Leroy M Worth

US Patent:

58587543, Jan 12, 1999

Filed:

Feb 13, 1996

Appl. No.:

8/600450

Inventors:

Paul L. Modrich - Chapel Hill NC
Shin-San Su - Newton MA
Karin G. Au - Durham NC
Robert S. Lahue - Northboro MA
Deani Lee Cooper - Watertown MA
Leroy Worth - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C12N 914
C12N 906

US Classification:

435195

Abstract:

A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.

US Patent:

55567509, Sep 17, 1996

Filed:

Nov 1, 1993

Appl. No.:

8/145837

Inventors:

Paul L. Modrich - Chapel Hill NC
Shin-San Su - Newton MA
Karin G. Au - Durham NC
Robert S. Lahue - Northboro MA
Deani L. Cooper - Watertown MA
Leroy Worth - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C12Q 168
C12P 1934

US Classification:

435 6

Abstract:

A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.

US Patent:

56795220, Oct 21, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/459409

Inventors:

Paul L. Modrich - Chapel Hill NC
Shin-San Su - Newton MA
Karin G. Au - Durham NC
Robert S. Lahue - Northboro MA
Deani Lee Cooper - Watertown MA
Leroy Worth - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C12Q 168
C12Q 170
C12P 1934
C07H 2104

US Classification:

435 6

Abstract:

A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.

US Patent:

57028940, Dec 30, 1997

Filed:

Jun 2, 1995

Appl. No.:

8/460663

Inventors:

Paul L. Modrich - Chapel Hill NC
Shin-San Su - Newton MA
Karin G. Au - Durham NC
Robert S. Lahue - Northboro MA
Deani Lee Cooper - Watertown MA
Leroy Worth - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.

US Patent:

58614826, Jan 19, 1999

Filed:

Jun 2, 1995

Appl. No.:

8/458733

Inventors:

Paul L. Modrich - Chapel Hill NC
Shin-San Su - Newton MA
Karin G. Au - Durham NC
Robert S. Lahue - Northboro MA
Deani Lee Cooper - Watertown MA
Leroy Worth - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

C07K 14245

US Classification:

530350

Abstract:

A diagnostic method for detecting a base pair mismatch in a DNA duplex, comprising the steps of contacting at least one strand of a first DNA molecule with the complementary strand of a second DNA molecule under conditions such that base pairing occurs contacting a DNA duplex potentially containing a base pair mismatch with a mispair recognition protein under conditions suitable for the protein to form a specific complex only with the DNA duplex having a base pair mismatch, and not with a DNA duplex lacking a base pair mismatch, and detecting any complex as a measure of the presence of a base pair mismatch in the DNA duplex.