria.

Process Of Producing 3-Trehalosamine By Fermentation
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US Patent:

43106277, Jan 12, 1982
Filed:

Oct 9, 1980
Appl. No.:

6/195561
Inventors:

Lester A. Dolak - Plainwell MI
Alice L. Laborde - Kalamazoo MI
Thomas M. Castle - Portage MI
Assignee:

The Upjohn Company - Kalamazoo MI
International Classification:

C12P 1926
US Classification:

435 84
Abstract:

Novel antibiotic 3-trehalosamine (U-59,834) producible in a fermentation under controlled conditions using the new microorganism Nocardiopsis trehalosei sp. nov. , NRRL 12026. This antibiotic is active against Gram-positive bacteria, for example, Staphylococcus aureus, Bacillus subtilis, and Diplococcus pneumoniae. Thus, 3-trehalosamine can be used in various environments to eradicate or control such bacteria. Antibiotic 3-trehalosamine can be shown by the following structural formula: ##STR1##.

Lester A Dolak