Joseph E Kozlowski

US Patent:

6498168, Dec 24, 2002

Filed:

Jul 11, 2001

Appl. No.:

09/902849

Inventors:

Derek Lowe - Scotch Plains NJ
Wei Chang - Livingston NJ
Joseph Kozlowski - Princeton NJ
Joel G. Berger - Cedar Grove NJ
Robert McQuade - Scotch Plains NJ
Allen Barnett - Pine Brook NJ
Margaret Sherlock - Bloomfield NJ
Wing Tom - Cedar Grove NJ
Sundeep Dugar - Bridgewater NJ
John W Clader - Cranford NJ
Samuel Chackalamannil - East Brunswick NJ
Wang Yuguang - North Brunswick NJ
Stuart W. McCombie - Caldwell NJ
Jayaram R. Tagat - Westfield NJ
Susan F. Vice - Mountainside NJ
Wayne Vaccaro - Yardley PA
Michael J. Green - Skillman NJ
Margaret E. Browne - Bloomfield NJ
Theodros Asberom - West Orange NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D40102

US Classification:

514316, 546186, 546187, 546188, 546189

Abstract:

Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) wherein R, R , R , R , R , R , R , R , X, Y, and Z are as defined herein are muscarinic antagonists useful for treating cognitive disorders such as Alzheimers disease. Pharmaceutical compositions and methods of preparation are also disclosed. Also disclosed are synergistic combinations of compounds of the above formula or other compounds capable of enhancing acetylcholine release with acetylcholinesterase inhibitors.

US Patent:

7105505, Sep 12, 2006

Filed:

Apr 16, 2003

Appl. No.:

10/417391

Inventors:

Qingbei Zeng - Edison NJ, US
Robert G. Aslanian - Rockaway NJ, US
Michael Y. Berlin - Flemington NJ, US
Christopher W. Boyce - Flemington NJ, US
Jianhua Cao - Scotch Plains NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Pietro Mangiaracina - Monsey NY, US
Kevin D. McCormick - Edison NJ, US
Mwangi W. Mutahi - Orange NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Daniel M. Solomon - Edison NJ, US
Wing C. Tom - Cedar Grove NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/495

US Classification:

51421021, 544224, 544336, 546184, 546192, 546193, 546194

Abstract:

Disclosed are novel compounds of the formula.

US Patent:

7417045, Aug 26, 2008

Filed:

Feb 14, 2006

Appl. No.:

11/353609

Inventors:

Gopinadhan N. Anilkumar - Edison NJ, US
Qingbei Zeng - Edison NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Brian F. McGuinness - Plainsboro NJ, US
Douglas W. Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Inc. - Princeton NJ

International Classification:

A61K 31/497
C07D 403/00
C07D 295/00
C07D 241/04

US Classification:

51425212, 544358, 544359

Abstract:

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prod rug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1:.

US Patent:

7482370, Jan 27, 2009

Filed:

Jul 13, 2005

Appl. No.:

11/180863

Inventors:

Wensheng Yu - Edison NJ, US
Ling Tong - Warren NJ, US
Lei Chen - Roselle Park NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Brian J. Lavey - New Providence NJ, US
Neng-Yang Shih - Warren NJ, US
Vincent S. Madison - Mountain Lakes NJ, US
Guowei Zhou - Livingston NJ, US
Peter Orth - New York NY, US
Zhuyan Guo - Scotch Plains NJ, US
Michael K. C. Wong - North Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Seong Heon Kim - Livingston NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/427
A61K 31/4164
A61K 31/4375
C07D 277/22
C07D 409/14
C07D 405/14
C07D 453/02

US Classification:

514373, 514405, 514414, 548209, 5483615, 548465, 546135

Abstract:

This invention relates to compounds of the Formula (I):.

US Patent:

7488745, Feb 10, 2009

Filed:

Jan 16, 2007

Appl. No.:

11/653676

Inventors:

Wensheng Yu - Edison NJ, US
Ling Tong - Warren NJ, US
Lei Chen - Roselle Park NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Brian J. Lavey - New Providence NJ, US
Neng-Yang Shih - Warren NJ, US
Vincent S. Madison - Mountain Lakes NJ, US
Guowei Zhou - Livingston NJ, US
Peter Orth - New York NY, US
Zhuyan Guo - Scotch Plains NJ, US
Michael K. C. Wong - North Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Seong Heon Kim - Livingston NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
M. Arshad Siddiqui - Newton MA, US
Kristin E. Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay M. Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US
Razia Rizvi - Bloomfield NJ, US
Aneta M. Micula - South Amboy NJ, US
Robert Feltz - Parsippany NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/416
A61K 31/428
C07D 209/04
C07D 231/08
C07D 275/04
C07D 417/14
C07D 513/12

US Classification:

514373, 514406, 514414, 548209, 5483615, 548465

Abstract:

This invention relates to compounds of the Formula (I):.

US Patent:

7504424, Mar 17, 2009

Filed:

Jan 17, 2006

Appl. No.:

11/333663

Inventors:

Wensheng Yu - Edison NJ, US
Ling Tong - Warren NJ, US
Lei Chen - Roselle Park NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Brian J. Lavey - New Providence NJ, US
Neng-Yang Shih - Warren NJ, US
Vincent S. Madison - Mountain Lakes NJ, US
Guowei Zhou - Livingston NJ, US
Peter Orth - New York NY, US
Zhuyan Guo - Scotch Plains NJ, US
Michael K. C. Wong - North Brunswick NJ, US
De-Yi Yang - Morris Plains NJ, US
Seong Heon Kim - Livingston NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
M. Arshad Siddiqui - Newton MA, US
Kristin E. Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Umar Faruk Mansoor - Framingham MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay M. Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/416
A61K 31/428
C07D 209/04
C07D 231/08
C07D 275/04
C07D 417/14
C07D 513/12

US Classification:

514373, 514405, 514414, 548209, 5483615, 548465

Abstract:

This invention relates to compounds of the Formula (I):.

US Patent:

7524842, Apr 28, 2009

Filed:

Jan 16, 2007

Appl. No.:

11/653511

Inventors:

Brian J. Lavey - New Providence NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Guowei Zhou - Livingston NJ, US
Ling Tong - Warren NJ, US
Wensheng Yu - Edison NJ, US
Michael K. C. Wong - North Brunswick NJ, US
Bandarpalle B. Shankar - Branchburg NJ, US
Neng-Yang Shih - Lexington MA, US
M. Arshad Siddiqui - Newton MA, US
Kristin E. Rosner - Watertown MA, US
Chaoyang Dai - Acton MA, US
Janeta Popovici-Muller - Waltham MA, US
Vinay M. Girijavallabhan - Watertown MA, US
Dansu Li - Watertown MA, US
Razia Rizvi - Bloomfield NJ, US
Lei Chen - Roselle Park NJ, US
De-Yi Yang - Morris Plains NJ, US
Robert Feltz - Parsippany NJ, US
Seong Heon Kim - Livingston NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/428
A61K 31/4015
A61K 31/4166
C07D 209/04
C07D 233/24
C07D 277/34
C07D 417/06

US Classification:

5142278, 514373, 514405, 514414, 544 60, 548209, 5483615, 548465

Abstract:

This invention relates to compounds of the Formula (I):.

US Patent:

7566718, Jul 28, 2009

Filed:

Feb 14, 2006

Appl. No.:

11/354328

Inventors:

Michael K. C. Wong - North Brunswick NJ, US
Youheng Shu - Blue Bell PA, US
Wensheng Yu - Edison NJ, US
Stuart B. Rosenblum - West Orange NJ, US
Joseph A. Kozlowski - Princeton NJ, US
Brian F. McGuinness - Plainsboro NJ, US
Yuefei Shao - Princeton NJ, US
Douglas W. Hobbs - Yardley PA, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia Drug Discovery, Inc. - Princeton NJ

International Classification:

A61K 31/497
C07D 401/00
C07D 403/00
C07D 405/00
C07D 409/00

US Classification:

51425301, 544360, 544364

Abstract:

The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers, racemates or prodrug of said compound, or pharmaceutically acceptable salts, solvates or esters of said compound, or of said prodrug, said compound having the general structure shown in Formula 1:.

Address:

1221 Ave Of The Americas, New York, NY 10020

Phone:

315 638-4124

VIN:

JH4CW2H62BC001246

Make:

ACURA

Model:

TSX SPORT WAGON

Year:

2011

Author:

Joseph G. Kozlowski

ISBN #:

0131600370

Author:

Joseph G. Kozlowski

ISBN #:

0916592677