Jorge D Brioni

Author:

Jorge D. Brioni

ISBN #:

0471167584

US Patent:

6645968, Nov 11, 2003

Filed:

Feb 5, 2001

Appl. No.:

09/777217

Inventors:

Robert J. Altenbach - Chicago IL
Hao Bai - San Diego CA
Jorge D. Brioni - Vernon Hills IL
William A. Carroll - Evanston IL
Murali Gopalakrishnan - Libertyville IL
Robert J. Gregg - Libertyville IL
Mark W. Holladay - Tucson AZ
Peggy P. Huang - Lake Bluff IL
John F. Kincaid - Newbury Park CA
Michael E. Kort - Lake Bluff IL
Philip R. Kym - Grayslake IL
John K. Lynch - Kenosha WI
Arturo Perez-Medrano - Grayslake IL
Henry Q. Zhang - Grayslake IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 314406

US Classification:

514256, 514275, 514311, 514313, 514353, 544322, 544327, 544329, 544332, 546162, 546172, 546305, 546306

Abstract:

Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

US Patent:

7985745, Jul 26, 2011

Filed:

Sep 28, 2007

Appl. No.:

11/863925

Inventors:

Marlon D. Cowart - Round Lake Beach IL, US
Robert J. Altenbach - Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Irene Drizin - Wadsworth IL, US
Neil Wishart - Jefferson MA, US
David J. Babinski - Dallas TX, US
Robert J. Gregg - Libertyville IL, US
Arthur A. Hancock - Libertyville IL, US
Timothy A. Esbenshade - Schaumburg IL, US
Gin C. Hsieh - Long Grove IL, US
Jorge D. Brioni - Vernon Hills IL, US
Marie P. Honore - Evanston IL, US
Lawrence A. Black - Libertyville IL, US
Chen Zhao - Libertyville IL, US
Brian D. Wakefield - Evanston IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 31/395
A61K 31/495
A61K 31/498
A61K 31/502
A61P 25/00
A61P 25/02
A61P 19/02

US Classification:

51421021, 51425214, 514267

Abstract:

This invention discloses a method of treating pain by administering histamine Hreceptor ligands and compositions comprising the same.

US Patent:

8252801, Aug 28, 2012

Filed:

Jun 3, 2010

Appl. No.:

12/793434

Inventors:

Lynne E. Rueter - Round Lake Beach IL, US
Kaitlin E. Browman - Deerfield IL, US
Jorge D. Brioni - Vernon Hills IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Timothy A. Esbenshade - Schaumburg IL, US
Gerard B. Fox - Barrington Hills IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A01N 43/54
A61K 31/4965

US Classification:

514256, 51425501

Abstract:

The invention relates to a method of administering histamine Hantagonist and an antipsychotic therapeutic agent, compositions comprising a histamine Hantagonist and an antipsychotic therapeutic agent, and a related article of manufacture.

US Patent:

20020183357, Dec 5, 2002

Filed:

Feb 17, 2000

Appl. No.:

09/507178

Inventors:

Jorge Brioni - Vernon Hills IL, US
Michael Brune - Mundelein IL, US
Steven Buckner - Wadsworth IL, US
Teodozyj Kolasa - Lake Villa IL, US
James Sullivan - Deerfield IL, US

International Classification:

A61K031/47
A01N043/42

US Classification:

514/310000

Abstract:

The following disclosure relates to a method of treating incontinence with a compound having a specific adrenoceptor profile.

US Patent:

20040048866, Mar 11, 2004

Filed:

Feb 26, 2003

Appl. No.:

10/375842

Inventors:

Teodozyj Kolasa - Lake Villa IL, US
Jorge Brioni - Vernon Hills IL, US
Vijaya Gracias - Lindenhurst IL, US
Masaki Nakane - Lake Bluff IL, US
Meena Patel - Green Oaks IL, US
Jeffrey Rohde - Evanston IL, US

International Classification:

A61K031/519
A61K031/502
A61K031/4745
A61K031/4162
C07D471/02
C07D487/02

US Classification:

514/248000, 514/262100, 514/303000, 544/236000, 544/262000, 546/118000, 514/406000, 548/361100

Abstract:

Compounds of formula (I) are novel indazoles useful for increasing cGMP levels in a mammal.

US Patent:

20080159958, Jul 3, 2008

Filed:

Dec 5, 2007

Appl. No.:

11/950560

Inventors:

Richard J. Radek - Green Oaks IL, US
R. Scott Bitner - Pleasant Prairie WI, US
Marlon D. Cowart - Round Lake Beach IL, US
Jorge D. Brioni - Vernon Hills IL, US
Timothy A. Esbenshade - Schaumburg IL, US

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

A61K 49/00

US Classification:

424 92

Abstract:

The invention relates to an in vivo method for determining the bioactivity of chemical compounds as histamine-3 receptor (HR) ligands, and provides animal models to determine such bioactivity. The invention further relates to methods for screening therapeutic compounds demonstrating a desired property, using such methods and models described.

US Patent:

20080188452, Aug 7, 2008

Filed:

Sep 28, 2007

Appl. No.:

11/863559

Inventors:

Robert J. Altenbach - Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Irene Drizin - Wadsworth IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Neil Wishart - Jefferson MA, US
David J. Babinski - Dallas TX, US
Robert J. Gregg - Libertyville IL, US
Arthur A. Hancock - Libertyville IL, US
Kathryn J. Hancock - Libertyville IL, US
Timothy A. Esbenshade - Schaumburg IL, US
Gin C. Hsieh - Long Grove IL, US
Jorge D. Brioni - Vernon Hills IL, US
Marie P. Honore - Evanston IL, US
Lawrence A. Black - Libertyville IL, US
Chen Zhao - Libertyville IL, US
Brian D. Wakefield - Vernon Hills IL, US

International Classification:

A61K 31/517
C07D 487/10
C07D 471/10
A61K 31/55
C07D 487/04
C07D 471/04
C07D 403/04
C07D 403/14
A61P 29/00
A61P 37/00
A61P 25/00
A61P 35/00

US Classification:

51421016, 544249, 51421202, 540543, 514267, 514215, 540580, 540470, 51421021

Abstract:

Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein.

US Patent:

20090221648, Sep 3, 2009

Filed:

Dec 18, 2008

Appl. No.:

12/338865

Inventors:

Lynne E. Rueter - Round Lake Beach IL, US
Gerald B. Fox - Gurnee IL, US
Kaitlin E. Browman - Deerfield IL, US
James P. Sullivan - Deerfield IL, US
Jorge D. Brioni - Vernon Hills IL, US
Marlon D. Cowart - Round Lake Beach IL, US
Ramin Faghih - Lake Forest IL, US
Gregory A. Gfesser - Lindenhurst IL, US
Kathleen H. Mortell - Chicago IL, US
Murali Gopalakrishnan - Libertyville IL, US

Assignee:

ABBOTT LABORATORIES - Abbott Park IL

International Classification:

A61K 31/465
A61P 25/00

US Classification:

514343

Abstract:

The present invention relates to compositions for treatment of cognitive deficits. Such compositions can have a nicotinic acetylcholine receptor ligand, of either α4β2 subtype or α7 nicotinic acetylcholine subtype, and a histamine-3 receptor ligand, a method of using the same, and a related article of manufacture. Combinations of such active agents with psychostimulants or monoamine reuptake inhibitors also is contemplated.