Kam Hong Leong

US Patent:

6905875, Jun 14, 2005

Filed:

Oct 12, 2001

Appl. No.:

10/398957

Inventors:

Hanry Yu - Irvine CA, US
Kam W. Leong - Ellicott City MD, US
Ser-Mien Chia - Singapore, SG

Assignee:

National University of Singapore - Singapore
Agency for Science, Technology and Research - Centros

International Classification:

C12N011/00
C12N011/02
C12N011/10

US Classification:

435395, 435182, 435 11, 435123, 435180, 4353201, 435325, 435366, 435 691, 435 697, 435174, 536 231, 536 232, 514963, 514970, 264 432

Abstract:

A non-disruptive three-dimensional culture system allows cell growth and proliferation in three dimensions, permitting cell splitting without subjecting cells to disruptive conditions that affect cell structure and functions. An extracellular matrix provides a good environment for culturing or co-culturing anchorage-dependent cells. The cells cultured this manner can be readily used in such applications as cell transplantation, tissue engineering seeding of cells on scaffolds, and other applications that require immediate availability of functioning cells.

US Patent:

6916640, Jul 12, 2005

Filed:

Oct 12, 2001

Appl. No.:

09/975273

Inventors:

Hanry Yu - Irvine CA, US
Kam W. Leong - Ellicott City MD, US
Ser-Mien Chia - Singapore, SG
Andrew C. A. Wan - Singapore, SG

Assignee:

Agency for Science, Technology and Research - Centros
National University of Singapore - Singapore

International Classification:

C12N011/04
C12N011/08

US Classification:

435182, 435177, 435180, 42721334, 514963

Abstract:

A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.

US Patent:

20050202096, Sep 15, 2005

Filed:

Mar 9, 2004

Appl. No.:

10/796902

Inventors:

Jun Li - Singapore, SG
Chai Quek - Singapore, SG
Leong Gan - Singapore, SG
Hanry Yu - Irvine CA, US
Kam Leong - Ellicott City MD, US

International Classification:

A61K009/16
A61K009/50

US Classification:

424490000, 424093700

Abstract:

The invention relates to photo-crosslinkable microcapsules with enhanced properties for encapsulation of bioactive substances. The present invention also relates to a microencapsulation composition and to a method of manufacturing microcapsules. The microcapsule comprise bioactive substances that are encapsulated by a selectively permeable polymeric membrane. The selectively permeable membrane is impermeable to immune system components associated with immune rejection in an animal. A monomer of the selectively permeable polymeric membrane includes a photosensitive cross-linking agent having a cinnamoyl moiety.

US Patent:

20050220891, Oct 6, 2005

Filed:

May 26, 2005

Appl. No.:

11/137483

Inventors:

Hanry Yu - Irvine CA, US
Kam Leong - Ellicott City MD, US
Ser-Mien Chia - Singapore, SG
Andrew Wan - Singapore, SG

Assignee:

Agency for Science, Technology and Research - Singapore
National University of Singapore - Singapore

International Classification:

A61K009/16
A61K009/50

US Classification:

424490000, 435404000

Abstract:

A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.

US Patent:

20140178465, Jun 26, 2014

Filed:

Feb 28, 2014

Appl. No.:

14/194559

Inventors:

- STANFORD CA, US
- BALTIMORE MD, US
Eric Churchill - Long Beach CA, US
Kam W. Leong - Durham NC, US

Assignee:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - STANFORD CA
JOHNS HOPKINS UNIVERSITY - BALTIMORE MD

International Classification:

A61K 9/14
A61K 45/06
A61K 31/78

US Classification:

424450, 424 7831

Abstract:

A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.