Jose A Guevara

Author:

Jose M. Guevara

ISBN #:

0835921328

US Patent:

20040126421, Jul 1, 2004

Filed:

Oct 6, 2003

Appl. No.:

10/680062

Inventors:

Mary Turk - New York NY, US
Jose Guevara - Roosevelt Island NY, US
Alan Houghton - New York NY, US

International Classification:

A61K039/00
A61K009/127

US Classification:

424/450000, 424/185100

Abstract:

Liposomal system formed from a peptide having a ubiquitinatable region and an antigenic region, a pH-sensitive liposomal carrier; and a bilayer-associated adjuvant, such as MPL are useful as vaccine compositions. These compositions are surprisingly effective in inducing an in vivo immune response to the antigen corresponding to the antigenic region.

US Patent:

20030157534, Aug 21, 2003

Filed:

Dec 26, 2002

Appl. No.:

10/331163

Inventors:

Manuel Engelhorn - New York NY, US
Alan Houghton - New York NY, US
Jose Guevara - New York NY, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435/006000, 536/023100

Abstract:

Therapeutic libraries of minigenes encoding at least one characteristic epitope of a target antigen and degenerate variants of major histocompatability class I restricted epitopes are prepared by constructing a population of minigenes of comparable structure (that is having parallel components at each location in the minigene), each species in the population encoding at least one characteristic epitope of the target antigen and one of a plurality a degenerate variants of an MHC Class I-restricted epitope; screening the population of minigenes in an in vitro or in vivo system to confirm the induction of immunological response against the target antigen; and optionally repeating a screening step on one or more subpopulations of the minigenes to select for immunologically-effective subpopulations, which may comprise as few as a single species of the minigene construct.