Katherine W Jones

US Patent:

8372819, Feb 12, 2013

Filed:

Apr 1, 2011

Appl. No.:

13/078813

Inventors:

Katherine Jones - Solana Beach CA, US
Lirong Zhang - San Diego CA, US
Vanessa Bres - San Diego CA, US
Yupeng Chen - San Diego CA, US

Assignee:

Salk Institute for Biological Studies - La Jolla CA

International Classification:

A61K 48/00

US Classification:

514 44, 536 245, 536 2431, 536 241

Abstract:

Provided herein are methods and compositions for modulating apoptosis by targeting SKIP (Ski-interacting protein) activity. Methods of increasing DNA damage-induced cell death in cancer cells, and reducing DNA damage-induced cell death in normal cells are provided.

US Patent:

62709569, Aug 7, 2001

Filed:

Jul 30, 1998

Appl. No.:

9/126980

Inventors:

Katherine A. Jones - Encinitas CA
Ping Wei - Brookeville MD
Mitchell Garber - Woodland Hills CA
Shi-Min Fang - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 170
A61K 3800
C07K 100
C07K 1600

US Classification:

435 5

Abstract:

In accordance with the present invention, a host cell protein has been discovered which regulates Tat transactivation. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.

US Patent:

62844563, Sep 4, 2001

Filed:

Dec 30, 1999

Appl. No.:

9/476482

Inventors:

Katherine A. Jones - Encinitas CA
Ping Wei - San Diego CA
Mitchell Garber - Woodland Hills CA
Shi-Min Fang - San Diego CA

Assignee:

The Salk Institute for Biological Studies - La Jolla CA

International Classification:

C12Q 170
A61K 3800
C07K 100
C07K 1600
C07H 2102

US Classification:

435 5

Abstract:

In accordance with the present invention, isolated nucleic acid encoding a host cell protein that regulates Tat transactivation has been discovered. The protein is the first discovered constituent of the TAK/TEFb complex which associates with the HIV Tat, via divalent cation metals, and is necessary for the binding of Tat to TAR RNA. This protein, cyclin T1, is an 87 kDa cyclin partner for the PITALRE kinase. It is further discovered that Tat must interact with TAK in order to bind to TAR RNA with affinity and with the appropriate sequence specificity that is observed in vivo. In accordance with another aspect of the invention, formulations useful for modulation of Tat transactivation have been developed. In addition, assays have been developed for the identification of compounds useful to modulate the above-described processes.

Author:

Katherine Burton Jones

ISBN #:

0824725816

Author:

Katherine D. Jones

ISBN #:

0758212933

Author:

Katherine D. Jones

ISBN #:

0758212941

Author:

Katherine Jones

ISBN #:

0394700147