Kerrie L Faia from 10 Honor Pl, Topsfield, MA 01983, age 51, Phone: 617 304-6484

Methods And Compositions For Identification, Assessment And Treatment Of Cancers Associated With Hedgehog Signaling
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US Patent:

20120010230, Jan 12, 2012
Filed:

Jul 8, 2011
Appl. No.:

13/179438
Inventors:

John R. MacDougall - Hingham MA, US
Juan Guillermo Paez - Spencer MA, US
Karen J. McGovern - Groton MA, US
Jeffery L. Kutok - Natick MA, US
Georgios Skliris - Cambridge MA, US
Kerry White - Medford MA, US
Kerrie L. Faia - Topsfield MA, US
Marisa Osswalt Peluso - Brookline MA, US
Veronica Travaglione Campbell - Framingham MA, US
International Classification:

A61K 31/4355
A61P 35/02
G01N 33/53
C12Q 1/02
C12Q 1/68
C12Q 1/37
C12Q 1/48
A61P 35/00
C40B 30/04
US Classification:

514278, 435 71, 506 9, 435 612, 435 23, 435 15, 435 29
Abstract:

Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.

Methods For Analysis Of Hedgehog Pathway Inhibitors
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US Patent:

20100099116, Apr 22, 2010
Filed:

Jan 14, 2008
Appl. No.:

12/521079
Inventors:

Kerrie L. Faia - Topsfield MA, US
Everton Mandley - Dorchester MA, US
Wei Niu - Wayland MA, US
Christine Pien - Topsfield MA, US
Assignee:

Infinity Discovery, Inc. - Cambridge MA
International Classification:

G01N 33/53
G01N 33/68
C12Q 1/48
US Classification:

435 71, 436 86, 435 15
Abstract:

One aspect of the present invention relates to a method of ascertaining the inhibitory activity in a mammal of a candidate inhibitor of the hedgehog pathway. In certain embodiments, the candidate inhibitor is administered systemically. In certain embodiments, the mammal is a rodent or primate. In certain embodiments, the mammal is a mouse. In certain embodiments, the candidate inhibitor is a small molecule or natural product.

Methods And Compositions For Identification, Assessment And Treatment Of Cancers Associated With Hedgehog Signaling
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US Patent:

20150025012, Jan 22, 2015
Filed:

Aug 8, 2014
Appl. No.:

14/455760
Inventors:

- Cambridge MA, US
Juan Guillermo Paez - Spencer MA, US
Karen J. McGovern - Groton MA, US
Jeffery L. Kutok - Natick MA, US
Georgios Skliris - Cambridge MA, US
Kerry White - Medford MA, US
Kerrie L. Faia - Topsfield MA, US
Marisa Osswalt Peluso - Brookline MA, US
Veronica Travaglione Campbell - Framingham MA, US
International Classification:

G01N 33/574
A61K 31/7068
A61N 5/10
G01N 33/50
C12Q 1/68
A61K 31/4355
A61K 38/38
US Classification:

514 152, 514278, 514 49, 435 15, 435 612, 506 9, 435 792, 600 1
Abstract:

Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.

Kerrie L Faia