Lawrence S Chan

US Patent:

8450350, May 28, 2013

Filed:

May 5, 2011

Appl. No.:

13/101970

Inventors:

Adilah Bahadoor - Cambridge MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Thomas T. Tibbitts - Westford MA, US

Assignee:

Infinity Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/41
A61K 31/4192
C07D 249/00
C07D 249/06

US Classification:

514359, 548255

Abstract:

Provided herein are triazole FASN inhibitors of the formula (I):Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

US Patent:

8546432, Oct 1, 2013

Filed:

May 5, 2011

Appl. No.:

13/101978

Inventors:

Adilah Bahadoor - Cambridge MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Gregg F. Keaney - Lexington MA, US
Marta Nevalainen - Weymouth MA, US
Vesa Nevalainen - Weymouth MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US

Assignee:

Infinity Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/41
C07D 249/00

US Classification:

514381, 548250

Abstract:

Provided herein are tetrazolone FASN inhibitors of the formula (I):Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

US Patent:

20010024798, Sep 27, 2001

Filed:

Apr 19, 2001

Appl. No.:

09/838760

Inventors:

Matthew Shair - Boston MA, US
Craig Lindsley - Ann Arbor MI, US
Henry Pelish - Silver Spring MD, US
Scott Sheehan - Needham MA, US
Brian Goess - Cambridge MA, US
Mark Layton - North Cambridge MA, US
Lawrence Chan - Cambridge MA, US
Chuo Chen - Cambridge MA, US
Nicholas Westwood - Brookline MA, US

International Classification:

G01N033/53
C07D241/04

US Classification:

435/007100, 544/385000

Abstract:

The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n.] ring systems, medium ring systems, and fused ring systems. In addition to compounds, libraries and methods for their production, the present invention also provides pharmaceutical compositions and methods and kits for determining one or more biological activities of the library members.

US Patent:

20020197653, Dec 26, 2002

Filed:

Mar 5, 2002

Appl. No.:

10/091240

Inventors:

Matthew Shair - Boston MA, US
Lawrence Chan - Cambridge MA, US

International Classification:

G01N033/567

US Classification:

435/007210

Abstract:

An in vivo assay system for identifying chemical compounds that inhibit or promote a biological event is described. Test compounds may be assayed for their ability to induce the expression of a reporter gene which subsequently leads to the production of a reporter gene product. Preferably the reporter gene product is secreted from the cell or is membrane permeable so that the product is readily detectable. The signal from the reporter gene is preferably amplifiable so that even minute changes in expression of the reporter gene are detectable. The present invention also provided combinatorial libraries for use in the inventive assay system.

US Patent:

20110028478, Feb 3, 2011

Filed:

May 18, 2010

Appl. No.:

12/782650

Inventors:

Mark L. Behnke - Somerville MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Catherine A. Evans - Somerville MA, US
Louis Grenier - Newton MA, US
Michael J. Grogan - Winchester MA, US
Yves Leblanc - Kirkland, CA
Tao Liu - Ashland MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US

Assignee:

Infinity Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/5377
C07D 261/04
A61K 31/42
A61P 29/00
A61P 27/06
A61P 9/10
A61P 37/00
A61P 17/00
A61P 25/28
A61P 1/08
A61P 25/30
A61P 9/12
A61P 3/04
C07D 413/12
A61K 31/4439
A61K 31/506
A61K 31/501
C07D 413/10
A61K 31/4245
A61K 31/4709

US Classification:

5142368, 548240, 514378, 5462721, 514340, 514274, 544318, 544238, 51425205, 548145, 514364, 544298, 514269, 546153, 514312, 544137

Abstract:

The present invention provides isoxazoline FAAH inhibitors of the formula (I):The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.

US Patent:

20110028482, Feb 3, 2011

Filed:

May 18, 2010

Appl. No.:

12/782655

Inventors:

Mark L. Behnke - Somerville MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Catherine A. Evans - Somerville MA, US
Louis Grenier - Newton MA, US
Michael J. Grogan - Winchester MA, US
Yves Leblanc - Kirkland, CA
Tao Liu - Ashland MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US

Assignee:

Infinity Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/498
C07D 413/04
A61K 31/42
C07D 417/14
A61K 31/4439
C07D 401/14
A61K 31/506
A61K 31/427
C07D 401/04
A61K 31/454
C07D 413/06
A61K 31/496
C07D 417/10
A61K 31/428
C07D 403/10
C07D 401/10
A61K 31/4709
A61P 1/00
A61P 3/00
A61P 9/00
A61P 17/00
A61P 25/00
A61P 27/06
A61P 29/00

US Classification:

514249, 548246, 514380, 5462697, 514342, 544298, 514269, 548202, 514365, 546209, 514326, 544367, 51425404, 548163, 514367, 544353, 546167, 514314

Abstract:

The present invention provides isoxazoline FAAH inhibitors of the formula (I):The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.

US Patent:

20110034437, Feb 10, 2011

Filed:

May 18, 2010

Appl. No.:

12/782658

Inventors:

Mark L. Behnke - Somerville MA, US
Alfredo C. Castro - Winchester MA, US
Lawrence K. Chan - Brookline MA, US
Catherine A. Evans - Somerville MA, US
Louis Grenier - Newton MA, US
Michael J. Grogan - Winchester MA, US
Yves Leblanc - Kirkland, CA
Tao Liu - Ashland MA, US
Stephane Peluso - Brookline MA, US
Daniel A. Snyder - Somerville MA, US
Thomas T. Tibbitts - Westford MA, US

Assignee:

Infinity Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31/55
C07D 261/20
A61K 31/42
A61K 31/438
C07D 498/10
A61P 25/00
A61P 3/00
A61P 9/00
A61P 1/08
A61P 25/28
A61P 25/30
A61P 25/20
A61P 3/04

US Classification:

51421202, 548240, 514378, 514278, 546 19, 540543

Abstract:

The present invention provides isoxazoline FAAH inhibitors of the formula (I):The present invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable form thereof, and a pharmaceutically acceptable excipient.The present invention also provides methods for treating an FAAH-mediated condition comprising administering a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable form thereof, to a subject in need thereof.

US Patent:

20130243727, Sep 19, 2013

Filed:

Apr 29, 2013

Appl. No.:

13/872999

Inventors:

Alfredo C. CASTRO - Winchester MA, US
Lawrence K. CHAN - Brookline MA, US
Gregg F. KEANEY - Lexington MA, US
Marta NEVALAINEN - Weymouth MA, US
Vesa NEVALAINEN - Weymouth MA, US
Stephane PELUSO - Brookline MA, US
Thomas T. TIBBITTS - Westford MA, US

Assignee:

INFINITY PHARMACEUTICALS, INC. - Cambridge MA

International Classification:

A61K 31/4192
A61K 31/454
C07D 401/12
C07D 401/06
C07D 249/04
A61K 31/4709
A61K 45/06

US Classification:

424 855, 424 854, 424 857, 514314, 514359, 514326, 514 43

Abstract:

Provided herein are triazole FASN inhibitors of the formula (I):or a pharmaceutically acceptable form thereof; wherein the variables R, X, R, and Rare defined herein.Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

Author:

Lawrence S. Chan

ISBN #:

0849313910