- Tarrytown NY, US Joshua Backman - Tarrytown NY, US Alexander Li - Tarrytown NY, US Lauren Gurski - Tarrytown NY, US Julie E. Horowitz - Tarrytown NY, US Katherine Siminovitch - Tarrytown NY, US Goncalo Abecasis - Tarrytown NY, US Aris Baras - Tarrytown NY, US
International Classification:
C12N 15/113 C12Q 1/6883 A61P 29/00
Abstract:
The present disclosure provides methods of treating subjects having an inflammatory disease, and methods of identifying subjects having an increased risk of developing an inflammatory disease.
Methods Of Treating Skin Cancer With Carboxypeptidase Vitellogenic Like (Cpvl) Inhibitors
- Tarrytown NY, US Julie Horowitz - Tarrytown NY, US Stefan Semrau - Tarrytown NY, US Goncalo Abecasis - Tarrytown NY, US Gavin Thurston - Tarrytown NY, US Eric Jorgenson - Tarrytown NY, US Aris Baras - Tarrytown NY, US
International Classification:
A61K 31/506 C07K 16/28 A61K 31/713
Abstract:
The present disclosure provides methods of treating a subject having skin cancer or preventing a subject from developing skin cancer, and methods of identifying subjects having an increased risk of developing skin cancer.
Methods Of Treating Asthma With Solute Carrier Family 27 Member 3 (Slc27A3) Inhibitors
- Tarrytown NY, US Joshua Backman - Tarrytown NY, US Alexander Li - Tarrytown NY, US Goncalo Abecasis - Tarrytown NY, US Julie Horowitz - Tarrytown NY, US Katherine Siminovitch - Tarrytown NY, US Aris Baras - Tarrytown NY, US
International Classification:
C12Q 1/6883 A61K 31/7088
Abstract:
The present disclosure provides methods of treating a subject having asthma or at risk of developing asthma, and methods of identifying subjects having an increased risk of developing asthma.
Single Immunoglobulin Interleukin-1 Receptor Related (Sigirr) Variants And Uses Thereof
- Tarrytown NY, US Julie Horowitz - Tarrytown NY, US
International Classification:
C12Q 1/6883
Abstract:
The disclosure provides nucleic acid molecules, including cDNA, comprising an alteration that encodes a truncated human Single Immunoglobulin Interleukin-1 Receptor Related (SIGIRR) protein. The disclosure also provides isolated and recombinant human SIGIRR protein variants that comprise a truncation at a position corresponding to position 215. The truncation, and the nucleic acid molecules encoding this change, associate with early-onset inflammatory bowel disease (EO-IBD). The disclosure also provides methods for determining whether a subject has or has a risk of developing EO-IBD, based on the identification of such alterations in the nucleic acid molecules encoding SIGIRR.
The effect was also much stronger in males than females. We have this thread showing that a decrease in ACE2 expression is protective against SARS-CoV-2 infections, said lead-author Julie Horowitz. Thats really useful when thinking about ACE2 as a therapeutic target because now we know that blo
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