Karina R Romero

US Patent:

7776857, Aug 17, 2010

Filed:

Apr 3, 2008

Appl. No.:

12/080669

Inventors:

Victor Cee - Thousand Oaks CA, US
Holly Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Zihao Hua - Tewksbury MA, US
Matthew Martin - Cambridge MA, US
Isaac Marx - Somerville MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip Olivieri - Charlestown MA, US
Kathleen Panter - Cambridge MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 237/30

US Classification:

514248, 544237, 546123

Abstract:

The present invention relates to chemical compounds having a general formula I.

US Patent:

7776869, Aug 17, 2010

Filed:

Oct 14, 2005

Appl. No.:

11/251490

Inventors:

Stuart C. Chaffee - Cambridge MA, US
Brian K. Albrecht - Cambridge MA, US
Brian L. Hodous - Cambridge MA, US
Matthew W. Martin - Arlington MA, US
David C. McGowan - Woluwe Street Pierre, BE
Erin F. DiMauro - Cambridge MA, US
Gade Reddy - Newbury Park CA, US
Victor J. Cee - Mansfield MA, US
Philip R. Olivieri - Medford MA, US
Anthony Reed - Oxnard CA, US
Karina Romero - Cambridge MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 239/38
C07D 239/42
A61K 31/505
A61K 31/506
A61P 35/00

US Classification:

514269, 514275, 544299, 544309, 544317, 544320, 544321, 544323, 544324

Abstract:

The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I.

US Patent:

7868177, Jan 11, 2011

Filed:

Feb 21, 2007

Appl. No.:

11/709994

Inventors:

Victor J. Cee - Thousand Oaks CA, US
Holly L. Deak - Brookline MA, US
Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip R. Olivieri - Medford MA, US
Vinod F. Patel - Acton MA, US
Karina Romero - Cambridge MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 403/14
A61K 31/4427
A61K 31/506
A61K 31/53
A61P 19/02
A61P 35/00

US Classification:

5462681, 546288, 514341, 514345, 514269, 514275, 514241, 544242, 544180

Abstract:

The present invention relates to chemical compounds having a general formula I.

US Patent:

7880000, Feb 1, 2011

Filed:

May 9, 2005

Appl. No.:

11/126000

Inventors:

Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Stuart C. Chaffee - Cambridge MA, US
Paul A. Tempest - Brookline MA, US
Philip R. Olivieri - Medford MA, US
Rebecca E. Johnson - Arlington VA, US
Brian K. Albrecht - Cambridge MA, US
Vinod F. Patel - Acton MA, US
Victor J. Cee - Mansfield MA, US
Joseph L. Kim - Wayland MA, US
Steven Bellon - Wellesley MA, US
Xiaotian Zhu - Newton MA, US
Yuan Cheng - Newbury Park CA, US
Ning Xi - Thousand Oaks CA, US
Karina Romero - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Holly L. Deak - Brookline MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 403/14
A61K 31/53
A61K 31/4427
A61K 31/506
A61P 19/02
A61P 35/00

US Classification:

544320, 544322, 544182, 514272, 514274, 514242

Abstract:

The present invention relates to chemical compounds having a general formula I.

US Patent:

7981891, Jul 19, 2011

Filed:

Jun 30, 2010

Appl. No.:

12/828067

Inventors:

Holly Deak - Brookline MA, US
Stephanie Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Zihao Hua - Tewksbury CA, US
Mathew Martin - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip Olivieri - Charlestown MA, US
Kate Panter - Cambridge MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US
Ryan White - Somerville MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/502

US Classification:

514248, 514311, 544237, 546152

Abstract:

The present invention relates to chemical compounds having a general formula I.

US Patent:

8022221, Sep 20, 2011

Filed:

Feb 12, 2009

Appl. No.:

12/378426

Inventors:

Victor J. Cee - Thousand Oaks CA, US
Holly L. Deak - Brookline MA, US
Bingfan Du - Cambridge MA, US
Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Philip R. Olivieri - Medford MA, US
Vinod F. Patel - Acton MA, US
Karina Romero - Cambridge MA, US
Laurie Schenkel - Boston MA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 403/14
A61K 31/53
A61K 31/4427
A61K 31/506
A61P 19/02
A61P 35/00

US Classification:

5462681, 546288, 514345, 514341, 514242, 514272, 514274, 514241, 514245, 51425201, 51425202, 5142521, 514256, 514269, 514275, 514277, 514336, 514340, 514348, 544182, 544320, 544322, 544408, 544180, 544209, 544219, 544238, 544239, 544240, 544295, 544297, 544310, 544317, 544324, 544328, 544331, 544405

Abstract:

The present invention relates to chemical compounds having a general formula I.

US Patent:

8198448, Jun 12, 2012

Filed:

Oct 14, 2008

Appl. No.:

12/287791

Inventors:

Brian K. Albrecht - Cambridge MA, US
David Bauer - Sudbury MA, US
Alessandro Boezio - Somerville MA, US
Deborah Choquette - Medford MA, US
Jean-Christophe Harmange - Andover MA, US
Richard T. Lewis - Framingham MA, US
Julia Lohman - Cambridge MA, US
Michelle Potashman - Cambridge MA, US
Emily A. Peterson - Cambridge CA, US
Katrina W. Copeland - San Gabriel CA, US
Karina Romero - Cambridge MA, US

Assignee:

Amgen Inc. - South San Francisco CA

International Classification:

C07D 487/04
C07D 403/12
C07D 403/14
A61K 31/53
A61P 35/00

US Classification:

546119, 546121, 514300, 514303

Abstract:

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

8476434, Jul 2, 2013

Filed:

Nov 22, 2010

Appl. No.:

12/952156

Inventors:

Stephanie D. Geuns-Meyer - Medford MA, US
Brian L. Hodous - Cambridge MA, US
Stuart C. Chaffee - Boston MA, US
Paul Tempest - Boston MA, US
Ning Xi - Thousand Oaks CA, US
Phillip R. Olivieri - Charlestown MA, US
Joseph L. Kim - Wayland MA, US
Steven Bellon - Wellesley MA, US
Xiaotian Zhu - Newton MA, US
Yuan Cheng - Newbury Park CA, US
Brian K. Albrecht - Cambridge MA, US
Vinod F. Patel - Acton MA, US
Victor J. Cee - Thousand Oaks CA, US
Karina Romero - Cambridge MA, US
Hanh Nho Nguyen - Arlington MA, US
Holly L. Deak - Brookline MA, US
Rebecca E. Johnson - Arlington VA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

C07D 401/12
C07D 401/14
C07D 403/12
C07D 403/14
A61K 31/4427
A61K 31/506
A61K 31/54
A61P 19/02
A61P 35/00

US Classification:

544320, 544322, 544180, 514272, 514275, 514241

Abstract:

The present invention relates to chemical compounds having a general formula I.