Kam W Leong

US Patent:

6376644, Apr 23, 2002

Filed:

Sep 1, 2000

Appl. No.:

09/654326

Inventors:

Hai-Quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Baltimore MD
James P. English - Chelsea AL

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

C08G 7904

US Classification:

528398, 427 7837, 427426, 427486, 523111, 523113, 525538, 528352, 528400, 623 1, 623 12, 623 16 C

Abstract:

Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is âOâ or âNRââ, where Râ is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M and M are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is âOâ, âSâ or âNRââ, where Râ is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

US Patent:

6403675, Jun 11, 2002

Filed:

Apr 30, 1998

Appl. No.:

09/070204

Inventors:

Wenbin Dang - Ellicott City MD
Hai-quan Mao - Towson MD
Irina Kadiyala - Baltimore MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Ellicott City MD
James P. English - Chelsea AL

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
Johns Hopkins University - Baltimore MD

International Classification:

A61K 3180

US Classification:

523113, 523111, 523124, 524610, 528359, 528356, 528400, 424486, 424 7808, 623 1

Abstract:

Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and Râ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; Râ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, Râ or Râ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

US Patent:

6419709, Jul 16, 2002

Filed:

Oct 2, 1998

Appl. No.:

09/165373

Inventors:

Hai-quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Baltimore MD
Wensin Dang - Baltimore MD
James P. English - Chelsea AL
David P. Nowotnik - Kingsville MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
John Hopkins University School of Medicine - Baltimore MD

International Classification:

C08G 7902

US Classification:

623 2358, 623 2359, 528340, 528272, 528287, 528398

Abstract:

An essentially non-osteoconductive medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; x is 1; and n is 3-7,500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

US Patent:

6485737, Nov 26, 2002

Filed:

Nov 27, 2000

Appl. No.:

09/722848

Inventors:

Hai-quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Zhong Zhao - Ellicott City MD
Wenbin Dang - Ellicott City MD
James P. English - Chelsea AL
David P. Nowotnik - Kingsville MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD

International Classification:

A61F 202

US Classification:

424426, 424501, 5147723, 428402

Abstract:

A medical device is described comprising a biodegradable terephthalate copolymer comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; Râ is an aliphatic, aromatic or heterocyclic residue; x is 1; and n is 3-7, 500, where the biodegradable polymer is sufficiently pure to be biocompatible and is capable of forming biocompatible residues upon biodegradation. Compositions containing the copolymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the copolymers, are also described.

US Patent:

6548302, Apr 15, 2003

Filed:

Jun 18, 1999

Appl. No.:

09/336390

Inventors:

Hai-Quan Mao - Towson MD
Kevin Y. Lin - Placentia CA
Bart S. Hendriks - Cambridge MA
Kam W. Leong - Ellicott City MD
Michael F. Haller - Baltimore MD

Assignee:

Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K 4800

US Classification:

435455, 424450, 435325, 435375, 514 44

Abstract:

The present invention relates to compositions and methods for delivery of nucleic acids. In particular, the invention provides a polymeric delivery formulation including a nucleic acid to be transfected into a host cell, formulated in a biodegradable polymer having phosphorous-based linkages.

US Patent:

6600010, Jul 29, 2003

Filed:

Aug 2, 2001

Appl. No.:

09/921297

Inventors:

Hai-Quan Mao - Towson MD
Kam W. Leong - Ellicott City MD
Wenbin Dang - Baltimore MD
Hungnan Lo - Shaker Heights OH
Zhong Zhao - Baltimore MD
David P. Nowotnik - Kingsville MD
James P. English - Chelsea AL

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
John Hopkins University - Baltimore MD

International Classification:

C08G 7902

US Classification:

528400, 528398, 606278, 523115, 442248, 428378, 424271, 424426

Abstract:

Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula I: wherein R is a divalent organic moiety; Râ is an aliphatic, aromatic or heterocyclic residue; x is 1; and n is 0-5,000, wherein the biodegradable polymer is biocompatible before and upon biodegradation. Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

US Patent:

6797704, Sep 28, 2004

Filed:

Oct 5, 2001

Appl. No.:

09/972725

Inventors:

Kam W. Leong - Ellicott City MD
Michael F. Haller - Baltimore MD
Bernard A. Malavaud - Toulouse, FR
Catherine S. Le Visage - Baltimore MD

Assignee:

The Johns Hopkins University - Baltimore MD

International Classification:

A61K 4800

US Classification:

514 44, 424468, 424482, 424486, 514 2

Abstract:

The present invention features methods of administering a therapeutic agent to a patients lymph nodes by instillation of microparticles or nanoparticles comprising a biocompatible polymer and the therapeutic agent into the patients bladder. The invention also features methods of modulating a patients immune response and methods of systemic delivery of a therapeutic agent systemically using the administration methods of the invention.

US Patent:

6800672, Oct 5, 2004

Filed:

Dec 4, 2001

Appl. No.:

10/011570

Inventors:

Wenbin Dang - Ellicott City MD
Irina Kadiyala - Baltimore MD
Zhong Zhao - Ellicott City MD
James P. English - Chelsea AL
Hai-quan Mao - Towson MD
Kam W. Leong - Ellicott City MD

Assignee:

Guilford Pharmaceuticals, Inc. - Baltimore MD
Johns Hopkins University School of Medicine - Baltimore MD

International Classification:

A61K 3180

US Classification:

523113, 523111, 523124, 524610, 528356, 528359, 528400, 623 1, 424 7808, 424486

Abstract:

Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and Râ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; Râ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, Râ or Râ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.