Leon P Lack

Author:

Leon Colburn Lack

ISBN #:

9027976449

US Patent:

43966152, Aug 2, 1983

Filed:

Jun 24, 1981

Appl. No.:

6/278373

Inventors:

Vladimir Petrow - Chapel Hill NC
Leon Lack - Durham NC

Assignee:

Duke University - Durham NC

International Classification:

A61K 3156

US Classification:

424242

Abstract:

A method of treating androgen-related disorders in an animal which comprises administering to the animal dihydrotestosterone level decreasing amounts of a compound of formula (I): ##STR1## wherein R is H or F; R. sup. 1 is selected from the group consisting of --H; straight or branched chain lower alkyl; hydroxyl; --OCOR. sup. 3 ; and O--(C. sub. 1 -C. sub. 6 alkyl); wherein R. sup. 3 is --H, C. sub. 1 -C. sub. 10 straight or branched chain alkyl group, phenyl, phenyl alkylene having straight or branched chain C. sub. 1 -C. sub. 6 alkylene, C. sub. 5 -C. sub. 10 cycloalkyl or C. sub. 6 -C. sub. 10 cycloalkyl alkylene; R. sup. 2 is H. sub. 2, methylene, ethylidene,. alpha. -CH. sub. 3 (H),. beta. -CH. sub. 3 (H),. alpha. -(OH)(H) or the acetonide derived from the 16. alpha. ,17. alpha. -dihydroxy derivative, and n is 1 or 2.