Joseph M Anderberg

US Patent:

6392894, May 21, 2002

Filed:

Apr 6, 2000

Appl. No.:

09/545699

Inventors:

Kenneth F. Buechler - San Diego CA
Joseph M Anderberg - Encinitas CA
Paul H. McPherson - Encinitas CA

Assignee:

Biosite Incorporated - San Diego CA

International Classification:

H05K 500

US Classification:

361752, 361760, 361761, 361748, 361737, 439 761, 235486, 235475, 422104, 422 67, 422 99

Abstract:

A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

US Patent:

6830731, Dec 14, 2004

Filed:

Jan 5, 1998

Appl. No.:

09/003090

Inventors:

Kenneth F. Buechler - San Diego CA
Joseph M Anderberg - Encinitas CA
Paul H. McPherson - Encinitas CA

Assignee:

Biosite, Inc. - San Diego CA

International Classification:

G01N 2164

US Classification:

422 8208, 422 67, 422 8205, 702 31

Abstract:

A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

US Patent:

7416700, Aug 26, 2008

Filed:

Oct 8, 2002

Appl. No.:

10/267232

Inventors:

Kenneth F. Buechler - San Diego CA, US
Joseph M Anderberg - Encinitas CA, US
Paul H. McPherson - Encinitas CA, US

Assignee:

Biosite Incorporated - San Diego CA

International Classification:

G01N 21/64

US Classification:

422 8208, 422 8205, 422 67, 436 46, 436 50, 436172, 702 31, 600300

Abstract:

A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

US Patent:

7713703, May 11, 2010

Filed:

Nov 13, 2000

Appl. No.:

09/712615

Inventors:

Kenneth F. Buechler - San Diego CA, US
Joseph M Anderberg - Encinitas CA, US
Paul H. McPherson - Encinitas CA, US

Assignee:

Biosite, Inc. - Waltham MA

International Classification:

G01N 33/53

US Classification:

435 71, 4352831, 436 43

Abstract:

The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.

US Patent:

20020190356, Dec 19, 2002

Filed:

May 21, 2002

Appl. No.:

10/153424

Inventors:

Kenneth Buechler - San Diego CA, US
Joseph Anderberg - Encinitas CA, US
Paul McPherson - Encinitas CA, US

Assignee:

BIOSITE INCORPORATED - SAN DIEGO CA

International Classification:

H01L021/48
H01L023/495

US Classification:

257/668000, 438/123000

Abstract:

A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.

US Patent:

20040121350, Jun 24, 2004

Filed:

Apr 8, 2003

Appl. No.:

10/410572

Inventors:

Joseph Anderberg - Encinitas CA, US
Kenneth Buechler - Rancho Santa Fe CA, US
Paul McPherson - Encinitas CA, US
Howard Kirchick - San Diego CA, US
Jeffrey Dahlen - San Diego CA, US

Assignee:

Biosite Incorporated

International Classification:

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 435/007100, 702/019000

Abstract:

The present invention relates to methods and system for the diagnosis diseases or conditions. In a particular aspect, a disclosed method for determining a panel includes calculating a panel response for each patient in a set of diseased patients and in a set of non-diseased patients. The panel response is a function of the value of each of a plurality of markers in a panel of markers. The method also includes calculating a value for an objective function. The objective function is indicative of the effectiveness of the panel. The steps of calculating a panel response for each patient and calculating a value for an objective function are iterated by varying at least one of the parameters relating to the panel response function and a sense of each marker to facilitate optimization of the objective function. The objective function may be a measure of an overlap of panel responses of diseased patients and panel responses of non-diseased patients. The contribution of each marker to the objective function may be determined, and the panel size may be reduced by removing the poorest markers. Thus, an optimum panel of markers and an optimal panel response function for the diagnosis of a disease or condition may be determined.

US Patent:

20040126767, Jul 1, 2004

Filed:

Dec 27, 2002

Appl. No.:

10/331127

Inventors:

Joseph Anderberg - Encinitas CA, US
Kenneth Buechler - Rancho Santa Fe CA, US
Paul McPherson - Encinitas CA, US
Howard Kirchick - San Diego CA, US
Jeffrey Dahlen - San Diego CA, US

Assignee:

Biosite Incorporated

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50

US Classification:

435/006000, 702/020000

Abstract:

The present invention relates to methods and system for the diagnosis diseases or conditions. In a particular aspect, a disclosed method for determining a panel includes calculating a panel response for each patient in a set of diseased patients and in a set of non-diseased patients. The panel response is a function of the value of each of a plurality of markers in a panel of markers. The method also includes calculating a value for an objective function. The objective function is indicative of the effectiveness of the panel. The steps of calculating a panel response for each patient and calculating a value for an objective function are iterated by varying at least one of the parameters relating to the panel response function and a sense of each marker to facilitate optimization of the objective function. The objective function may be a measure of an overlap of panel responses of diseased patients and panel responses of non-diseased patients. The contribution of each marker to the objective function may be determined, and the panel size may be reduced by removing the poorest markers. Thus, an optimum panel of markers and an optimal panel response function for the diagnosis of a disease or condition may be determined.

US Patent:

20040241047, Dec 2, 2004

Filed:

May 7, 2004

Appl. No.:

10/841274

Inventors:

Kenneth Buechler - San Diego CA, US
Joseph Anderberg - Encinitas CA, US
Paul McPherson - Encinitas CA, US

Assignee:

Biosite, Inc.

International Classification:

G01N021/64

US Classification:

422/082080

Abstract:

A fluorometer for sensing the fluorescence of a sample utilizes an optical energy source for exciting a sample to be tested and an optical energy detector for detecting the emitted energy from the excited sample. Drive electronics are used for positioning the sample with respect to the optical components allowing a plurality of sample regions to be tested. A processor is utilized to control the operation of the test in accordance with test instructions and for processing the emitted energy detected from the sample to determine test results. A ROM chip socket accepts a plurality of ROM chips, wherein each ROM chip stores test data sets for one or more test types to be performed. ROM chips can be swapped to allow the fluorometer to be configured and reconfigured to perform a plurality of different tests. A communications interface facilitates the sharing of test information between the fluorometer and external entities.