Kshitij A Patkar

US Patent:

20090111741, Apr 30, 2009

Filed:

Oct 9, 2008

Appl. No.:

12/248252

Inventors:

Jane V. Aldrich - Lawrence KS, US
Kshitij A. Patkar - Lawrence KS, US
Jay McLaughlin - Natick MA, US

International Classification:

A61K 38/00
A61K 38/12
C12N 5/00
A61P 25/00

US Classification:

514 9, 514 12, 435375

Abstract:

A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related substance. The dynorphin-A analog can be a cyclic dynorphin-A analog having sufficient systemic stability that crosses the blood-brain barrier so as to be active in the brain at kappa-opioid receptors (KOR) as an antagonist. Such activity at a KOR as an antagonist can be useful for cocaine management and reducing the desire, such as stress-related desires, for use of cocaine, crack, or the like. The KOR antagonist can be [N-benzylTyr,cyclo(D-Asp,Dap)]Dyn A-(1-11) amide, salt thereof, prodrug thereof, and/or derivative thereof.