Kan Y Lam

US Patent:

7078060, Jul 18, 2006

Filed:

Feb 12, 2003

Appl. No.:

10/364983

Inventors:

Robert E. Burrell - Alberta, CA
John B. Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US
Hua Qing Yin - Alberta, CA
Antony G. Naylor - Alberta, CA
Peter H. Moxham - Alberta, CA
Scott H. Gillis - Concord MA, US
Paul Schechter - Dover MA, US

Assignee:

Nucryst Pharmaceuticals Corp. - Fort Saskatchewan

International Classification:

A61K 33/38
A61K 31/28
A61K 9/127
A61K 9/133
A61K 9/52
A61P 17/00
A61P 17/02

US Classification:

424618, 424450, 424489, 424619, 514184, 514275, 514498, 514772, 514858, 514859, 514865, 514886, 514887, 514936, 514937, 514938, 514946, 514964

Abstract:

Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

US Patent:

7470437, Dec 30, 2008

Filed:

Nov 10, 2004

Appl. No.:

10/985204

Inventors:

Robert E. Burrell - Sherwood Park, CA
John B. Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US
Antony G. Naylor - Cambridge, CA
Peter H. Moxham - Sherwood Park, CA
Scott H. Gillis - Concord MA, US
Paul Schechter - Dover MA, US

Assignee:

Nucryst Pharmaceuticals Corp. - Fort Saskatchewan, Alberta

International Classification:

A61K 9/14
A61K 31/28
A61K 33/24
A61K 33/38
A61P 1/00

US Classification:

424618, 424489, 424619, 514495, 514901, 514951

Abstract:

Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

US Patent:

20030021854, Jan 30, 2003

Filed:

Apr 23, 2002

Appl. No.:

10/131568

Inventors:

Robert Burrell - Sherwood Park, CA
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US

International Classification:

A61K033/38
A61K033/24

US Classification:

424/618000, 424/649000

Abstract:

The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial metals, a nanocrystalline powder of one or more antimicrobial metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial metals.

US Patent:

20030072810, Apr 17, 2003

Filed:

May 30, 2002

Appl. No.:

10/159587

Inventors:

Robert Burrell - Sherwood Park, CA
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US

International Classification:

A61K033/38
A61K033/24

US Classification:

424/618000, 424/649000

Abstract:

The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a disease condition in a human or an animal by contacting the cell with a therapeutically effective amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases, wherein the one or more noble metals is formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial or noble metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.

US Patent:

20030170314, Sep 11, 2003

Filed:

Oct 22, 2002

Appl. No.:

10/277356

Inventors:

Robert Burrell - Alberta, CA
Scott Gillis - Concord MA, US
Paul Schechter - Dover MA, US
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US
Hua Yin - Alberta, CA
Antony Naylor - Alberta, CA
Peter Moxham - Alberta, CA

International Classification:

A61K033/38
A61K033/26
A61K033/24

US Classification:

424/618000, 424/646000, 424/649000

Abstract:

Compositions of metal-containing compounds are disclosed. Methods of preparing and using the compositions, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

US Patent:

20030180379, Sep 25, 2003

Filed:

Oct 22, 2002

Appl. No.:

10/277673

Inventors:

Robert Burrell - Alberta, CA
Scott Gillis - Concord MA, US
Paul Schechter - Dover MA, US
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US
Hua Yin - Alberta, CA
Antony Naylor - Alberta, CA
Peter Moxham - Alberta, CA

International Classification:

A61K033/38
A61K033/26
A61K033/24

US Classification:

424/618000, 424/646000, 424/649000

Abstract:

Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

US Patent:

20030185901, Oct 2, 2003

Filed:

Oct 22, 2002

Appl. No.:

10/277358

Inventors:

Robert Burrell - Alberta, CA
Scott Gillis - Concord MA, US
Paul Schechter - Dover MA, US
Antony Naylor - Alberta, CA
Peter Moxham - Alberta, CA
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US

International Classification:

A61K033/38
A61K033/26
A61K033/24

US Classification:

424/618000, 424/647000, 424/649000

Abstract:

Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

US Patent:

20030194444, Oct 16, 2003

Filed:

Oct 22, 2002

Appl. No.:

10/277362

Inventors:

Robert Burrell - Alberta, CA
Scott Gillis - Concord MA, US
Paul Schechter - Dover MA, US
John Wright - San Antonio TX, US
Kan Lam - San Antonio TX, US
Hua Yin - Alberta, CA

International Classification:

A61K033/38
A61K033/26
A61K033/24

US Classification:

424/618000, 424/647000, 424/649000

Abstract:

Methods of treating skin and integument conditions, particularly with metal-containing compounds, are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.