Compounds represented by the formula: wherein A is selected from the group consisting of W is NH or H; and each X, Y and Z is individually selected from the group consisting of OH, H and halogen provided at least one of X and Y is H; tautomers, or pharmaceutically acceptable salts thereof; are provided. Compounds of the present invention are useful as inhibitors of PNP and of T-cell proliferation. Compounds of the present invention are useful for treating Cancer. Method for preparing the compounds of the present invention are also provided.
Substituted Cyclopentane Compounds Useful As Neuraminidase Inhibitors
Yarlagadda S. Babu - Birmingham AL Pooran Chand - Birmingham AL John A. Montgomery - Birmingham AL
Assignee:
Biocryst Pharmaceuticals, Inc. - Birmingham AL
International Classification:
A61K 31235
US Classification:
514563, 514613, 514635, 562504, 564 32, 564193
Abstract:
Compounds represented by formula (I), and pharmaceutically acceptacle salts thereof; and their method of preparation are provided. Compounds of the above formula are influenza virus neuraminidase inhibitors and can be used in treating patients infected with influenza virus.
Deazaguanine Analog, Preparation Thereof And Use Thereof
1-C-(9-deazaaden-9-yl)-1,4-imino-D-5â-deoxy-5â-methylthioribitol) and pharmaceutically acceptable salts thereof are useful for inhibiting MTAP and treating cancer. A method for preparing the compounds of the present invention is also provided.
Substituted Pyrrolidine Compounds Useful As Neuraminidase Inhibitors
Pooran Chand - Birmingham AL Pravin L. Kotian - Birmingham AL Yarlagadda S. Babu - Birmingham AL John A. Montgomery - Birmingham AL
Assignee:
BioCryst Pharmaceuticals, Inc. - Birmingham AL
International Classification:
A61K 3140
US Classification:
514423, 548531
Abstract:
Certain substituted pyrrolidine compounds, pharmaceutically acceptable salts thereof, and their method of preparation are disclosed as well as use as influenza virus neuraminidase inhibitors.
Substituted Cyclopentane And Cyclopentene Compounds Useful As Neuraminidase Inhibitors
Kamal N. Tiwari - Birmingham AL John A. Montgomery - Birmingham AL
Assignee:
Southern Research Institute - Birmingham AL
International Classification:
A61K 900
US Classification:
514 49, 514 43
Abstract:
Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; A is selected from the group consisting of wherein X is selected from the group consisting of hydrogen, fluorine, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano and nitro. The above compounds also inhibit DNA replication in mammalian cells,.
Shanta Bantia - Birmingham AL John A. Montgomery - Birmingham AL George A. Omura - Birmingham AL
Assignee:
Biocryst Pharmaceuticals, Inc. - Birminghan AL
International Classification:
A61K 31505
US Classification:
514 43, 514 45, 51425931, 514885, 514922
Abstract:
Enhancement of T-cell proliferation in a host inhibition is provided by administering 2â-deoxyguanosine and/or prodrug thereof and a PNP inhibitor. The PNP inhibitor has a Ki value of 50 nanomoles or less.
Shanta Bantia - Birmingham AL John A. Montgomery - Birmingham AL
Assignee:
BioCryst Pharmaceuticals Inc. - Birmingham AL
International Classification:
A61K 3170
US Classification:
514 43, 514 45
Abstract:
T-cell inhibition proliferation in a mammalian host by administering effective amounts of 2â-deoxyguanosine and/or prodrugs thereof; and certain PNP inhibitors.
Dr. Montgomery graduated from the Indiana University School of Medicine in 1990. He works in Columbus, IN and specializes in Pediatrics and Adolescent Medicine. Dr. Montgomery is affiliated with Columbus Regional Health.
Dr. Montgomery graduated from the University of Texas Southwestern Medical Center at Dallas in 1961. He works in Price, UT and specializes in Psychiatry. Dr. Montgomery is affiliated with Castleview Hospital.
University Hospital Emergency Medicine 1 Hospital Dr Dc029, Columbia, MO 65212 573 882-8091 (phone), 573 884-1902 (fax)
Education:
Medical School Universidad Autu00F3noma de Guadalajara, Guadalajara, Jalisco, Mexico Graduated: 1979
Languages:
English Spanish
Description:
Dr. Montgomery graduated from the Universidad Autu00F3noma de Guadalajara, Guadalajara, Jalisco, Mexico in 1979. He works in Columbia, MO and specializes in Emergency Medicine. Dr. Montgomery is affiliated with University Hospital and Womens & Childrens Hospital.
"We're excited and relieved [to return to the U.S.]," John Montgomery, a passenger on the Diamond Princess, told NPR. "The fact that we're going back to the United States to have a quarantine, we feel there's a much better situation."
The comedy is produced in-house by CBS Television Studios and expands CBS' relationship with Bob Daily, showrunner on The Odd Couple. Exec producers include Neil Goldman, Garrett Donovan, Mark Teitelbaum, John Montgomery, Michael Rotenberg, Josh Lieberman and Fowler. James Burrows directed the pilot
Date: Sep 21, 2016
Category: Entertainment
Source: Google
CBS Greenlights 'Superior Donuts' for Midseason Debut
Fowler will serve as exec producer on Superior Donuts, along withBob Daily, Neil Goldman, Garrett Donovan, Mark Teitelbaum, John Montgomery, Michael Rotenberg and Josh Lieberman. CBS Television Studios is producing.
Date: Sep 21, 2016
Category: Entertainment
Source: Google
1986 Masters: Nicklaus defies Father Time with a win for the ages
John Montgomery, a Nicklaus friend and business partner who reveled in playing pranks on Jack, made certain to tape that uncomplimentary clipping on the refrigerator door at the house the family was renting for the week.
Date: Apr 04, 2016
Category: Sports
Source: Google
Cal to face familiar friend in Hawaii assistant Montgomery
Former Cal player Theo Robertson, who played when John Montgomery was working in the basketball office and is now on the Golden State Warriors staff, has plenty of interest in seeing how the Bears fare against the Hawaii team run by Ganot and Montgomery.
Date: Mar 17, 2016
Category: Sports
Source: Google
Police: Valuable violins stolen, then resold in N. Carolina
Fields and Crouse had sold violins to a shop owned by John Montgomery in Raleigh, North Carolina, in recent months, but the manner in which they presented the instruments and the stories they gave made Montgomery suspicious. When he researched the violins, which are hand-crafted and have unique char
Date: Jun 12, 2015
Category: U.S.
Source: Google
GroupM On Apple Inc.'s Mobile Ad Blocker 'We'd Never Say It's Not A Threat'
Its something were looking at really carefully, said John Montgomery, COO of GroupM North America, the U.S. unit of the biggest ad spender in the world. Wed never say its not a threat. What we know about the ecosystem is the vast majority of users coming into the online space want things for
Finally, there's Silver-rated Bridgeway Blue Chip 35 , managed by John Montgomery and his team at Bridgeway. Unlike managers who use fundamentals and valuation to try to identify the most attractive stocks, the Bridgeway team simply ranks the 150 largest U.S. stocks by market capitalization, then b
Date: Apr 30, 2015
Category: Business
Source: Google
Googleplus
John Montgomery
Work:
Baxter County Sheriff's Office - Sheriff (2005) Mountain Home Police Department - Lieutenant (1988-2003) Montgomery Central Systems - Owner (1995-2010)
Education:
Arkansas State University Mountain Home - Criminal Justice, West Plains High School
Tagline:
Sheriff of Baxter County, Arkansas
John Montgomery
Work:
Math Crazy - Tutor (2012) Santé Health System - Intern (2009-2011)
Education:
Fresno City College, Edison High School
Tagline:
NANANANANANANANA BATMAN
John Montgomery
Work:
Self employed
Education:
Kristin School
About:
I am cool
Tagline:
Yo
John Montgomery
Work:
Mosaico Travel Services - Principal (2006)
About:
John is the principal and owner of Mosaico Travel Services, which he founded in 2006. Mosaico Travel Services delivers the finest in custom travel to Central America and South America. Latin American ...
Tagline:
Principal, Mosaico Travel Services
John Montgomery
Work:
Empire Review Magazine
Education:
Texas A & I
About:
Born in Corpus Christi, and spent high school years in Falfurrias, Texas.
Bragging Rights:
Editor of corporate magazines in past. Now producer of Texas magazine
John Montgomery
Work:
UTest, Inc - VP of Delivery (9)
Education:
Texas A&M University - Management
John Montgomery
Lived:
Birmingham, Alabama
Work:
Big Communications, Inc. - President
Education:
University of Alabama at Birmingham
John Montgomery
Education:
Louisiana Tech University - History, East Texas Baptist University - History