Konrad T Howitz

US Patent:

20050136537, Jun 23, 2005

Filed:

Jul 2, 2004

Appl. No.:

10/884879

Inventors:

David Sinclair - West Roxbury MA, US
Konrad Howitz - Allentown PA, US
Robert Zipkin - Wynnewood PA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
BIOMOL International L.P. - Plymouth Meeting PA

International Classification:

C12N005/02

US Classification:

435375000, 424766000

Abstract:

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

US Patent:

20060014705, Jan 19, 2006

Filed:

Jun 24, 2005

Appl. No.:

11/166892

Inventors:

Konrad Howitz - Allentown PA, US
Robert Zipkin - Wynnewood PA, US

International Classification:

A61K 31/7048
A61K 31/519
A61K 31/353
A61K 31/35
A61K 31/655
A61K 31/05

US Classification:

514027000, 514262100, 514456000, 514151000, 514733000

Abstract:

Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.

US Patent:

20060025337, Feb 2, 2006

Filed:

Mar 7, 2005

Appl. No.:

11/074374

Inventors:

David Sinclair - West Roxbury MA, US
Minh Nguyen - Boston MA, US
Konrad Howitz - Allentown PA, US
Robert Zipkin - Wynnewood PA, US
Kevin Bitterman - Boston MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 38/17
A61K 48/00
C12Q 1/02

US Classification:

514012000, 435029000, 514044000

Abstract:

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine. Also disclosed herein are methods for treating, preventing or diagnosing a disease associated with neuronal cell death, e.g., a neurodegenerative disease.

US Patent:

20060084135, Apr 20, 2006

Filed:

Jul 1, 2004

Appl. No.:

10/884062

Inventors:

Konrad Howitz - Allentown PA, US
Robert Zipkin - Wynnewood PA, US

International Classification:

C12Q 1/02

US Classification:

435029000

Abstract:

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

US Patent:

20100035885, Feb 11, 2010

Filed:

Jun 8, 2009

Appl. No.:

12/479883

Inventors:

David A. Sinclair - Chestnut Hill MA, US
Konrad T. Howitz - Allentown PA, US
Robert E. Zipkin - Wynnewood PA, US
Kevin J. Bitterman - Boston MA, US
Dudley W. Lamming - Boston MA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA
BIOMOL International L.P. - Plymouth Meeting PA

International Classification:

A61K 31/4985
C12N 5/02
C12N 5/071
C12N 5/07
A61K 31/17

US Classification:

514249, 435375, 435366, 435363, 435349, 435350, 435351, 435352, 514597

Abstract:

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.

US Patent:

20120172340, Jul 5, 2012

Filed:

Oct 7, 2010

Appl. No.:

12/900073

Inventors:

Konrad T. Howitz - Allentown PA, US
Robert E. Zipkin - Wynnewood PA, US

Assignee:

BIOMOL International L.P. - Plymouth Meeting PA

International Classification:

A61K 31/655
C12N 9/99
C12N 9/78
A61K 31/519
A61K 31/435
A61K 31/35
A61K 31/235
A61K 31/185
A61K 31/16
A61K 31/12
A61K 31/05
A61K 31/04
A61P 3/10
A61P 3/06
C12Q 1/34

US Classification:

514151, 435 18, 435184, 435227, 5142621, 514277, 514456, 514544, 514576, 514616, 514630, 514689, 514733, 514740

Abstract:

Methods for identifying selective activators of SIRT5 and/or SIRT1 and methods for using these selective activators in the modulation of SIRT5 and/or SIRT1 are provided.

US Patent:

20120183948, Jul 19, 2012

Filed:

Jan 13, 2011

Appl. No.:

12/930693

Inventors:

Konrad T. Howitz - Allentown PA, US
Zhongda Zhang - Wynnewood PA, US
Anne Kisielewski - Wilmington DE, US
Elizabeth Dale - Allentown PA, US
Wayne Forrest Patton - Dix Hills NY, US

Assignee:

ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. - NEW YORK NY

International Classification:

C12Q 1/00
C07D 493/10
C07D 311/16

US Classification:

435 4, 549288, 549265

Abstract:

Provided is a compound that comprises the structure: