Joseph Anders Beavo from 18927 35Th Dr SE, Bothell, WA 98012, age 81, Phone: 425 489-0197

Us Patents

Human Cgmp-Stimulated Cyclic Nucleotide Phosphodiesterase
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US Patent:

6642040, Nov 4, 2003
Filed:

Jun 18, 2001
Appl. No.:

09/883825
Inventors:

Joseph A. Beavo - Seattle WA
Kelley J. Bentley - Seattle WA
Harry Charbonneau - W. Lafayette IN
William K. Sonnenburg - Seattle WA
Assignee:

The Board of Regents of the University of Washington - Seattle WA
International Classification:

C12N 916
US Classification:

435196, 536 232
Abstract:

The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

Dna Encoding Mammalian Phosphodiesterases
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US Patent:

7122363, Oct 17, 2006
Filed:

Oct 30, 2003
Appl. No.:

10/697894
Inventors:

Joseph A. Beavo - Seattle WA, US
Kelley J. Bentley - Seattle WA, US
Harry Charbonneau - W. Lafayette IN, US
William K. Sonnenburg - Seattle WA, US
Assignee:

The Board of Regents of the University of Washington - Seattle WA
International Classification:

C12N 9/16
C12N 1/21
C12N 5/22
C07H 21/04
US Classification:

435196, 4352523, 435325, 536 232
Abstract:

The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

Pdes And Uses Thereof
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US Patent:

7138259, Nov 21, 2006
Filed:

Sep 12, 2001
Appl. No.:

10/380437
Inventors:

Joseph A. Beavo - Seattle WA, US
Thomas Seebeck - Ortschwaben, CH
Scott Haydn Soderling - Beaverton OR, US
Ana Rascon - Caracas, VE
Roya Zoraghi - Nashville TN, US
Stefan Kunz - Bern, CH
Kewei Gong - Los Angeles CA, US
Natalie Glavas - Daly City CA, US
Assignee:

University of Washington - Seattle WA
University of Bern - Bern
International Classification:

C12N 9/16
C12N 15/79
C12N 15/80
C12N 15/81
C12Q 1/68
US Classification:

435196, 4352523, 4353201, 536 232, 436 6
Abstract:

The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

Screening Methods To Identify Compounds That Modulate Type I Phosphodiesterase (Pde) Activity
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US Patent:

7179614, Feb 20, 2007
Filed:

Sep 14, 2001
Appl. No.:

10/380393
Inventors:

Robert Margolskee - Upper Montclair NJ, US
Joseph Beavo - Seattle WA, US
Assignee:

Mount Sinai School of Medicine - New York NY
University of Washington - Seattle WA
International Classification:

C12Q 1/44
US Classification:

435 19
Abstract:

The present invention relates to novel methods of signal transduction in cells. In particular, the invention relates to signal transduction via a class of enzymes known as phosphodiesterase enzymes or PDEs. The invention also relates to a class of signaling molecules known as G-coupled protein receptors (GCPRs) and G-proteins. The invention provides novel methods to screen for and identify G-proteins and other compounds which modulate signaling by these two classes of proteins. In particular, the relates to novel assays which identify compounds that modulate (e. g. , enhance or inhibit) binding between a PDE polypeptide and an effector activation domain of a G-protein.

Pdes And Uses Thereof
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US Patent:

7598067, Oct 6, 2009
Filed:

Jun 1, 2006
Appl. No.:

11/421658
Inventors:

Joseph A. Beavo - Seattle WA, US
Thomas Seebeck - Ortschwaben, CH
Scott Haydn Soderling - Beaverton OR, US
Ana Rascon - Caracas, VE
Roya Zoraghi - Nashville TN, US
Stefan Kunz - Bern, CH
Kewei Gong - Los Angeles CA, US
Natalie Glavas - Daly City CA, US
Assignee:

University of Bern - Bern
University of Washington - Seattle WA
International Classification:

C12N 15/79
C12N 15/80
C12N 15/81
C12N 9/16
C12Q 1/68
US Classification:

435196, 4352523, 4353201, 536 232
Abstract:

The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention also include peptide nucleic acids (PNA), and antisense molecules that react with the nucleic acid molecules of the invention. The invention also relates to agonists, antibodies, antagonists or inhibitors of the activity of novel PDE proteins. These compositions are useful for the diagnosis, prevention or treatment of conditions associated with the presence or the deficiency of novel PDE proteins.

Dna Encoding Mammalian Phosphodiesterases
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US Patent:

7842478, Nov 30, 2010
Filed:

Aug 9, 2006
Appl. No.:

11/501327
Inventors:

Joseph A. Beavo - Seattle WA, US
J. Kelley Bentley - Seattle WA, US
Harry Charbonneau - West Lafayette IN, US
William K. Sonnenburg - Mountlake Terrace WA, US
Assignee:

The Board of Regents of the University of Washington - Seattle WA
International Classification:

C12P 21/06
US Classification:

435 691, 435 71, 4353201, 435325, 530350
Abstract:

The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.

Cyclic Gmp-Binding, Cyclic Gmp-Specific Phosphodiesterase Materials And Methods
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US Patent:

20030054992, Mar 20, 2003
Filed:

Apr 3, 2002
Appl. No.:

10/115515
Inventors:

Joseph Beavo - Seattle WA, US
Jackie Corbin - Nashville TN, US
Kenneth Ferguson - Bothell WA, US
Sharron Francis - Nashville TN, US
Ann Kadlecek - Seattle WA, US
Kate Loughney - Seattle WA, US
William Sonnenburg - Mountlake Terrace WA, US
Melissa Thomas - Boston MA, US
Assignee:

ICOS Corporation
International Classification:

A61K038/17
C07H021/04
C12N009/20
C12P021/02
C12N005/06
US Classification:

514/012000, 435/198000, 435/069100, 435/325000, 435/320100, 536/023200
Abstract:

The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.

Cyclic Gmp-Binding, Cyclic Gmp-Specific Phosphodiesterase Materials And Methods
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US Patent:

20050196833, Sep 8, 2005
Filed:

Jan 28, 2003
Appl. No.:

10/353575
Inventors:

Joseph Beavo - Seattle WA, US
Jackie Corbin - Nashville TN, US
Kenneth Ferguson - Bothell WA, US
Sharron Francis - Nashville TN, US
Ann Kadlecek - Madison CT, US
Kate Loughney - Seattle WA, US
William Sonnenburg - Spring TX, US
Melissa Thomas - Boston MA, US
International Classification:

C12N009/16
C07H021/04
A61K031/519
US Classification:

435069100, 435196000, 435320100, 435325000, 514252160, 536023200
Abstract:

The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding. cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.