John J Pacella

US Patent:

6808482, Oct 26, 2004

Filed:

Sep 22, 2000

Appl. No.:

09/668090

Inventors:

John J. Pacella - Pittsburgh PA
Andrew H. Goldstein - Rochester NY
Dennis R. Trumble - Pittsburgh PA
Richard E. Clark - Sewickley PA
Fred W. Moeller - McKeesport PA
George J. Magovern - Pittsburgh PA

Assignee:

Allegheny-Singer Research Institute - Pittsburgh PA

International Classification:

A61M 110

US Classification:

600 16

Abstract:

A blood pump device comprises a blood pump having blood transport ports, cannulae connected to the ports, and a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. Also included is a method for producing a smooth coating. The blood pump device comprises a second portion including a stator mechanism, a rotor mechanism, an impeller, a journal, and a seat member. The second portion is constructed to pump blood through the cannulae when power is provided. The blood pump device is also equipped with a safety occluder device, a sensor for detecting back emf in the stator mechanism, and a controller having the capability of indicating stator current and rotor speed.

US Patent:

20050004421, Jan 6, 2005

Filed:

Jul 16, 2004

Appl. No.:

10/892656

Inventors:

John Pacella - Pittsburgh PA, US
Andrew Goldstein - Branford CT, US
Dennis Trumble - Pittsburgh PA, US
Richard Clark - Sewickley PA, US
Fred Moeller - McKeesport PA, US
George Magovern - Pittsburgh PA, US

International Classification:

A61N001/362

US Classification:

600016000

Abstract:

The present invention pertains to a blood pump device which comprises a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also comprises a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. The invention is also related to a method of producing a smooth coating. The present invention is a blood pump device comprising a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a one-piece seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. The present invention is also related to means for providing power to the blood pump so that blood can be pumped through a cannulae. The providing means includes a controller having means for sensing pump failure and an output terminal for actuating a safety occluder in an event of pump failure. Preferably, there is a safety occluder device disposed about the cannulae and in communication with the output terminal. Preferably, the blood pump comprises a motor having stator mechanism and a rotor mechanism driven by the stator mechanism. The sensing means comprises means for determining back electromagnetic force within the stator mechanism. Preferably, the controlling means has means for providing signals indicate of stator current and rotor speed, respectively. The providing means is in communication with the means for determining back electromagnetic force in the stator mechanism.

US Patent:

20100152526, Jun 17, 2010

Filed:

Dec 31, 2009

Appl. No.:

12/655492

Inventors:

John J. Pacella - Pittsburgh PA, US
Andrew H. Goldstein - Branford CT, US
Dennis R. Trumble - Pittsburgh PA, US
Richard E. Clark - Sewickley PA, US
Fred W. Moeller - McKeesport PA, US
George J. Magovern - Pittsburgh PA, US

International Classification:

A61M 1/10

US Classification:

600 17

Abstract:

A pumping system for blood for a patient includes a sensorless pump having no sensors disposed in the pump itself for moving the blood, a motor and a blood transport port through which blood is received from the patient and is pumped into the patient. The system also includes a controller connected to the pump for controlling the pump so a desired flow rate of blood can be maintained by the pump.

US Patent:

60454962, Apr 4, 2000

Filed:

Apr 15, 1994

Appl. No.:

8/228150

Inventors:

John J. Pacella - Pittsburgh PA
Richard E. Clark - Sewickley PA

Assignee:

Allegheny-Singer Research Institute - Pittsburgh PA

International Classification:

A61F 200

US Classification:

600 16

Abstract:

The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. The bladder mechanism preferably comprises a bladder and means for inflating the bladder.

US Patent:

57117535, Jan 27, 1998

Filed:

Mar 18, 1996

Appl. No.:

8/618084

Inventors:

John J. Pacella - Pittsburgh PA
Andrew H. Goldstein - Rochester NY
Dennis R. Trumble - Pittsburgh PA
Richard E. Clark - Sewickley PA
Fred W. Moeller - McKeesport PA

Assignee:

Allegheny-Singer Research Institute - Pittsburgh PA

International Classification:

A61M 112

US Classification:

600 16

Abstract:

The present invention pertains to a blood pump device which comprises a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also comprises a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. The invention is also related to a method of producing a smooth coating. The present invention is a blood pump device comprising a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a one-piece seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal.

US Patent:

61621676, Dec 19, 2000

Filed:

Jul 21, 1997

Appl. No.:

8/898584

Inventors:

Andrew H. Goldstein - Branford CT
John J. Pacella - Pittsburgh PA
Dennis R. Trumble - Pittsburgh PA
Richard E. Clark - Sewickley PA
Fred W. Moeller - McKeesport PA
George J. Magovern - Pittsburgh PA

Assignee:

Allegheny-Singer Research Institute - Pittsburgh PA

International Classification:

A61M 112

US Classification:

600 16

Abstract:

A blood pump device which includes a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also includes a coating material covering the junction between the inner surfaces of the ports and cannulae. A method of producing a smooth coating. A blood pump device including a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. A mechanism for providing power to the blood pump so that blood can be pumped through a cannula.

US Patent:

61861499, Feb 13, 2001

Filed:

Mar 13, 2000

Appl. No.:

9/524647

Inventors:

John J. Pacella - Pittsburgh PA
Richard E. Clark - Sewickley PA

Assignee:

Allegheny-Singer Research Institute - Pittsburgh PA

International Classification:

A61M 112

US Classification:

128898

Abstract:

The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. Type bladder mechanism preferably comprises a bladder and means for inflating the bladder.

US Patent:

20230065014, Mar 2, 2023

Filed:

Jan 14, 2021

Appl. No.:

17/792653

Inventors:

- Pittsburgh PA, US
Bruce A. Freeman - Pittsburgh PA, US
Flordeliza S. Villanueva - Pittsburgh PA, US
John J. Pacella - Bethel Park PA, US
Marco Fazzari - Pittsburgh PA, US
Xucai Chen - Pittsburgh PA, US

International Classification:

A61K 9/50
A61K 47/10
A61K 47/24
A61K 31/19
A61P 9/10

Abstract:

Provided herein are microbubble compositions comprising nitro-fatty acids and/or esters thereof, such as amphiphilic esters or allyl esters thereof. Also provided are methods of reducing local inflammation at a site in a patient comprising delivering the microbubbles to a site of inflammation in the patient and applying ultrasound to the microbubbles. The methods may be used to treat fibrosis or cancer.