Kristine M Mckinney

US Patent:

20210128721, May 6, 2021

Filed:

Nov 18, 2020

Appl. No.:

16/951092

Inventors:

- Cambridge MA, US
Jared IACOVELLI - Waltham MA, US
Kristine MCKINNEY - Cambridge MA, US
Nicholas VALIANTE - Cambridge MA, US

International Classification:

A61K 39/39
A61K 39/00
A61K 9/00
A61K 9/51
A61P 35/00
A61K 9/50
C07K 14/725

Abstract:

The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

US Patent:

20200261572, Aug 20, 2020

Filed:

Nov 1, 2019

Appl. No.:

16/671921

Inventors:

- Cambridge MA, US
Jared IACOVELLI - Waltham MA, US
Kristine MCKINNEY - Cambridge MA, US
Kristen HOPSON - Arlington MA, US

International Classification:

A61K 39/39
A61K 31/7088
A61P 35/00
A61K 39/00
A61K 39/02
C12N 7/00
A61K 39/12
C07K 14/47
A61K 9/51

Abstract:

The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.

US Patent:

20190351039, Nov 21, 2019

Filed:

Feb 1, 2018

Appl. No.:

16/482473

Inventors:

- Cambridge MA, US
Jared IACOVELLI - Waltham MA, US
Kristine MCKINNEY - Cambridge MA, US
Nicholas VALIANTE - Cambridge MA, US

International Classification:

A61K 39/00
A61K 9/50
A61K 39/39
A61K 9/51
A61K 9/00

Abstract:

The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

US Patent:

20190175727, Jun 13, 2019

Filed:

Feb 19, 2019

Appl. No.:

16/279372

Inventors:

- Cambridge MA, US
Jared IACOVELLI - Waltham MA, US
Kristine MCKINNEY - Cambridge MA, US
Nicholas VALIANTE - Cambridge MA, US

International Classification:

A61K 39/39
C07K 14/725
A61K 9/50
A61P 35/00

Abstract:

The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.

US Patent:

20180311343, Nov 1, 2018

Filed:

Jun 1, 2018

Appl. No.:

15/995519

Inventors:

- Cambridge MA, US
Jared IACOVELLI - Waltham MA, US
Kristine MCKINNEY - Cambridge MA, US
Kristen HOPSON - Arlington MA, US

International Classification:

A61K 39/39
A61P 35/00
A61K 39/00
A61K 9/51
C07K 14/47
A61K 39/12
C12N 7/00
A61K 39/02

Abstract:

The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.

US Patent:

20170210788, Jul 27, 2017

Filed:

Jul 23, 2015

Appl. No.:

15/328187

Inventors:

- Cambridge MA, US
Josh FREDERICK - Charlestown MA, US
Kristine MCKINNEY - Cambridge MA, US
Christina HENDERSON - Stow MA, US

International Classification:

C07K 16/18
A61K 48/00
C07K 14/79
A61K 9/16
C07K 14/78
C07K 14/81

Abstract:

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modified polynucleotides comprising at least one intrabody construct.