Karen Rosen Wallace

US Patent:

20070087000, Apr 19, 2007

Filed:

Aug 14, 2006

Appl. No.:

11/503062

Inventors:

Frank Walsh - Bryn Mawr PA, US
Margaret Zaleska - Narberth PA, US
David Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas Pangalos - Pennington NJ, US
William Kelley - Reading MA, US

International Classification:

A61K 39/395
C07K 16/22

US Classification:

424145100, 530388250

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

20120003212, Jan 5, 2012

Filed:

Feb 18, 2011

Appl. No.:

13/030978

Inventors:

FRANK S. WALSH - BRYN MAWR PA, US
MARGARET M. ZALESKA - NARBERTH PA, US
DAVID S. HOWLAND - YARDLEY PA, US
LIOUDMILA TCHISTIAKOVA - ANDOVER MA, US
RIYEZ KARIM - NORTH ANDOVER MA, US
PAMELA KELLEY - READING MA, US
XIANG-YANG TAN - READING MA, US
SEUNG POON KWAK - EWING NJ, US
KAREN WALLACE - NEWTOWN SQUARE PA, US
NICHOLAS WEBER - MOUNTAINTOP PA, US
MENELAS N. PANGALOS - PENNINGTON NJ, US
WILLIAM KELLEY - READING MA, US

Assignee:

THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - PHILADELPHIA PA
WYETH LLC - MADISON NJ

International Classification:

A61K 39/395
A61P 21/00

US Classification:

4241331, 4241581

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

US Patent:

20120016106, Jan 19, 2012

Filed:

Mar 2, 2011

Appl. No.:

13/038954

Inventors:

Frank S. Walsh - Bryn Mawr PA, US
Margaret M. Zaleska - Narberth PA, US
David S. Howland - Yardley PA, US
Lioudmila Tchistiakova - Andover MA, US
Riyez Karim - North Andover MA, US
Pamela Kelley - Reading MA, US
William Kelley - Reading MA, US
Xiang-Yang Tan - Reading MA, US
Seung Poon Kwak - Ewing NJ, US
Karen Wallace - Newtown Square PA, US
Nicholas Weber - Philadelphia PA, US
Menelas N. Pangalos - Pennington NJ, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07K 16/00
C12N 5/10
C07H 21/04
C12N 1/19
C12N 15/63
C12P 21/06
C12N 1/21

US Classification:

5303871, 435 696, 435325, 435352, 435358, 435365, 435367, 4352523, 43525231, 43525233, 4352542, 43525421, 43525422, 4353201, 536 2353

Abstract:

The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.