Jonathan Lee Mills

US Patent:

8337824, Dec 25, 2012

Filed:

Aug 22, 2009

Appl. No.:

12/545810

Inventors:

Detlef Albrecht - Saratoga CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

Assignee:

Relypsa, Inc. - Santa Clara CA

International Classification:

A61K 47/10
A61K 31/75
A61K 31/755
A61K 31/785
A61K 31/047
C08F 220/22
C08F 220/04
C08F 299/00
C08F 236/00
C08F 236/20
C08F 230/02

US Classification:

424 781, 526 72, 526245, 5262921, 52629295, 5262927, 5262926, 526309, 526310, 526318, 5263181, 526319, 526326, 526328, 526334, 526336, 526337, 526340, 5263402, 5263403, 526346, 526347, 5263471, 514724, 514 75, 514579, 514722, 514743

Abstract:

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20110236340, Sep 29, 2011

Filed:

Aug 22, 2009

Appl. No.:

13/060207

Inventors:

Paul Mansky - San Francisco CA, US
Detlef Albrecht - Saratoga CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

Assignee:

Relypsa, Inc. - Santa Clara CA

International Classification:

A61K 31/78
A61P 3/02
A61P 13/12
A61P 9/10

US Classification:

424 781

Abstract:

The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20130131202, May 23, 2013

Filed:

Dec 18, 2012

Appl. No.:

13/718140

Inventors:

Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

Assignee:

RELYPSA, INC. - Santa Clara CA

International Classification:

C08K 5/053

US Classification:

521 28

Abstract:

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20130189216, Jul 25, 2013

Filed:

Mar 12, 2013

Appl. No.:

13/795982

Inventors:

Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

Assignee:

RELYPSA, INC. - Redwood City CA

International Classification:

A61K 31/78

US Classification:

424 781

Abstract:

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20200289550, Sep 17, 2020

Filed:

Nov 1, 2019

Appl. No.:

16/672005

Inventors:

- St. Gallen, CH
Detlef Albrecht - Saratoga CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

International Classification:

A61K 31/78
C08F 220/22
A61K 31/7004
A61K 9/14
A61K 47/26
B01J 39/20

Abstract:

The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20180125881, May 10, 2018

Filed:

Jan 9, 2018

Appl. No.:

15/865409

Inventors:

- Redwood City CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Campbell CA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Campbell CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

International Classification:

A61K 31/78
A61K 31/7004
C08K 5/053

Abstract:

The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.

US Patent:

20170165292, Jun 15, 2017

Filed:

Feb 27, 2017

Appl. No.:

15/443664

Inventors:

- Redwood City CA, US
Detlef Albrecht - Saratoga CA, US
Michael Burdick - Los Altos CA, US
Han-Ting Chang - Livermore CA, US
Dominique Charmot - Napa CA, US
Eric Connor - Los Gatos CA, US
Sherin Halfon - Palo Alto CA, US
Mingjun Liu - Sewickley PA, US
Ramakrishnan Chidambaram - Pleasanton CA, US
Jonathan Mills - San Jose CA, US
Werner Strüver - Leverkusen, DE

International Classification:

A61K 31/78
A61K 47/26
A61K 9/14
C08F 220/22
B01J 39/20

Abstract:

The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.

Author:

Jonathan W. Mills

ISBN #:

0818674083

Author:

Jonathan W. Mills

ISBN #:

0818675144