Kumar G Gadamasetti

Author:

Kumar G. Gadamasetti

ISBN #:

0585157235

Author:

Kumar G. Gadamasetti

ISBN #:

0824719816

Author:

Kumar Gadamasetti

ISBN #:

0849390516

US Patent:

6515136, Feb 4, 2003

Filed:

Aug 27, 1998

Appl. No.:

09/141402

Inventors:

Richard P. Polniaszek - Dayton NJ
Xuebao Wang - East Brunswick NJ
Jeffrey S. DePue - Somerville NJ
Chennagiri R. Pandit - Somerset NJ
Kumar G. Gadamasetti - Princeton Junction NJ
Yadagiri Pendri - Matawan NJ
Eduardo J. Martinez - Plainsboro NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D41312

US Classification:

548235

Abstract:

Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.

US Patent:

20070238742, Oct 11, 2007

Filed:

Apr 13, 2007

Appl. No.:

11/734831

Inventors:

Aleem Gangjee - Allison Park PA, US
George Martin - Rockville MD, US
Kumar Gadamasetti - Belmont CA, US

International Classification:

A61K 31/519
C07D 491/02

US Classification:

514260100, 544278000

Abstract:

Stereoselective methods for preparing the individual isomers, E- and Z-2,4-substituted-5-vinylfuro[2,3-d]pyrimidine and pharmaceutically acceptable salts, solvates, and prodrugs thereof using selective synthetic conditions are provided. This class of pyrimidine compounds function as receptor tyrosine kinase inhibitors during angiogenesis and resists the development of new blood vessels in tumors as well as inhibit the folate pathway required for cell growth. The isomers of these compounds are separated by physical, chromatographic, and/or HPLC methods. Their biological activities are described. Also provided are methods of treating diseases associated with angiogenesis in a patient comprising administering the isolated E- and Z-isomers of the composition of the present invention.

US Patent:

58565078, Jan 5, 1999

Filed:

Jan 21, 1997

Appl. No.:

8/786523

Inventors:

Richard P. Polniaszek - Dayton NJ
Xuebao Wang - East Brunswick NJ
Jeffrey S. DePue - Somerville NJ
Chennagiri R. Pandit - Somerset NJ
Kumar G. Gadamasetti - Princeton Junction NJ
Yadagiri Pendri - Matawan NJ
Eduardo J. Martinez - Plainsboro NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D41312

US Classification:

548241

Abstract:

Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.