Frederick Cohen - San Francisco CA, US Kurt Deshayes - San Francisco CA, US Wayne J. Fairbrother - Burlingame CA, US Bainian Feng - Foster City CA, US John A. Flygare - Burlingame CA, US Lewis J. Gazzard - Belmont CA, US Vickie Hsiao-Wei Tsui - San Francisco CA, US
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I:.
Method Of Inhibiting Insulin-Like Growth Factor-1 (Igf-1) By Igf-1-Antagonist Peptides
Kurt D. Deshayes - San Francisco CA, US Henry B. Lowman - El Granada CA, US Michelle L. Schaffer - Cambridge, GB Sachdev S. Sidhu - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 38/30 C07K 14/65
US Classification:
514 13, 4241301
Abstract:
Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Frederick Cohen - San Francisco CA, US Kurt Deshayes - San Francisco CA, US Wayne J. Fairbrother - Burlingame CA, US Bainian Feng - Foster City CA, US John A. Flygare - Burlingame CA, US Lewis J. Gazzard - Belmont CA, US Vickie Hsiao-Wei Tsui - San Francisco CA, US
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I:.
Jonathan Bayldon Baell - Bundoora, AU Chinh Thien Bui - Balwyn North, AU Peter Colman - East Melbourne, AU Peter Czabotar - Melbourne, AU Danette A. Dudley - Pacifica CA, US Wayne J. Fairbrother - Burlingame CA, US John A. Flygare - Burlingame CA, US Guillaume Laurent Lessene - Coburg, AU Chudi Ndubaku - San Francisco CA, US George Nikolakopoulos - Thomastown, AU Brad Edmund Sleebs - Reservoir, AU Brian John Smith - Sunbury, AU Keith Geoffrey Watson - Surry Hills, AU Steven W. Elmore - Northbrook IL, US Lisa A. Hasvold - Grayslake IL, US Andrew M. Petros - Mundelein IL, US Andrew J. Souers - Evanston IL, US Zhi-Fu Tao - Gurnee IL, US Le Wang - Vernon Hills IL, US Xilu Wang - Grayslake IL, US Kurt Deshayes - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA Abbott Laboratories - Abbott Park IL The Walter and Eliza Hall Institute of Medical Research - Victoria
International Classification:
A61K 31/5377 C07D 413/14
US Classification:
5142338, 544111
Abstract:
In one aspect, the present invention provides for a compound of Formula I.
Kurt Deshayes - San Francisco CA, US Henry Lowman - El Granada CA, US Michelle Schaffer - Cambridge, GB Sachdev Sidhu - San Francisco CA, US
Assignee:
GENENTECH, INC.
International Classification:
A61K038/10 C07K007/08
US Classification:
514/014000, 530/326000
Abstract:
Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Kurt Deshayes - San Francisco CA, US Wayne Fairbrother - Burlingame CA, US John Flygare - Burlingame CA, US Matthew Franklin - San Francisco CA, US Saloumeh Fischer - Casto Valley CA, US Domagoj Vucic - San Francisco CA, US
Assignee:
GENENTECH, INC.
International Classification:
A61K038/08 C07K007/06
US Classification:
514/016000, 530/328000
Abstract:
The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
Kurt Deshayes - San Francisco CA, US Henry Lowman - El Granada CA, US Michelle Schaffer - Cambridge, GB Sachdev Sidhu - San Francisco CA, US
International Classification:
C07K 7/08
US Classification:
530327000, 530328000
Abstract:
Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
Frederick Cohen - San Francisco CA, US Kurt Deshayes - San Francisco CA, US Wayne Fairbrother - Burlingame CA, US Bainian Feng - Foster City CA, US John Flygare - Burlingame CA, US Lewis Gazzard - Belmont CA, US Vickie Tsui - San Francisco CA, US
The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R, R, R, R, R′, R, R′, Rand R′ are as described herein.
Kurt Deshayes
Private Consultant
Chemical Biology Consultants
Private Consultant
Education:
University of Chicago 1983 - 1988
Doctorates, Doctor of Philosophy, Organic Chemistry
Carleton College 1979 - 1983
Bachelors, Bachelor of Arts, Chemistry
Skills:
Drug Design Cell Biology Chemistry Organic Synthesis Biotechnology Cell Pcr Cell Culture Drug Discovery Molecular Biology Lifesciences Oncology Drug Development Mass Spectrometry Cancer Medicinal Chemistry Protein Expression Protein Purification Biochemistry Pharmaceutical Industry Technology Transfer Protein Chemistry