Jun J Xu

Author:

Jun Xu

ISBN #:

7507518701

US Patent:

7781414, Aug 24, 2010

Filed:

Apr 1, 2004

Appl. No.:

10/551667

Inventors:

Patrick Y. Lu - Rockville MD, US
Frank Y. Xie - Germantown MD, US
Martin C. Woodle - Bethesda MD, US
Yijia Liu - Gaithersburg MD, US
Quinn Q. Tang - Gaithersburg MD, US
Jun Xu - Germantown MD, US

Assignee:

Intradigm Corporation - Palo Alto CA

International Classification:

A61K 31/70
C07H 21/04
C07H 21/00
C12P 19/34

US Classification:

514 44, 536 231, 536 245, 536 253, 435 911

Abstract:

The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.

US Patent:

8344053, Jan 1, 2013

Filed:

Sep 9, 2010

Appl. No.:

12/878515

Inventors:

Wei Xu - Greenbelt MD, US
Jun Xu - Greenbelt MD, US
Gregory D. Cooper - Arlington VA, US

Assignee:

Pixelligent Technologies, LLC - Baltimore MD

International Classification:

C08K 3/10
H01R 43/00

US Classification:

524403, 29825

Abstract:

Domain segregation of polymer blends or block copolymers in the presence of thermal conducting high aspect ratio nanocrystals leads to preferential placement of conductive filler either inside one domain, which promote the self-assembly of a thermal and/or electrical conducting pathway composed of high aspect ratio filler. The self-assembly of such thermal and/or electrical conducting pathway effectively enhances the thermal and/or electrical conductivity of the composite with significantly less amount of filler.

US Patent:

8592511, Nov 26, 2013

Filed:

Apr 25, 2011

Appl. No.:

13/064905

Inventors:

Zehra Serpil Gonen Williams - Lanham MD, US
Yijun Wang - Greenbelt MD, US
Robert J. Wiacek - Silver Spring MD, US
Xia Bai - Olney MD, US
Linfeng Gou - Greenbelt MD, US
Selina I. Thomas - Hyattsville MD, US
Wei Xu - Greenbelt MD, US
Jun Xu - Frederick MD, US
Rakesh Patel - Lawrenceville NJ, US

Assignee:

Pixelligent Technologies, LLC - Baltimore MD

International Classification:

C08K 3/18
A61K 47/32

US Classification:

524432, 5147724

Abstract:

Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.

US Patent:

20030138407, Jul 24, 2003

Filed:

Nov 4, 2002

Appl. No.:

10/286956

Inventors:

Patrick Lu - Gaithersburg MD, US
Martin Woodle - Bethesda MD, US
Frank Xie - Rockville MD, US
Jun Xu - Rockville MD, US
Quinn Tang - Rockville MD, US

International Classification:

A61K048/00
C12N015/86

US Classification:

424/093200, 514/044000, 435/456000

Abstract:

It has been found that certain synthetic vectors and nucleic acid sequences that encode viral genomic sequences can, for example, be administered to a subject repeatedly as a vehicle for effectively delivering one or more therapeutic nucleic acid molecules or polypeptides to a cell or tissue. Accordingly, the disclosed nucleic acid delivery vehicles can be used, for instance, as part of a therapeutic regimen that involves an ongoing use of a therapeutic nucleic acid molecule or polypeptide.

US Patent:

20060211637, Sep 21, 2006

Filed:

Aug 6, 2003

Appl. No.:

10/523714

Inventors:

Martin Woodle - Bethesda MD, US
Patrick Lu - Rockville MD, US
Qingquan Tang - Gaithersburg MD, US
Jun Xu - Germantown MD, US
Frank Xie - Germantown MD, US

Assignee:

Intradigm Corporation - Rockville MD

International Classification:

A61K 48/00
C12N 15/87
C08L 89/00

US Classification:

514044000, 435455000, 525054100

Abstract:

Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.

US Patent:

20070203082, Aug 30, 2007

Filed:

Apr 26, 2004

Appl. No.:

10/554442

Inventors:

Quinn Tang - Gaithersburg MD, US
Patrick Lu - Rockville MD, US
Frank Xie - Germantown MD, US
Yija Liu - Gaithersburg MD, US
Jun Xu - Germantown MD, US
Martin Woodle - Bethesda MD, US

Assignee:

Intradigm Corporation - Rockville MD

International Classification:

A61K 48/00
C12Q 1/70
C12Q 1/68
C07H 21/02

US Classification:

514044000, 435005000, 435006000, 536023100

Abstract:

The present invention provides compositions and methods that are useful for the treatment of severe acute respiratory syndrome (SARS). More specifically, nucleic acid agents such as siRNA molecules and their analogues that target respiratory infections including SARS coronavirus and their methods of use are described, for clinical treatments of SARS, respiratory viral infections, for prevention and treatment of respiratory infections as needed for bio-defense, for treatment of respiratory diseases, and for discovery of therapeutic targets for respiratory diseases and infections.

US Patent:

20070219118, Sep 20, 2007

Filed:

Nov 2, 2006

Appl. No.:

11/591611

Inventors:

Patrick Lu - Gaithersberg MD, US
Martin Woodle - Bethesda MD, US
Frank Xie - Rockville MD, US
Jun Xu - Rockville MD, US
Quinn Tang - Rockville MD, US

Assignee:

INTRADIGM CORPORATION - ROCKVILLE MD

International Classification:

A61K 31/7052
A61K 38/00

US Classification:

514002000, 514044000

Abstract:

It has been found that certain synthetic vectors and nucleic acid sequences that encode viral genomic sequences can, for example, be administered to a subject repeatedly as a vehicle for effectively delivering one or more therapeutic nucleic acid molecules or polypeptides to a cell or tissue. Accordingly, the disclosed nucleic acid delivery vehicles can be used, for instance, as part of a therapeutic regimen that involves an ongoing use of a therapeutic nucleic acid molecule or polypeptide.

US Patent:

20100182947, Jul 22, 2010

Filed:

Nov 25, 2009

Appl. No.:

12/626383

Inventors:

Je-Hong Jong - North Potomac MD, US
Jun Xu - Germantown MD, US

International Classification:

H04B 7/185

US Classification:

370316

Abstract:

Various approaches are introduced to provide link adaptation to maximize the resource utilization of the satellite network: (i) a method to adapt the transmission rate for packet voice and data traffics; (ii) a method to control the transmit power of packet voice and data channels; and (iii) a method to accomplish the feedback loop in a secured and correct manner.