Lendell L Cummins from 4828 Echo Hill Ln, Del Mar, CA 92014, age 71, Phone: 858 461-4924

Method For Rapid Purification Of Nucleic Acids For Subsequent Analysis By Mass Spectrometry By Solution Capture
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US Patent:

7964343, Jun 21, 2011
Filed:

May 12, 2004
Appl. No.:

10/844938
Inventors:

Steven A. Hofstadler - Oceanside CA, US
Lendell L. Cummins - San Diego CA, US
Assignee:

Ibis Biosciences, Inc. - Carlsbad CA
International Classification:

C12Q 1/68
C07H 21/04
US Classification:

435 6, 536 231
Abstract:

The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.

Methods For Rapid Purification Of Nucleic Acids For Subsequent Analysis By Mass Spectrometry By Solution Capture
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US Patent:

8158354, Apr 17, 2012
Filed:

Sep 17, 2004
Appl. No.:

10/943344
Inventors:

Steven A. Hofstadler - Vista CA, US
Lendell L. Cummins - San Diego CA, US
Assignee:

Ibis Biosciences, Inc. - Carlsbad CA
International Classification:

C12Q 1/68
C07H 21/04
US Classification:

435 612, 536 231
Abstract:

The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.

Methods For Rapid Purification Of Nucleic Acids For Subsequent Analysis By Mass Spectrometry By Solution Capture
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US Patent:

8476415, Jul 2, 2013
Filed:

Apr 16, 2012
Appl. No.:

13/447623
Inventors:

Steven A. Hofstadler - Vista CA, US
Lendell L. Cummins - San Diego CA, US
Assignee:

Ibis Biosciences, Inc. - Carlsbad CA
International Classification:

C07H 21/02
C12Q 1/68
C07H 21/04
US Classification:

536 221, 435 6, 536 231
Abstract:

The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.

Method For Rapid Identification Of Molecules With Functional Activity Towards Biomolecular Targets
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US Patent:

20050095622, May 5, 2005
Filed:

Aug 20, 2004
Appl. No.:

10/922739
Inventors:

Steven Hofstadler - Oceanside CA, US
Lendell Cummins - San Diego CA, US
International Classification:

C12Q001/68
US Classification:

435006000
Abstract:

The present invention provides mass spectrometry-based methods for high throughput identification of molecules with functional activities such as nuclease, protease, reductase, kinase, phosphatase, or transferase activities towards biomolecular targets. These methods are useful for screening biological samples such as extracts, broths, lysates and natural product mixtures and provide valuable insights into biomolecular interactions of various biological ligands with biomolecular targets.

Method For Rapid Identification Of Molecules With Functional Activity Towards Biomolecular Targets
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US Patent:

20070264661, Nov 15, 2007
Filed:

Jul 6, 2007
Appl. No.:

11/774463
Inventors:

Steven Hofstadler - Vista CA, US
Lendell Cummins - San Diego CA, US
Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:

C12Q 1/68
G01N 33/53
G01N 33/573
US Classification:

435006000, 435007100, 435007400
Abstract:

The present invention provides mass spectrometry-based methods for high throughput identification of molecules with functional activities such as nuclease, protease, reductase, kinase, phosphatase, or transferase activities towards biomolecular targets. These methods are useful for screening biological samples such as extracts, broths, lysates and natural product mixtures and provide valuable insights into biomolecular interactions of various biological ligands with biomolecular targets.

Reagents For Nucleic Acid Purification
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US Patent:

20100190240, Jul 29, 2010
Filed:

Mar 21, 2008
Appl. No.:

12/532344
Inventors:

Yun Jiang - Carlsbad CA, US
Lendell L. Cummins - San Diego CA, US
Steven A. Hofstadler - Vista CA, US
International Classification:

C12N 1/08
C07H 21/00
C07H 21/02
C07H 21/04
US Classification:

435270, 536 2541, 536 2542, 536 231
Abstract:

Embodiments of the present invention provide methods and kits for purifying nucleic acids. In particular, embodiments of the present invention provide methods and kits for purifying nucleic acids through the use of magnetic particles in binding buffers.

Fungal Nucleic Acid Extraction
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US Patent:

20130323815, Dec 5, 2013
Filed:

Sep 23, 2011
Appl. No.:

13/876144
Inventors:

Gerard Gundling - Lake Forest IL, US
Thomas Laffler - Vista CA, US
Cristina A. Ivy - San Jose CA, US
Lendell Cummins - San Diego CA, US
Assignee:

IBIS BIOSCIENCES, INC. - Carlsbad CA
International Classification:

C12N 15/10
US Classification:

435209, 435270, 435220, 4353061
Abstract:

The invention provides methods for extraction of fungal (e.g., yeast spp., filamentous fungal spp.) nucleic acid (e.g., DNA, RNA) from a sample (e.g., be human or veterinary clinical or research samples, agricultural samples, agricultural commodity samples, food products, or environmental samples). In some embodiments, the present invention provides enhanced nucleic acid extraction from samples comprising fungal cell(s) wherein enzymatic (e.g., lysostaphin treatment, lyticase treatment) sample treatment is performed in combination with mechanical (e.g., bead beating) sample treatment.

Capillary Electrophoretic Detection Of Nucleic Acids
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US Patent:

58742131, Feb 23, 1999
Filed:

Jun 6, 1995
Appl. No.:

8/469852
Inventors:

Lendell L. Cummins - San Diego CA
Susan M. Freier - San Diego CA
Richard Griffey - San Marcos CA
G. Susan Srivatsa - San Diego CA
Assignee:

Isis Pharmacueticals, Inc. - Carlsbad CA
International Classification:

C12Q 168
US Classification:

435 6
Abstract:

Methods are provided for detection and quantitation of mixtures containing target nucleobase sequences using capillary electrophoresis. Peptide nucleic acid oligomers, complementary to the target sequences and preferably having appended detectable labels, are hybridized to the targets. Capillary electrophoresis is then performed, and the detectable label is detected and quantitated.

Lendell L Cummins