Judith A Thomas

Author:

Judith Thomas

ISBN #:

0553345176

Author:

Judith Thomas

ISBN #:

0553344692

Author:

Judith Thomas

ISBN #:

0553345966

Author:

Judith Thomas

ISBN #:

0553346873

Author:

Judith Thomas

ISBN #:

0553348035

Author:

Judith Thomas

ISBN #:

0553348043

Author:

Judith Thomas

ISBN #:

0553348558

Author:

Judith Thomas

ISBN #:

0553352059

US Patent:

7125553, Oct 24, 2006

Filed:

Aug 26, 1999

Appl. No.:

09/383695

Inventors:

David M. Neville - Bethesda MD, US
Stuart Knechtle - Oregon WI, US
Judith M. Thomas - Birmingham AL, US

Assignee:

The United States of America as represented by the Department of Health and Human Services c/o Centers for Disease Control and Prevention - Washington DC
The UAB Research Foundation - Birmingham AL

International Classification:

A61K 39/44
A61K 39/395

US Classification:

4241831, 4241731, 4241841

Abstract:

Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease. Also provided is a method of inhibiting a rejection response by inducing immune tolerance in a recipient to a foreign mammalian donor tissue or cells, comprising the steps of: a) exposing the recipient to an immunotoxin so as to reduce the recipients's peripheral blood T-cell lymphocyte population by at least 80%, wherein the immunotoxin is anti-CD3 antibody linked to a diphtheria protein toxin, wherein the protein has a binding site mutation; and b) transplanting the donor cells into the recipient, whereby a rejection response by the recipient to the donor organ cell is inhibited, and the host is tolerized to the donor cell.

US Patent:

7288254, Oct 30, 2007

Filed:

Mar 16, 2001

Appl. No.:

09/810999

Inventors:

David M. Neville - Bethesda MD, US
Judith T. Thomas - Birmingham AL, US
Francis T. Thomas - Birmingham AL, US

Assignee:

The United States of America as represented by the Secretary, Department of Health and Human Services, NIH - Washington DC

International Classification:

A61K 39/00

US Classification:

4241781, 4241921, 424 9371, 4241771, 514866, 5303873, 53038813, 5303896, 5303917

Abstract:

The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tolerance inducing treatment regimen, used optionally with adjunct immunosuppressive agents, prevents pancreatic islet cell rejection while maintaining long term islet cell function following xenogeneic and allogeneic pancreatic islet cell transplantation. Thus, the methods of the present invention provide a means for treating diabetes, wherein the need for exogenous insulin or immunosuppressive agents is decreased or eliminated. Also provided is a method of inhibiting a rejection response of a transplant recipient, comprising administering an immunotoxin during the peritransplant period, thereby transiently reducing the number of T-cell lymphocytes and promoting long-term survival of the transplant.

US Patent:

20030185825, Oct 2, 2003

Filed:

May 9, 2003

Appl. No.:

10/435567

Inventors:

David Neville - Bethesda MD, US
Judith Thomas - Birmingham AL, US
Jerry Thompson - Frenchville PA, US
Huaizhong Hu - Singapore, SG
Shenglin Ma - Birmingham AL, US

International Classification:

A61K039/395
A61K045/00
A61K031/573
A61K031/365
A61K031/22

US Classification:

424/144100, 530/391100, 514/179000, 514/469000, 424/093700, 514/546000

Abstract:

Provided are novel DT- and ETA-based immunotoxins and a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 pathway, or derivatives thereof under conditions such that the disorder is treated. Thus, the present method can treat graft-versus-host disease. Also provided is a method of inhibiting a rejection response by inducing immune tolerance in a recipient to a foreign mammalian donor tissue or cells, comprising the steps of: a) exposing the recipient to an immunotoxin so as to reduce the recipients's peripheral blood T-cell lymphocyte population by at least 80%, wherein the immunotoxin is anti-CD3 antibody linked to a diphtheria protein toxin, wherein the protein has a binding site mutation; and b) transplanting the donor cells into the recipient, whereby a rejection response by the recipient to the donor organ cell is inhibited, and the host is tolerized to the donor cell.