Judith C Sporn

US Patent:

20120171225, Jul 5, 2012

Filed:

Jul 2, 2010

Appl. No.:

13/380324

Inventors:

Andreas Ladurner - Neckargemünd, DE
Judith Sporn - Chicago IL, US
Thomas Muley - Morlenbach, DE

International Classification:

A61K 39/395
G01N 33/53
C40B 30/06
C07K 16/18
A61P 35/00
C12Q 1/68
C40B 30/04

US Classification:

4241721, 435 612, 435 71, 436501, 506 9, 5303891, 506 10

Abstract:

The present invention relates to a method for diagnosing the risk of cancer recurrence in a mammalian patient, comprising detecting the expression of macroH2A1.1 and/or macroH2A2 in a biological sample obtained from said patient, wherein a low or reduced expression of said macroH2A1.1 and/or macroH2A2 is indicative for an increased risk of cancer recurrence in said patient. The present invention is further directed at improved methods for treating cancer, in particular breast and/or lung cancer, based on said diagnostic method.