Joseph A Kozlowski

US Patent:

6451797, Sep 17, 2002

Filed:

Feb 28, 2000

Appl. No.:

09/514935

Inventors:

Joseph A. Kozlowski - Princeton NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31501

US Classification:

51425203, 514316, 514318, 514326, 544238, 546187, 546193, 546194, 546212, 546213

Abstract:

Heterocyclic derivatives of di-N-substituted piperazine or 1,4 di-substituted piperidine compounds in accordance with formula I (including all isomers, salts and solvates) wherein wherein one of Y and Z is âNâ and the other is âNâ or âCHâ; X is âOâ, âSâ, âSOâ, âSO â or âCH â; Q is R is alkyl, cycloalkyl, optionally substituted aryl or heteroaryl; R , R and R are H or alkyl; R is alkyl, cyclolalkyl or R is H, alkyl, âC(O)alkyl, arylcarbonyl, âSO alkyl, aryl-sulfonyl âC(O)Oalkyl, aryloxycarbonyl, âC(O)NH-alkyl or aryl-aminocarbonyl, wherein the aryl portion is optionally substituted; R is H or alkyl; and R is H, alkyl, hydroxyalkyl or alkoxyalkyl; are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of treatment are also disclosed.

US Patent:

6498168, Dec 24, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/902849

Inventors:

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D40102

US Classification:

514316, 546186, 546187, 546188, 546189

Abstract:

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R , R , R , R , R , R , R , X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

US Patent:

6838466, Jan 4, 2005

Filed:

Dec 19, 2002

Appl. No.:

10/323511

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Robert Mazzola - Clinton NJ, US
Zhuyan Guo - Scotch Plains NJ, US
Brian J. Lavey - Chatham NJ, US
Lisa Sinning - New Providence NJ, US
Joseph Kozlowski - Princeton NJ, US
Brian McKittrick - New Vernon NJ, US
Neng-Yang Shih - North Caldwell NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314709
C07D21514

US Classification:

514311, 514314, 546175

Abstract:

This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.

US Patent:

7034057, Apr 25, 2006

Filed:

Nov 19, 2003

Appl. No.:

10/716890

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Robert Mazzola - Clinton NJ, US
Zhuyan Guo - Scotch Plains NJ, US
Brian J. Lavey - Chatham NJ, US
Lisa Sinning - New Providence NJ, US
Joseph Kozlowski - Princeton NJ, US
Brian McKittrick - New Vernon NJ, US
Neng-Yang Shih - North Caldwell NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/165
A61K 31/18
A61K 31/21
A61K 31/27

US Classification:

514624, 514601, 514513, 514484

Abstract:

This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combinations thereof.

US Patent:

7067539, Jun 27, 2006

Filed:

Aug 7, 2002

Appl. No.:

10/214897

Inventors:

Joseph A. Kozlowski - Princeton NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Brian J. Lavey - Chatham NJ, US
Razia K. Rizvi - Bloomfield NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
James M. Spitler - Westfield NJ, US
Ling Tong - Warren NJ, US
Ronald L. Wolin - San Diego CA, US
Michael K. Wong - North Brunswick NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/444
A61K 31/435
C07D 213/70
C07D 213/71
C07D 213/89

US Classification:

514347, 514335, 514345, 546255, 546290, 546294

Abstract:

The invention relates to compounds of the formula.

US Patent:

7217732, May 15, 2007

Filed:

Jun 17, 2003

Appl. No.:

10/464174

Inventors:

Joseph A. Kozlowski - Princeton NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Ling Tong - Warren NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/404
C07D 209/04

US Classification:

514418, 548469, 548484, 548486, 548511

Abstract:

A compound of the formula.

US Patent:

7507767, Mar 24, 2009

Filed:

Feb 6, 2002

Appl. No.:

10/072354

Inventors:

Joseph A. Kozlowski - Princeton NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Brian J. Lavey - Chatham NJ, US
Razia K. Rizvi - Bloomfield NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
James M. Spitler - Westfield NJ, US
Ling Tong - Warren NJ, US
Ronald L. Wolin - San Diego CA, US
Michael K. Wong - North Brunswick NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/16
A61K 31/40
A61K 31/435
A61K 31/445
C07D 211/06
C07D 211/68
C07D 207/04
C07D 207/18
C07C 211/01

US Classification:

514615, 514315, 514335, 514422, 514646, 546192, 548560, 564161, 564305

Abstract:

There are disclosed compounds of the formula.

US Patent:

7524842, Apr 28, 2009

Filed:

Jan 16, 2007

Appl. No.:

11/653511

Inventors:

Brian J. Lavey - New Providence NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Guowei Zhou - Livingston NJ, US
Ling Tong - Warren NJ, US
Wensheng Yu - Edison NJ, US
Michael K. C. Wong - North Brunswick NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
Neng-Yang Shih - Lexington MA, US
M. Arshad Siddiqui - Newton MA, US
Kristin E. Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay M. Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US
Razia Rizvi - Bloomfield NJ, US
Lei Chen - Roselle Park NJ, US
De-Yi Yang - Morris Plains NJ, US
Robert Feltz - Parsippany NJ, US
Seong Heon Kim - Livingston NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/428
A61K 31/4015
A61K 31/4166
C07D 209/04
C07D 233/24
C07D 277/34
C07D 417/06

US Classification:

5142278, 514373, 514405, 514414, 544 60, 548209, 5483615, 548465

Abstract:

This invention relates to compounds of the Formula (I):.

Author:

Joseph G. Kozlowski

ISBN #:

0131600370

Author:

Joseph G. Kozlowski

ISBN #:

0916592677