Joseph Szasz

US Patent:

6875573, Apr 5, 2005

Filed:

Jul 8, 2002

Appl. No.:

10/190967

Inventors:

Carl Fuller - Berkeley Heights NJ, US
Joseph Szasz - Chardon OH, US

Assignee:

Amersham Biosciences Corp - Piscataway NJ

International Classification:

C12Q001/68
C07H021/04

US Classification:

435 6, 536 231, 536 243, 536 2433, 530350

Abstract:

Thermostable DNA polymerases both in native form and having single amino acid substitutions and optionally N-terminal deletions are disclosed. These polymerases exhibit a substantial improvement of DNA sequencing performance compared to Taq DNA polymerase. The instant DNA polymerases also possess improved salt tolerance.

US Patent:

20020055098, May 9, 2002

Filed:

Nov 13, 1998

Appl. No.:

09/191989

Inventors:

JOSEPH SZASZ - CHARDON OH, US
MARIA DAVIS - TWINSBURG OH, US

International Classification:

C12Q001/68

US Classification:

435/006000, 435/183000, 435/196000, 536/024300

Abstract:

Enzymatically active thermostable alkaline phosphatases from , and

US Patent:

56100663, Mar 11, 1997

Filed:

Dec 10, 1993

Appl. No.:

8/166346

Inventors:

Carl W. Fuller - Cleveland Heights OH
Joseph Szasz - Chesterland OH
Frank T. Robb - Silver Spring MD
Kimberly M. Borges - Ellicott City MD
Maria Davis - Twinsburg OH

Assignee:

Amersham Life Science, Inc. - Cleveland OH

International Classification:

C12N 1563
C12N 1511
C12N 1555

US Classification:

4353201

Abstract:

Purified nucleic acid comprising a nucleotide base sequence selected from sequence ID NOS. : 1-8.

US Patent:

59392576, Aug 17, 1999

Filed:

Oct 25, 1996

Appl. No.:

8/738172

Inventors:

Joseph Szasz - Chardon OH
Maria Davis - Twinsburg OH

Assignee:

Amersham Life Science, Inc. - Cleveland OH

International Classification:

C12Q 168
C12Q 142
C12N 916
G01N 3368

US Classification:

435 6

Abstract:

Enzymatically active thermostable alkaline phosphatases from Rhodothermus marinus, Thermus thermophilus, and Thermosipho africanus.

US Patent:

56331380, May 27, 1997

Filed:

May 30, 1995

Appl. No.:

8/452988

Inventors:

Maria Davis - Twinsburg OH
Joseph Szasz - Chesterland OH

Assignee:

Amersham Life Science, Inc. - Cleveland OH

International Classification:

C12Q 168
C07H 2104

US Classification:

435 6

Abstract:

Alkaline phosphatase from Thermus thermophilus has been isolated. The enzyme has a pH optimum of greater than 10. 5 and is stable to heating at 65. degree. C for 1 hour. The claimed invention relates to a method of detecting nucleic acids in a sample by providing a nucleic acid probe labelled with thermostable alkaline phosphatase from Thermus thermophilus; contacting the sample with said labelled nucleic acid; and detecting said nucleic acid in said sample by means of said thermostable alkaline phosphatase.