Kazuki Sugahara

US Patent:

20090226372, Sep 10, 2009

Filed:

Feb 20, 2009

Appl. No.:

12/390061

Inventors:

Erkki Ruoslahti - Buellton CA, US
Tambet Teesalu - Goleta CA, US
Kazuki Sugahara - Goleta CA, US

Assignee:

Burnham Institute for Medical Research - La Jolla CA

International Classification:

A61K 49/00
C07K 14/00
C12Q 1/04
A61P 35/00

US Classification:

424 91, 530402, 435 34

Abstract:

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

US Patent:

20090246133, Oct 1, 2009

Filed:

Jan 16, 2009

Appl. No.:

12/355672

Inventors:

Erkki Ruoslahti - Buellton CA, US
Tambet Teesalu - Goleta CA, US
Kazuki Sugahara - Goleta CA, US

Assignee:

Burnham Institute for Medical Research - La Jolla CA

International Classification:

A61K 47/42
C07K 7/00
C07K 7/64
A61K 51/08
A61P 35/00
A61P 27/00
A61P 17/00

US Classification:

424 169, 530328, 514773, 514 44 R, 514 8

Abstract:

Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing αv integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing αv integrins.

US Patent:

20100322862, Dec 23, 2010

Filed:

Jun 22, 2010

Appl. No.:

12/821050

Inventors:

Erkki Ruoslahti - Buellton CA, US
Tambet Teesalu - Goleta CA, US
Kazuki Sugahara - Goleta CA, US

Assignee:

Burnham Institute for Medical Research - La Jolla CA

International Classification:

A61K 49/00
A61K 39/395
A61K 31/7088
A61K 35/76
A61K 47/42
C12N 5/07
A61K 9/127
A61K 31/704
A61P 35/00
A61K 38/18
A61K 35/00
A61P 29/00
A61P 19/02

US Classification:

424 91, 4241301, 514 44 R, 424 936, 514773, 435325, 424450, 514 34, 4241331, 514 76, 424 931

Abstract:

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

US Patent:

20110262347, Oct 27, 2011

Filed:

Apr 8, 2011

Appl. No.:

13/083176

Inventors:

Erkki Ruoslahti - Buellton CA, US
Lilach Agemy - Santa Barbara CA, US
Venkata Ramana Kotamraju - Goleta CA, US
Kazuki Sugahara - Goleta CA, US
Inder Verma - La Jolla CA, US

International Classification:

A61K 51/00
C07K 7/08
C07K 14/76
A61K 47/42
A61K 9/127
C07F 13/00
C07H 21/00
A61K 38/16
A61K 31/7088
A61K 31/28
C07D 305/14
A61K 31/337
A61K 49/00
A61P 35/00
A61P 43/00
C07K 7/06
B82Y 5/00

US Classification:

424 111, 530330, 530329, 530327, 530326, 530362, 514773, 424450, 534 14, 536 231, 514 193, 514 44 R, 514492, 549510, 514449, 424 91, 977700, 977811, 977838

Abstract:

Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

US Patent:

20130343989, Dec 26, 2013

Filed:

Jan 30, 2013

Appl. No.:

13/754105

Inventors:

Kazuki Sugahara - Goleta CA, US
Tambet Teesalu - Goleta CA, US

Assignee:

Sanford-Burnham Medical Research Institute - La Jolla CA

International Classification:

C07K 7/06
A61K 51/08
C07K 7/64

US Classification:

424 169, 530317, 530328, 4352351, 514 133, 424 91, 424 936

Abstract:

Disclosed are compositions and methods useful for targeting tissue undergoing angiogenesis or to cells or tissue expressing αv integrins. The compositions and methods are based on peptide sequences that selectively bind to and home to tissue undergoing angiogenesis or to cells or tissue expressing αv integrins in animals. The disclosed targeting is useful for delivering therapeutic and detectable agents to tissue experiencing angiogenesis or to cells or tissue expressing αv integrins.

US Patent:

20220175941, Jun 9, 2022

Filed:

Jul 12, 2021

Appl. No.:

17/373496

Inventors:

- La Jolla CA, US
Tambet Teesalu - La Jolla CA, US
Kazuki Sugahara - La Jolla CA, US

International Classification:

A61K 47/66
B82Y 5/00

Abstract:

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

US Patent:

20200156935, May 21, 2020

Filed:

Jul 29, 2019

Appl. No.:

16/524869

Inventors:

- La Jolla CA, US
Tambet Teesalu - La Jolla CA, US
Kazuki Sugahara - La Jolla CA, US

International Classification:

B82Y 5/00
A61K 47/66

Abstract:

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

US Patent:

20180244720, Aug 30, 2018

Filed:

Apr 22, 2016

Appl. No.:

15/568533

Inventors:

- La Jolla CA, US
Erkki Ruoslahti - La Jolla CA, US
Kazuki Sugahara - La Jolla CA, US
Shweta Sharma - La Jolla CA, US

Assignee:

Sanford Burnham Prebys Medical Discovery Institute - La Jolla CA

International Classification:

C07K 7/06
A61K 47/64
G01N 33/68

Abstract:

Disclosed are peptides and peptidomimetics that in some embodiments include the amino acid sequence KRGARST or (SEQ ID NO: 1), AKRGARSTA or (SEQ ID NO: 2), or CKRGARSTC (SEQ ID NO: 3). Also disclosed are conjugates and compositions that onclude the peptides and/or peptidomimetics, methods for directing a moiety to tumor lymphatic vasculature, methods for imaging tumor lymphatic vasculature, methods for reducing or inhibiting tumor metastasis, methods for reducing the number of tumor lymphatic vessels, methods for treating cancer, methods for treating a disease or disorder associated with a gC1q/p32 receptor biological activity, methods for detecting the presence of a gC1q/p32 receptor, methods for detecting interactions between gC1q/p32 receptors and the presently disclosed conjugates and compositions, methods for delivering the presently disclosed conjugates and compositions to gC1q/p32 receptors, methods for assessing gC1q/p32 receptor levels in cells, methods for identifying subjects having diseases associated with gC1q/p32 receptor biological activities, and methods for screening for compounds that interact with gC1q/p32 receptors.