Joshua L Santarpia

US Patent:

20180028686, Feb 1, 2018

Filed:

Mar 30, 2017

Appl. No.:

15/474800

Inventors:

Charles Jeffrey Brinker - Albuquerque NM, US
Eric C. Carnes - Albuquerque NM, US
Carlee Erin Ashley - Albuquerque NM, US
Joshua Santarpia - Albuquerque NM, US
Adrienne Celeste Greene - Albuquerque NM, US
Oscar Negrete - Pleasanton CA, US
Steven Branda - Livermore CA, US
Ayse Muniz - Albuquerque NM, US
Jacob Ongundi Agola - Albuquerque NM, US
Kimberly Butler - Albuquerque NM, US

International Classification:

A61K 48/00
A61K 9/50
A61K 31/7088
A61K 45/06

Abstract:

The present disclosure relates to the delivery of polynucleotides and/or oligonucleotides using silica delivery platforms, e.g., silica carriers or protocells. In particular, in the present disclosure, polynucleotides in the form of plasmids expressing siRNA may be administered as cargo in the silica delivery platform to a patient or subject to inhibit and/or treat cancer in a patient. In one aspect, the silica delivery platform that have been charged with cargo comprising plasmid DNA (in particular, CRISPR ds plasmid DNA) which expresses siRNA, shRNA, mRNA and other RNA which may be used to administer these plasmids to patients in order to effect inhibition of cancer cells (especially including apoptosis of those cancer cells) and effective and/or prophylaxis of cancer, as well as numerous pathogens, including viruses, bacteria, fungi, and/or other disease states and/or conditions. In another aspect, the silica delivery platform comprises a biological package (e.g., plasmid nucleic acid, such as a for a CRISPR/Cas system) that interacts with a genomic sequence to either activate or inhibit gene expression. Such vehicles can be employed to control gene activation and repression in a host (e.g., a patient) and/or a pathogen.

Address:

7719 Ramona Ave NW, Albuquerque, NM 87114

Phone:

443 567-5695

VIN:

1FAHP2FW2CG101130

Make:

FORD

Model:

TAURUS

Year:

2012