Matti Gerund Kiupel

US Patent:

20040038202, Feb 26, 2004

Filed:

Jan 30, 2003

Appl. No.:

10/354606

Inventors:

Roger Maes - Okemos MI, US
Annabel Wise - Bath MI, US
Matti Kiupel - Laingsburg MI, US

Assignee:

Michigan State University - East Lansing MI

International Classification:

C12Q001/70
C07H021/04
C12N007/00
C07K014/165

US Classification:

435/005000, 435/069100, 435/320100, 435/325000, 435/235100, 530/388300, 530/350000, 536/023720

Abstract:

The present invention relates to the use of novel nucleotide sequences for the spike peptide, pol region peptide and M and N region peptide of the ferret coronavirus and derivative products for the diagnosis and treatment of epizootic catarrhal enteritis (ECE) in ferrets.

US Patent:

20040071728, Apr 15, 2004

Filed:

Aug 22, 2003

Appl. No.:

10/311423

Inventors:

Suresh Mittal - West Lafayette IN, US
Gregory Stevenson - West Lafayette IN, US
Jiwon Choi - West Lafayette IN, US
Matti Kiupel - Lansing MI, US
Charles Kanitz - Lafayette IN, US

International Classification:

C12Q001/70
C07H021/04
A61K039/12
C12N007/00
C07K014/005

US Classification:

424/186100, 435/005000, 435/069100, 435/320100, 435/235100, 435/325000, 536/023720, 530/350000

Abstract:

The invention is based on the cloning of porcine circovirus (PCV) strains from pigs with congenital tremors. These results provide a first step for the development of diagnostic and therapeutic diagnostic method comprises determining whether the pig has been infected by a porcine cirovirus strain of type 1 or type 2. The invention further provides a method for the prevention or treatment of congenital tremors in a pig, which method comprises administering to the pig an effective amount of an immunogenic PCV 1 or PCV 2 polypeptide or of a nucleic acid encoding this polypeptide. Another subject of the invention is the new PCV nucleic acid sequences identified by the inventors and the polypeptides encoded by these sequences, as well as the new PCV isolates and immunogenic preparations thereof.