Lawrence H Chan

US Patent:

44779810, Oct 23, 1984

Filed:

Jun 10, 1983

Appl. No.:

6/503387

Inventors:

Lawrence W. Chan - New City NY

International Classification:

F26B 320

US Classification:

34 41

Abstract:

A simulator for simulating on a test sheet the actions of a dryer section of a paper making machine. The simulator includes a closed chamber to which there is connected a temperature and humidity control system to maintain the chamber in constant temperature and humidity during a test. A dryer fabric web is mounted within the chamber and is so guided as to have two parallel runs thereof in closely spaced relation. A holder is provided for mounting a test sheet between the two runs. Dryers are mounted above and below the two runs. The dryer fabric has openings therein which are selectively positioned in centered relation along the two runs so that the upper dryer may pass through an upper opening, pick up a test sheet and press the same against the dryer fabric of the lower run. Then the dryers are moved upwardly, the dryer fabric shifted the align the other opening along the lower run and then the lower dryer may pass through the lower opening and engage the test sheet from the opposite side so as to force the same upwardly against the dryer fabric of the upper run. The dryers may have circumferentially spaced separate heads and the dryers are mounted for timed rotation to present a new head upon each engagement of the test sheet by a respective one of the dryers.

US Patent:

20190275168, Sep 12, 2019

Filed:

May 2, 2016

Appl. No.:

15/569920

Inventors:

- New York NY, US
Yi-Ting TSAI - New York NY, US
Lawrence CHAN - New York NY, US
Stephen H. TSANG - New York NY, US

International Classification:

A61K 48/00
C12N 15/113
A61K 9/00
A61P 27/02

Abstract:

The present disclosure provides methods for treating autosomal dominant diseases in a subject. In some aspects, the methods involve the use of a gene editing enzyme with a pair of unique guide RNA sequences that targets both mutant and wildtype forms of autosomal dominant disease-related gene for destruction in cells, and then supplying the cells with wildtype autosomal dominant disease-related gene cDNA which is codon modified to evade recognition by the guide RNAs. These methods are broadly applicable to any autosomal dominant disease.

US Patent:

20160209441, Jul 21, 2016

Filed:

Apr 22, 2014

Appl. No.:

14/258166

Inventors:

- Cambridge MA, US
Lawrence CHAN - Brooklyn NY, US
William Bell KALB - Cambridge MA, US
Xinyu LIU - Montreal, CA
Brian Anthony MAZZEO - Provo UT, US
George McClelland WHITESIDES - Newton MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

G01P 15/125
G06F 3/044

Abstract:

Accelerometers and capacitive touch sensors fabricated from inexpensive, lightweight, disposable substrate materials, such as paper, are provided. These can be fabricated using simple technologies, such as laser cutting and screen printing. In one embodiment, a touch sensor includes a parallel plate capacitor having a fixed plate formed of a substrate material having a conductive layer and a deflectable plate formed of a paper substrate material having a conductive layer. In a second embodiment, a touch sensor includes a parallel plate capacitor formed of an exterior conductive layer deposited on a paper substrate material and an interior conductive layer deposited on a substrate material. In a third embodiment, a touch sensor includes an active electrode and a grounded electrode patterned on the surface of a paper substrate material. In another embodiment, an accelerometer includes a parallel plate capacitor containing a fixed plate and a free plate containing a paper substrate. Upon an applied acceleration, the distance between the plate of the parallel plate capacitor in an accelerometer changes, eliciting a change in the capacitance of the sensor. Measurement of capacitance can be correlated to the acceleration or deceleration applied to the accelerometer.

Author:

Lawrence S. Chan

ISBN #:

0849313910