Laetitia Devy - Somerville MA, US Henk Pieters - Maastricht, NL Robert C. Ladner - Ijamsville MD, US Rene Hoet - Maastricht, NL Daniel T. Dransfield - Hanson MA, US Clive R. Wood - Boston MA, US Maria Henderikx - Hasselt, BE
Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis.
Evaluating Mmp Expression In Patient Stratification And Other Therapeutic, Diagnostic And Prognostic Methods For Cancer
Clive R. Wood - Boston MA, US Daniel T. Dransfield - Hanson MA, US Laetitia Devy - Somerville MA, US
Assignee:
Dyax Corp. - Burlington MA
International Classification:
C12Q 1/37
US Classification:
435 24
Abstract:
Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e. g. , in patient stratification and evaluation of appropriate therapeutic regimens.
Provided are anti-idiotypic antibodies specific for a CDR of an anti-MMP-14 antibody for use as reagents in novel assays for anti-MMP-14 antibodies, pharmaceutical compositions and vaccines.