June M Chan

US Patent:

20120121618, May 17, 2012

Filed:

Feb 12, 2010

Appl. No.:

13/201426

Inventors:

Philip W. Kantoff - Brookline MA, US
William K. Oh - Pleasantville NY, US
June M. Chan - Oakland CA, US
Wanling Xie - Newton MA, US
Miyako Abe - Brookline MA, US
Lorelei A. Mucci - Newton MA, US

International Classification:

C12Q 1/68
G01N 33/53
A61K 31/573
A61K 45/00
A61K 38/44
B65D 71/00
A61P 39/06
A61P 37/04
H01J 49/26
B01J 19/12
G06Q 50/24
B65D 85/00
C40B 30/10
A61P 35/00

US Classification:

4241841, 506 12, 435 611, 436501, 514179, 424 944, 250282, 2504921, 705 3, 2064595, 206232

Abstract:

The disclosure features methods and compositions for determining whether a male subject has, or is at an increased risk of developing, an aggressive form of prostate cancer. The disclosure also features methods for adjusting a treatment regimen (e.g., discontinuing a therapy comprising an antioxidant) or administering a therapy that does not contain an antioxidant for a male subject in view of one or both of an MnSOD2 genotype status and an elevated level of an antioxidant in a biological sample obtained from the male subject. Also featured are methods for reducing superoxide levels in a subject based on one or both of an MnSOD2 genotype status and an elevated level of an antioxidant in a biological sample obtained from the male subject.