University Hosp/Clin Pulmnry Me 200 Hawkins Dr Suite C33Gh, Iowa City, IA 52242 319 384-5401 (Phone)
Certifications:
Critical Care Medicine, 1995 Internal Medicine, 2005 Pulmonary Disease, 1994
Awards:
Healthgrades Honor Roll
Languages:
English Hebrew
Hospitals:
University Hosp/Clin Pulmnry Me 200 Hawkins Dr Suite C33Gh, Iowa City, IA 52242
University of Iowa Hospital and Clinics 200 Hawkins Drive, Iowa City, IA 52242
Education:
Medical School University of Central Venezuela / Luis Razetti School of Medicine Medical School Dallas Co Hp Parkland Mem Medical School Presbyterian Hospital Medical School University Iowa Hosps and Clinics
Dr. Zabner graduated from the Univ Central De Venezuela, Esc De Med Luis Razetti, Caracas in 1986. He works in Iowa City, IA and specializes in Pulmonary Critical Care Medicine. Dr. Zabner is affiliated with University Of Iowa Hospitals & Clinics.
John A. Chiorini - Kensington MD, US Robert M. Kotin - Bethesda MD, US Beverly Davidson - North Liberty IA, US Joseph Zabner - Iowa City IA, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC University of Iowa Research Foundation - Iowa City IA
The present invention provides methods of delivering nucleic acids to specific regions, tissues and cell types of the CNS. More particularly the invention provides methods of delivering nucleic acids to cells of the CNS such as cerebellar cells and ependymal cells. The invention also provides methods of delivering nucleic acids to cells of the lung such as alveolar cells using AAV5 vectors and particles.
Cftr With A Partially Deleted R Domain And Uses Thereof
The present invention offers new therapies for treating Cystic Fibrosis (CF), that are based on novel DNA molecules and proteins encoded by the DNA molecules. The present invention features DNA molecules encoding CFTR having a partially deleted R domain. The partial deletions in the R domain are between residues 708 and 835 of the wild-type CFTR.
Use Of Xylitol To Reduce Ionic Strength And Activate Endogenous Antimicrobials For Prevention And Treatment Of Infections
Michael Welsh - Riverside IA, US Joseph Zabner - Iowa City IA, US
International Classification:
A61K031/045
US Classification:
514/738000
Abstract:
A method for killing infectious microbial cells by exposing the microbial cells to endogenous antimicrobial compounds. Activation of the antimicrobials is achieved by addition of low permeability, non-ionic osmolytes to lower ionic strength in body fluids where the antimicrobials have been previously suppressed by alteration of ionic transport (increase in salt concentration). The method can be used to treat cystic fibrosis. Cystic fibrosis causes elevated salt concentrations in the airway surface liquid (ASL) occur due to the impaired chloride transport across the epithelia. Xylitol has been found to be an effective low permeability, non-ionic osmolyte for use in the present invention.
Use Of Xylitol To Reduce Ionic Strength And Activate Endogenous Antimicrobials For Prevention And Treatment Of Infections
Michael Welsh - Riverside IA, US Joseph Zabner - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
International Classification:
A61K031/045
US Classification:
514/738000
Abstract:
A method for killing infectious microbial cells by exposing the microbial cells to endogenous antimicrobial compounds. Activation of the antimicrobials is achieved by addition of low permeability, non-ionic osmolytes to lower ionic strength in body fluids where the antimicrobials have been previously suppressed by alteration of ionic transport (increase in salt concentration). The method can be used to treat cystic fibrosis. Cystic fibrosis causes elevated salt concentrations in the airway surface liquid (ASL) occur due to the impaired chloride transport across the epithelia. Xylitol has been found to be an effective low permeability, non-ionic osmolyte for use in the present invention.
Use Of Xylitol To Reduce Ionic Strength And Activate Endogenous Antimicrobials For Prevention And Treatment Of Infections
Michael Welsh - Riverside IA, US Joseph Zabner - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - Iowa City IA
International Classification:
A61K 31/045
US Classification:
514738000
Abstract:
A method for killing infectious microbial cells by exposing the microbial cells to endogenous antimicrobial compounds. Activation of the antimicrobials is achieved by addition of low permeability, non-ionic osmolytes to lower ionic strength in body fluids where the antimicrobials have been previously suppressed by alteration of ionic transport (increase in salt concentration). The method can be used to treat cystic fibrosis. Cystic fibrosis causes elevated salt concentrations in the airway surface liquid (ASL) occur due to the impaired chloride transport across the epithelia. Xylitol has been found to be an effective low permeability, non-ionic osmolyte for use in the present invention.
Cftr With A Partially Deleted R Domain And Uses Thereof
Michael J. Welsh - Riverside IA, US Lynda S. Ostedgaard - Iowa City IA, US Joseph Zabner - Iowa City IA, US
Assignee:
UNIVERSITY OF IOWA RESEARCH FOUNDATION - IOWA CITY IA
International Classification:
C07K 14/705
US Classification:
530350
Abstract:
The present invention offers new therapies for treating Cystic Fibrosis (CF), that are based on novel DNA molecules and proteins encoded by the DNA molecules. The present invention features DNA molecules encoding CFTR having a partially deleted R domain. The partial deletions in the R domain are between residues 708 and 835 of the wild-type CFTR.
BOTOND BANFI - North Liberty IA, US Anthony Fischer - Iowa City IA, US Joseph Zabner - Iowa City IA, US Lakshmi Durairaj - Iowa City IA, US Daniel Lorentzen - North Liberty IA, US
The present invention relates to the use of halides and halide salts for the treatment of microbial infections, including those caused by bacteria, fungi and viruses. The present invention takes advantage of endogenous immune function and augments this system using a non-toxic and inexpensive reagent that can be delivered to mucosal surfaces, for example, orally, topically, opthalmically and via inhalation.
Method To Enhance Antimicrobial Activity By Increasing Ph