Juergen K Naggert from Bar Harbor, ME, age 73

Alströem Syndrome Gene, Gene Variants, Expressed Protein And Methods Of Diagnosis For Alströem Syndrome
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US Patent:

7196171, Mar 27, 2007
Filed:

Oct 20, 2004
Appl. No.:

10/973045
Inventors:

Gayle B. Collin - Trenton ME, US
Jan Marshall - Mount Desert ME, US
Mitchell L. Martin - Vverona NJ, US
Juergen K. Naggert - Bar Harbor ME, US
Patsy M. Nishina - Bar Harbor ME, US
W. Venus So - Nutley NJ, US
Assignee:

Hoffmann-La Roche Inc. - Nutley NJ
The Jackson Laboratory - Bar Harbor ME
International Classification:

C07K 14/00
C07H 21/04
A61K 38/00
US Classification:

530350, 536 231, 514 12
Abstract:

The present invention relates to a nucleic acid sequence linked to Alström syndrome, variants of that nucleic acid sequence, the protein produced by that nucleic acid sequence and screening methods for testing individuals to determine if they are carriers of Alström syndrome.

Alstroem Syndrome Gene, Gene Variants, Expressed Protein And Methods Of Diagnosis For Alstroem Syndrome
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US Patent:

20040001832, Jan 1, 2004
Filed:

Nov 12, 2002
Appl. No.:

10/292576
Inventors:

Gayle Collin - Trenton ME, US
Jan Marshall - Mount Desert ME, US
Mitchell Martin - Verona NJ, US
Juergen Naggert - Bar Harbor ME, US
Patsy Nishina - Bar Harbor ME, US
W. So - Nutley NJ, US
International Classification:

A61K039/395
C12Q001/68
C07H021/04
C12N009/00
C12P021/02
C12N005/06
C07K016/40
US Classification:

424/146100, 435/006000, 435/069100, 435/320100, 435/183000, 435/325000, 530/388260, 536/023200
Abstract:

The present invention relates to a nucleic acid sequence linked to Alström syndrome, variants of that nucleic acid sequence, the protein produced by that nucleic acid sequence and screening methods for testing individuals to determine if they are carriers of Alström syndrome.

Obesity Associated Genes
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US Patent:

57767629, Jul 7, 1998
Filed:

Sep 17, 1996
Appl. No.:

8/714991
Inventors:

Michael North - La Jolla CA
Patsy Nishina - Bar Harbor ME
Konrad Noben-Trauth - Bar Harbor ME
Juergen Naggert - Bar Harbor ME
Assignee:

Sequana Therapeutics, Inc. - La Jolla CA
The Jackson Laboratory - Bar Harbor ME
International Classification:

C07H 2104
C12Q 168
C12N 1570
C12N 1574
US Classification:

4352523
Abstract:

The gene responsible for the autosomal recessive mouse obesity mutation tub was identified by positional cloning. The homologous human gene is also provided. The genes are used to produce tubby protein; in screening for compositions that modulate the expression or function of the tubby protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to obesity, retinal degeneration or cochlear degeneration. The mutation responsible for the tub phenotype is a G to T transversion that abolishes a donor splice site in the 3' coding region and results in a larger transcript containing the unspliced intron. A second, prematurely truncated transcript arises from the introduction of a premature polyadenylation site in the unspliced intron.

Identification Of A Gene Encoding Tulp2, A Retina Specific Protein
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US Patent:

57053804, Jan 6, 1998
Filed:

Sep 4, 1996
Appl. No.:

8/706292
Inventors:

Michael North - San Diego CA
Patsy Nishina - Bar Harbor ME
Juergen Naggert - Bar Harbor ME
Assignee:

Sequana Theraputics, Inc. - La Jolla CA
Jackson Lab. - Bar Harbor ME
International Classification:

C07H 2104
C12N 1563
C12N 1585
US Classification:

4352402
Abstract:

The gene responsible for an autosomal dominant con-rod retinal dystrophy is identified, TULP2. The genes are used to produce the encoded protein; in screening for compositions that modulate the expression or function of TULP2 protein; and in studying associated physiological pathways.

Genes Associated With Retinal Dystrophies
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US Patent:

56865988, Nov 11, 1997
Filed:

Aug 22, 1996
Appl. No.:

8/701380
Inventors:

Michael North - San Diego CA
Patsy Nishina - Bar Harbor ME
Juergen Naggert - Bar Harbor ME
Assignee:

The Jackson Laboratory - Bar Harbor ME
Sequana Therapeutics, Inc. - La Jolla CA
International Classification:

C07H 2104
US Classification:

536 235
Abstract:

The gene responsible for the autosomal recessive retinal degenerative disease RP 14 is identified, TULP1. The genes are used to produce the encoded protein; in screening for compositions that modulate the expression or function of TULP1 protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to retinal degeneration.

Obesity Associated Genes
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US Patent:

57704325, Jun 23, 1998
Filed:

Apr 10, 1996
Appl. No.:

8/630592
Inventors:

Patsy Nishina - Bar Harbor ME
Konrad Noben-Trauth - Bar Harbor ME
Juergen Naggert - Bar Harbor ME
Michael North - La Jolla CA
Assignee:

Sequana Therapeutics - La Jolla CA
Jackson Laboratory - Bar Harbor ME
International Classification:

C07H 2104
C12Q 168
C12N 1574
C12N 1585
US Classification:

4352523
Abstract:

The gene responsible for the autosomal recessive mouse obesity mutation tub was identified by positional cloning. The homologous human gene is also provided. The genes are used to produce tubby protein; in screening for compositions that modulate the expression or function of the tubby protein; and in studying associated physiological pathways. The DNA is further used as a diagnostic for genetic predisposition to obesity, retinal degeneration or cochlear degeneration. The mutation responsible for the tub phenotype is a G to T transversion that abolishes a donor splice site in the 3' coding region and results in a larger transcript containing the unspliced intron. A second, prematurely truncated transcript arises from the introduction of a premature polyadenylation site in the unspliced intron.

Gene Family Associated With Neurosensory Defects
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US Patent:

61145025, Sep 5, 2000
Filed:

Feb 27, 1998
Appl. No.:

9/032365
Inventors:

Michael North - San Diego CA
Patsy Nishina - Bar Harbor ME
Juergen Naggert - Bar Harbor ME
Konrad Noben-Trauth - Rockville MD
Assignee:

AxyS Pharmaceuticals, Inc. - South San Francisco CA
International Classification:

A61K 3817
C07K 14435
C07K 1900
US Classification:

530324
Abstract:

Nucleic acid compositions are provided that encode a family of mammalian proteins expressed in the retina and brain. Members of the gene family are genetically linked to various neurosensory defects, including cochlear degeneration, peripheral retinal degeneration and cone-rod retinal dystrophy. The nucleic acid compositions find use in identifying DNA sequences encoding homologous or related proteins; for production of the encoded protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of neurosensory defects, identification of retinal cells based on expression, and the like. The DNA is further used as a diagnostic for genetic predisposition to the linked neurosensory defect.

Juergen K Naggert