Lawrence Dominic Piro

US Patent:

55103367, Apr 23, 1996

Filed:

Sep 6, 1994

Appl. No.:

8/301243

Inventors:

Alan Saven - San Diego CA
Lawrence D. Piro - La Jolla CA

International Classification:

A61K 3170

US Classification:

514 46

Abstract:

An improved method for treating Class I histiocytosis, Langerhans cell histiocytosis, is disclosed. In accordance with that method, a therapeutically effective amount of a 2-halo-2'-deoxyadenosine is administered to a host mammal such as a human patient having histiocytosis in an amount of about 0. 5 to 0. 9 mg/kg of body weight over a course of about 5 to 9 days for up to two courses.

US Patent:

54766591, Dec 19, 1995

Filed:

Nov 12, 1993

Appl. No.:

8/151142

Inventors:

Michael G. Goodman - Rancho Santa Fe CA
Lawrence D. Piro - La Jolla CA

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 3939
A61K 3170
C12N 506
C12N 508

US Classification:

4242781

Abstract:

Processes for the killing of cancerous B cells, and particularly chronic lymphocytic leukemia (CLL) cells are disclosed. In one process, cancerous B cells that do not proliferate when contacted with an immune response-enhancing agent are contacted with an amount of such an agent sufficient to cause peripheral CLL cells to undergo blast transformation and proliferation. The contacted cells are then maintained for a time period sufficient for them to die from that contact. Further contacting of those cells with a cytotoxic amount of an anti-cancer drug or cytotoxic conjugate enhances the death of those cancer cells. In another process, peripheral CLL cells that proliferate on contact with an immune response-enhancing-agent are contacted with a proliferation-inducing amount of such an agent. The contacted cells are maintained for a time period sufficient to undergo blast transformation and proliferation, and the blasts are then contacted with a cytotoxic amount of an anti-cancer drug or cytotoxic conjugate and maintained.

US Patent:

54242967, Jun 13, 1995

Filed:

Apr 15, 1993

Appl. No.:

8/048111

Inventors:

Alan Saven - San Diego CA
Lawrence D. Piro - La Jolla CA

Assignee:

The Scripps Research Institute - La Jolla CA

International Classification:

A61K 3170

US Classification:

514 46

Abstract:

A process for the treatment of malignant astrocytoma in mammals is disclosed that utilizes a 2-halo-2'-deoxyadenosine derivative as the active treating agent.