Jutta Wanner from Tucson, AZ, age 56

Heterocyclic Antiviral Compounds
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US Patent:

20110070190, Mar 24, 2011
Filed:

Sep 24, 2010
Appl. No.:

12/890218
Inventors:

Chris Allen Broka - Las Vegas NV, US
Robert Than Hendricks - San Carlos CA, US
Hans Maag - Sausalito CA, US
David Bernard Smith - San Mateo CA, US
Jutta Wanner - Montclair NJ, US
Assignee:

Roche Palo Alto LLC - Palo Alto CA
International Classification:

A61K 31/4365
C07D 495/04
A61K 31/437
A61K 39/00
A61K 38/21
A61K 38/20
A61K 38/19
A61P 31/14
C12N 5/02
US Classification:

424 852, 544278, 544281, 514301, 4241841, 424 854, 424 851, 435375
Abstract:

The invention discloses 1-N-substituted-6-(hetero)aryl-1H-thieno[3,2-d]pyrimidin-4-one derivatives of formulawherein R, R, Rand Rare as defined herein that inhibit Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

Pyrazolo[1,5A]Pyrimidine Derivatives As Irak4 Modulators
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US Patent:

20120015962, Jan 19, 2012
Filed:

Jul 12, 2011
Appl. No.:

13/180589
Inventors:

Nidhi Arora - Cupertino CA, US
Shaoqing Chen - Bridgewater NJ, US
Johannes Cornelius Hermann - Jersey City NJ, US
Adreas Kuglstatter - Montclair NJ, US
Sharada Shenvi Labadie - Sunnyvale CA, US
Clara Jeou Jen Lin - Palo Alto CA, US
Matthew C. Lucas - Verona NJ, US
Amy Geraldine Moore - Mountain View CA, US
Eva Papp - Palo Alto CA, US
Francisco Xavier Talamas - Livingston NJ, US
Jutta Wanner - Montclair NJ, US
Yansheng Zhai - Nutley NJ, US
International Classification:

A61K 31/519
C07D 495/04
A61P 19/02
A61P 11/00
A61P 11/06
A61P 11/08
C07D 487/04
A61K 31/4365
US Classification:

5142593, 544281, 544278, 546114, 5142601, 514301
Abstract:

Compounds of the formula I or II:wherein X, m, Ar, Rand Rare as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

Thiazolopyrimidine Compounds
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US Patent:

20120252777, Oct 4, 2012
Filed:

Mar 26, 2012
Appl. No.:

13/429484
Inventors:

Johannes Cornelius Hermann - Jersey City NJ, US
Matthew C. Lucas - Verona NJ, US
Kin-Chun Thomas Luk - North Caldwell NJ, US
Fernando Padilla - Verona NJ, US
Jutta Wanner - Montclair NJ, US
Wenwei Xie - Beijing, CN
Xiaohu Zhang - Beijing, CN
International Classification:

A61K 31/519
A61K 31/551
A61K 31/5386
A61P 29/00
A61P 37/00
A61P 19/04
A61P 25/00
A61P 17/06
A61P 3/10
A61P 37/06
A61P 35/00
A61P 11/06
A61P 17/00
A61P 1/04
A61P 1/00
A61P 25/28
A61P 35/02
C07D 513/04
US Classification:

51421021, 544255, 5142601, 540575, 514218, 51425505, 544105, 5142305
Abstract:

The present invention relates to the use of novel pyrrolopyrazine derivatives of formula I:wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Inhibitors Of Bruton's Tyrosine Kinase
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US Patent:

20120295885, Nov 22, 2012
Filed:

May 16, 2012
Appl. No.:

13/472541
Inventors:

Roland Joseph Billedeau - Clifton NJ, US
Rama K. Kondru - Morris Plains NJ, US
Francisco Javier Lopez-Tapia - Mahwah NJ, US
Yan Lou - Glen Ridge NJ, US
Timothy D. Owens - San Carlos CA, US
Yimin Qian - Wayne NJ, US
Kshitij C. Thakkar - Clifton NJ, US
Jutta Wanner - Montclair NJ, US
International Classification:

A61K 31/502
A61P 37/06
A61P 11/06
C07D 405/10
C07D 403/10
C07D 417/10
C07D 413/10
C07D 401/10
A61K 31/4725
C07D 413/14
A61K 31/5377
C07D 471/04
C07D 401/14
C07D 487/04
A61K 31/519
A61K 31/541
A61P 29/00
US Classification:

51421021, 544237, 514248, 546141, 514309, 544119, 5142345, 544 582, 5142282
Abstract:

This application discloses compounds according to generic Formula I:wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

Triazolopyridine Compounds
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US Patent:

20120309746, Dec 6, 2012
Filed:

May 24, 2012
Appl. No.:

13/479730
Inventors:

Johannes Cornelius Hermann - Jersey City NJ, US
Matthew C. Lucas - Verona NJ, US
Kin-Chun Thomas Luk - North Caldwell NJ, US
Fernando Padilla - Verona NJ, US
Jutta Wanner - Montclair NJ, US
Wenwei Xie - Beijing, CN
Xiaohu Zhang - Beijing, CN
International Classification:

C07D 471/04
A61K 31/551
A61P 37/00
A61P 9/00
A61P 3/10
A61P 37/06
A61P 19/02
A61P 35/04
A61P 1/04
A61P 17/00
A61P 25/28
A61P 17/06
A61K 31/437
A61P 35/02
US Classification:

514218, 546119, 514303, 540597
Abstract:

The present invention relates to the use of novel triazolopyridine derivatives of formula I:wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Imidazopyridazine Compounds
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US Patent:

20130109661, May 2, 2013
Filed:

Oct 31, 2012
Appl. No.:

13/665006
Inventors:

Andreas Kuglstatter - Loerrach, DE
Matthew C. Lucas - Lexington MA, US
Fernando Padilla - Verona NJ, US
Jutta Wanner - Montclair NJ, US
Xiaohu Zhang - Suzhou, CN
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
International Classification:

C07D 487/04
A61K 45/06
A61K 31/625
A61K 31/5025
A61K 31/5377
US Classification:

514161, 544236, 514248, 544117, 5142332
Abstract:

The present invention relates to the use of novel compounds of formula I:wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

Pyrrolopyrazone Inhibitors Of Tankyrase
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US Patent:

20130345226, Dec 26, 2013
Filed:

Jun 19, 2013
Appl. No.:

13/921942
Inventors:

Ann Catherine Petersen - Montclair NJ, US
Jutta Wanner - Montclair NJ, US
Lin Yi - Basking Ridge NJ, US
Assignee:

Hoffmann-La Roche Inc. - South San Francisco CA
International Classification:

C07D 487/04
US Classification:

514249, 544350
Abstract:

There are provided compounds of the formulawherein Rand Rare as described herein. The compounds are useful as anticancer agents.

Silanol Based Therapeutic Payloads
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US Patent:

20220184104, Jun 16, 2022
Filed:

Feb 24, 2022
Appl. No.:

17/679775
Inventors:

- Jupiter FL, US
Leslie Odame Ofori - Jupiter FL, US
Jutta Wanner - Palm Beach FL, US
Douglas S. Werner - West Palm Beach FL, US
International Classification:

A61K 31/695
A61K 9/00
A61K 47/60
A61K 47/54
A61K 47/55
A61K 47/64
C07F 15/00
C07F 5/02
C07F 7/08
Abstract:

Described herein in part are silanol based therapeutic payloads comprising a silanol terminus, a divalent spacer moiety, and a drug moiety capable of effecting a target cell or tissue.

Jutta Wanner