Leonard J Barbour

US Patent:

7132571, Nov 7, 2006

Filed:

May 9, 2002

Appl. No.:

10/141733

Inventors:

Jerry L. Atwood - Columbia MO, US
Leonard J. Barbour - Columbia MO, US
Agoston Jerga - Columbia MO, US

Assignee:

The Curators of the University of Missouri - Columbia MO

International Classification:

C07C 211/00

US Classification:

564308, 564306, 564307

Abstract:

A guest-host assembly having a generally spheroidal host assembly formed of trimers of calixarene molecules in a hexagonal close-packed assembly and its preparation. The calixarene trimers are associated together predominantly by van der Waals forces to provide dilated channels having void volumes within the range of 100-200 Å. A guest component, such as hydrogen, methane, or another hydrocarbon or halocarbon, is encapsulated within the dilated channels of the spheroidal host assembly and retained within the channels primarily by van der Waals forces. The guest-host assembly is stable at a temperature of 150 C. or higher. The temperature at which the onset of the release of the guest component occurs is within the range of 150-300 C.

US Patent:

7217846, May 15, 2007

Filed:

Oct 31, 2002

Appl. No.:

10/286179

Inventors:

Jerry L. Atwood - Columbia MO, US
Leonard J. Barbour - Columbia MO, US
Agoston Jerga - Columbia MO, US

International Classification:

C07C 39/12

US Classification:

568719

Abstract:

A guest host assembly comprising a host assembly formed of calixarene molecules and a guest component located within the host assembly. A crystallographic assembly of layers of the calixarene molecules and stacked along the crystallographic c axis of the assembly in a repeating configuration associated together predominantly by van der Waal forces. The guest component is transferable through the host assembly in a direction normal to the stacked layers. The calixarene molecules are configured in bilayers of adjacent layers along the c axis. The bilayers are shifted along the a or b axis so the assembly, relative to a corresponding assembly of the calixarene molecules without the inclusion of the guest component is shifted. The calixarene are calix(N)arenes in which N is an integer within the range of 4–8. The calixarene molecules are distally substituted with a substituent such as methyl, ethyl, propyl, butyl amyl or phenyl groups.

US Patent:

6495669, Dec 17, 2002

Filed:

Aug 11, 2000

Appl. No.:

09/637221

Inventors:

Jerry L. Atwood - Columbia MO
G. William Orr - Northfield MN
Leonard J. Barbour - Columbia MO

Assignee:

The Curators of the University of Missouri - Columbia MO

International Classification:

C07F 1300

US Classification:

534 14, 534 10, 534 15

Abstract:

Amphiphilic, polyhedron-shaped p-sulfonatocalix[4]arene building blocks, which have been shown previously to assemble into bilayers in an antiparallel fashion, assemble in a parallel alignment into spherical and helical tubular structures on the addition of pyridine N-oxide and lanthanide ions. The addition of greater amounts of pyridine N-oxide changed the curvature of the assembling surface and led to the formation of extended tubules. The inventive compositions and methods are useful for drug delivery and construction of nano-devices.