Joseph C Mcauliffe

US Patent:

7355056, Apr 8, 2008

Filed:

Jun 4, 2004

Appl. No.:

10/861545

Inventors:

Robert Connor - Oceanside CA, US
Joseph McAuliffe - Sunnyvale CA, US

Assignee:

Canji, Inc. - San Diego CA

International Classification:

C07J 1/00
A01N 61/00
A01N 63/00
A61K 38/00
C07H 21/04

US Classification:

552509, 514 1, 514 44, 424 936, 536 5, 536 231, 536 232, 536 2352, 536 245

Abstract:

The present invention provides compounds, compositions and methods that enhance the transfer of an agent into a cell. The agents can include polypeptides, polynucleotides such as genes and antisense nucleic acids, and other molecules. In some embodiments, the agents are modulating agents that can modulate a cellular activity or function when introduced into the cell. The compounds, compositions and methods are useful for introducing agents such as genes into individual cells, as well as cells that are present as a tissue or organ.

US Patent:

7378219, May 27, 2008

Filed:

Nov 26, 2003

Appl. No.:

10/724271

Inventors:

Rasmus B. Jensen - Mountain View CA, US
Bradley R. Kelemen - Menlo Park CA, US
Joseph C. McAuliffe - Sunnyvale CA, US
Wyatt Charles Smith - Tiburon CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

F21L 4/04

US Classification:

43027014, 430945, 430 1, 430 2, 362200, 369288, 428 648

Abstract:

The present invention relates to materials comprising hydrophilic polymers and immobilized proteorhodopsin and the use of such materials as an optical information carrier. The material comprises one or more hydrophilic polymers that are capable to form a homogeneous phase with proteorhodopsin prior to solidification to a solid form. The hydrophilic polymer, for example, is silica sol-gel, gelatin, polyvinylalcohol, agarose, agar, methyl cellulose, polyvinyl acetate, polyvinyl pyrrolidone, polyethylene glycol, or a mixture thereof. The solid material having immobilized proteorhodopsin is deposited on a substrate selected from the group consisting of glass, paper, metal, fabric material, plastic material, and used as an optical data storage material or a fraud-proof carrier. The present invention further provides a security ink comprising proteorhodopsin and one or more hydrophilic polymers.

US Patent:

7381830, Jun 3, 2008

Filed:

Dec 28, 2006

Appl. No.:

11/646784

Inventors:

Joseph C. McAuliffe - Sunnyvale CA, US
Gregory M. Whited - Belmont CA, US
Wyatt Charles Smith - Tiburon CA, US

Assignee:

Genencor International, Inc. - Alto CA

International Classification:

C07F 7/04

US Classification:

556449

Abstract:

The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-diols to the corresponding catechols and the compounds produced thereby. The present invention also provides chemical methods for the conversion of said silane cis-diols and acetonide compounds to epoxy, saturated and otherwise modified derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.

US Patent:

7455998, Nov 25, 2008

Filed:

Mar 3, 2004

Appl. No.:

10/791951

Inventors:

Kurt Friedrich Brandstadt - Frankenmuth MI, US
Thomas Howard Lane - Midland MI, US
John C. Saam - Midland MI, US
Joseph C. McAuliffe - Sunnyvale CA, US

Assignee:

Dow Corning Corporation - Midland MI
Genencor International, Inc. - Palo Alto CA

International Classification:

C12P 9/00
C12N 9/76
C12N 9/20
C12N 9/14

US Classification:

435131, 435213, 435198, 435195

Abstract:

Methods of forming organic molecules comprising contacting a hydrolase enzyme with an organic reactant are provided. Methods for forming an organosilicon molecule comprising contacting a hydrolase enzyme with an organosilicon reactant are also provided.

US Patent:

7456298, Nov 25, 2008

Filed:

Dec 28, 2006

Appl. No.:

11/646945

Inventors:

Joseph C. McAuliffe - Sunnyvale CA, US
Gregory M. Whited - Belmont CA, US
Wyatt Charles Smith - Tiburon CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

C07D 317/50

US Classification:

549214

Abstract:

The present invention is related to cis-diols and biological methods of producing cis-diols. The present invention further relates to processes for subsequently converting such silane cis-diols to the more stable acetonide derivatives, as well as a process for converting silane cis-diols to the corresponding catechols and the compounds produced thereby. The present invention also provides chemical methods for the conversion of said silane cis-diols and acetonide compounds to epoxy, saturated and otherwise modified derivatives. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that is will not be used to interpret or limit the scope or meaning of the claims.

US Patent:

7642077, Jan 5, 2010

Filed:

Dec 7, 2004

Appl. No.:

11/007437

Inventors:

Risha Bond - Mountain View CA, US
Michael C. Jewett - Copenhagen, DK
Joseph C. McAuliffe - Sunnyvale CA, US

Assignee:

Genencor International, Inc. - Palo Alto CA

International Classification:

C12N 11/14
C12N 11/02
C12N 11/04

US Classification:

435176, 435177, 435182

Abstract:

This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three basic residues selected from the group consisting of lysine, arginine, histidine, proline, hydroxyproline, N-methylhistidine, ornithine, taurine, δ-hydroxylysine, and δ-hydroxy-ω-N,N,N trimethyllysine. The invention is also directed to a silica biocomposite comprising co-precipitates of active biocatalysts, silica or organosilicates, and an N-containing organic template molecule. Such silica biocomposites are useful in biocatalysis, and other applications requiring an immobilized biocatalyst. Preferred biocatalysts for this invention are enzymes and whole cells.

US Patent:

7745066, Jun 29, 2010

Filed:

May 1, 2008

Appl. No.:

12/113789

Inventors:

Rasmus B. Jensen - Mountain View CA, US
Bradley R. Kelemen - Menlo Park CA, US
Joseph C. McAuliffe - Sunnyvale CA, US
Wyatt Charles Smith - Tiburon CA, US

Assignee:

Danisco US Inc, - Palo Alto CA

International Classification:

F21L 4/04

US Classification:

430 1, 430 2, 43027014, 430945, 359 3, 362200, 428 648

Abstract:

The present invention relates to materials comprising hydrophilic polymers and immobilized proteorhodopsin and the use of such materials as an optical information carrier. The material comprises one or more hydrophilic polymers that are capable to form a homogeneous phase with proteorhodopsin prior to solidification to a solid form. The hydrophilic polymer, for example, is silica sol-gel, gelatin, polyvinylalcohol, agarose, agar, methyl cellulose, polyvinyl acetate, polyvinyl pyrrolidone, polyethylene glycol, or a mixture thereof. The solid material having immobilized proteorhodopsin is deposited on a substrate selected from the group consisting of glass, paper, metal, fabric material, plastic material, and used as an optical data storage material or a fraud-proof carrier. The present invention further provides a security ink comprising proteorhodopsin and one or more hydrophilic polymers.

US Patent:

7834087, Nov 16, 2010

Filed:

May 23, 2006

Appl. No.:

11/915077

Inventors:

Eric Jude Joffre - Midland MI, US
Joseph Charles McAuliffe - Sunnyvale CA, US

Assignee:

Dow Corning Corporation - Midland MI

International Classification:

C08F 297/04

US Classification:

525 54

Abstract:

Ionically-modified saccharide siloxane copolymers that comprises a reaction product between an ionic monomer or oligomer and a saccharide-siloxane copolymer, wherein the saccharide-siloxane copolymer has a specified formula, are provided. Dispersions, including emulsions, comprising the ionic saccharide-siloxane copolymers, and methods for manufacturing these compositions, dispersions, and emulsions are also provided.