Joseph F Bauer

US Patent:

6752986, Jun 22, 2004

Filed:

May 24, 2001

Appl. No.:

09/864747

Inventors:

Joseph A. Bauer - Akron OH
Daniel J. Lindner - Shaker Heights OH

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61K 3821

US Classification:

424 856, 514 2, 514 52, 424 854, 530351, 536 264

Abstract:

The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e. g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e. g. cobalamin drug conjugates).

US Patent:

20040220136, Nov 4, 2004

Filed:

Jan 21, 2004

Appl. No.:

10/761870

Inventors:

Joseph Bauer - Akron OH, US
Daniel Lindner - Shaker Heights OH, US

International Classification:

A61K038/19
A61K031/714
A61K038/21

US Classification:

514/052000, 424/085100, 424/085700

Abstract:

The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

US Patent:

20070104683, May 10, 2007

Filed:

Aug 28, 2006

Appl. No.:

11/511085

Inventors:

Joseph Bauer - Akron OH, US
Daniel Lindner - Shaker Heights OH, US

International Classification:

A61K 38/21
A61K 31/555
A61K 31/714

US Classification:

424085600, 514052000, 514185000

Abstract:

The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

US Patent:

20080138280, Jun 12, 2008

Filed:

Feb 19, 2004

Appl. No.:

10/546094

Inventors:

Joseph A. Bauer - Akron OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61K 31/7056
A61K 39/395
A61K 33/24
A61K 38/21
A61K 51/04
A61P 35/00

US Classification:

424 177, 514 52, 4241411, 424649, 424 856

Abstract:

The present invention is directed to compositions and methods of making and using compositions that are useful for treating cells or conditions caused or exacerbated by cell survival mechanisms of the body, particularly conditions exacerbated by cell survival mechanisms involving NF-KB. The compositions and methods of the present invention comprise a sensitizing agent or a chemopotentiating agent. In this regard, cobalamin drug conjugates and NO donors act as chemopotentiating agents. Nitrosylcobalamin is particularly useful as a sensitizing or chemopotentiating agent, and methods utilizing nitrosylcobalamin prior to, simultaneous with and subsequent to radiation or chemotherapy are described, as are compositions which first release a nitrosylcobalamin compound or biologically active analog thereof, and then release the chemotherapeutic agent. Nitrosylcobalamin itself is a chemotherapeutic, and when administered in conjunction with other anti-cancer agents or techniques, a synergistic effect is seen.

US Patent:

20100183553, Jul 22, 2010

Filed:

Dec 23, 2009

Appl. No.:

12/646249

Inventors:

Joseph A. Bauer - Akron OH, US
Daniel J. Lindner - Shaker Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61K 38/21
A61K 31/714

US Classification:

424 856, 514 52, 424 854

Abstract:

The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods of the present invention are particularly useful in enhancing the uptake or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present invention is particularly useful in the treatment or prevention of conditions that result from low expression or activity of proteins involved in the processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin or its biologically active analogs of cobalamin (e.g. cobalamin drug conjugates).

US Patent:

59360828, Aug 10, 1999

Filed:

Dec 30, 1997

Appl. No.:

9/000581

Inventors:

Joseph A. Bauer - Akron OH

Assignee:

The University of Akron - Akron OH

International Classification:

C07D48722

US Classification:

540145

Abstract:

A purified complex of a metallocorrinoid, such as a vitamin B. sub. 12 compound, and a pharmacological agent, such as nitric oxide, that is capable of site-specific delivery of the pharmacological agent in vivo. The pharmacological agent is bound to the metallocorrinoid in a non-donating solvent. The complex is then resuspended in a biocompatible medium and inserted into the recipient. The pharmacological agent then releases in vivo, especially under acidic conditions.

Author:

Joseph P. Bauer

ISBN #:

0870844512

Author:

Joseph P. Bauer

ISBN #:

0870844520

Author:

Joseph M. Bauer

ISBN #:

0470040289