John E Mccarty

US Patent:

20070071806, Mar 29, 2007

Filed:

Feb 24, 2004

Appl. No.:

10/545774

Inventors:

John McCarty - Miami Springs FL, US

International Classification:

A61K 38/22
A61K 38/12
A61K 9/12
A61K 31/727
A61K 31/675
A61K 31/663
A61K 31/60
A61K 31/485
A61K 31/48
A61K 31/4745
A61K 31/535
A61K 31/5377
A61K 31/522
A61K 31/515

US Classification:

424451000, 424464000, 424045000, 514165000, 514056000, 514535000, 514263310, 514282000, 514649000, 514290000, 514291000, 514235500, 514304000, 514009000, 514089000, 514102000, 514012000, 514573000, 514317000, 514192000, 514288000, 514270000, 514217000, 514342000

Abstract:

Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent and a lipophilic species having ionic characteristics opposite to that of the pharmaceutical agent. Such lipophilic associations manifest high thermodynamic activity, as evidenced by their being predominantly in a liquid phase at room temperature or solvated in a lower-than-water dielectric solvent. Further the pharmaceutical agent being solubilized means that dissolution is not rate limiting to transmucosal absorption. This LA or LA-solvate is formulated into a low dielectric dosage form, from whence, upon the dosage form's hydration, the pharmaceutical agent is driven through the mucosal tissue and into systemic circulation. The invention therefore provides an enhanced transmucosal drug delivery system for ionizable pharmaceutical agents at or near physiological pH.

US Patent:

20100119601, May 13, 2010

Filed:

Apr 10, 2008

Appl. No.:

12/595183

Inventors:

John A. McCarty - Miami Springs FL, US

Assignee:

PHARMACEUTICAL PRODUCTIONS INC. - Miami Springs FL

International Classification:

A61K 31/4045
A61K 9/20
A61K 9/14
A61K 31/56
A61P 25/28
A61P 35/00

US Classification:

424464, 424490, 514171, 514419

Abstract:

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

US Patent:

20130028943, Jan 31, 2013

Filed:

Oct 3, 2012

Appl. No.:

13/633924

Inventors:

John A. McCARTY - Miami Springs FL, US

International Classification:

A61K 31/4045
A61P 25/28
B05D 5/00
A61P 25/00
A61P 39/06
A61K 9/14
A61P 35/00

US Classification:

424400, 514415, 427 214

Abstract:

The present invention provides a pharmaceutical composition for sublingual or buccal administration of actives with low to poor aqueous solubility, e.g. the indole hormone melatonin, which contains a solution of the active in a pharmaceutically acceptable solvent adsorbed or absorbed onto particles of a pharmaceutically acceptable carrier and methods of preparing and using the pharmaceutical composition.

US Patent:

59520043, Sep 14, 1999

Filed:

Aug 28, 1995

Appl. No.:

8/424521

Inventors:

Edward Rudnic - No. Potomac MD
John McCarty - Biscayne Park FL
Beth Burnside - Silverspring MD
Charlotte McGuinness - Rockville MD
George Belenduik - Potomac MD

Assignee:

Shire Laboratories Inc. - Rockville MD

International Classification:

A61K 966
A61K 948

US Classification:

424455

Abstract:

A pharmaceutical preparation comprising a stable, surface-active emulsion or dispersion of a pharmaceutical agent incorporated into an emulsion (i) having a hydrophobic discontinuous phase of a long chain carboxylic acid or ester or alcohol thereof dispersed in an aqueous phase or (ii) having a hydrophilic discontinuous phase dispersed in a hydrophobic phase of a long chain carboxylic acid or alcohol thereof. The emulsion with pharmaceutical agent is incorporated into a pharmaceutical carrier suitable for oral delivery.

US Patent:

51126168, May 12, 1992

Filed:

Oct 8, 1991

Appl. No.:

7/773183

Inventors:

John A. McCarty - Biscayne Park FL

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 920
A61K 4700

US Classification:

424435

Abstract:

A fast dissolving buccal tablet for administering a medicament includes the active ingredient, a lubricant and a water soluble sugar, such as sorbitol, combined such that the buccal tablet dissolves in about one minute.

US Patent:

50733745, Dec 17, 1991

Filed:

Nov 30, 1988

Appl. No.:

7/278099

Inventors:

John A. McCarty - Biscayne Park FL

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 920
A61K 4700

US Classification:

424435

Abstract:

A fast dissolving buccal tablet for administering a medicament includes the active ingredient, a lubricant and a water soluble sugar, such as sorbitol, combined such that the buccal tablet dissolves in about one minute.

US Patent:

54846080, Jan 16, 1996

Filed:

Mar 28, 1994

Appl. No.:

8/218757

Inventors:

Edward M. Rudnic - No. Potomac MD
John A. McCarty - Biscayne Park FL
George W. Belenduik - Potomac MD

Assignee:

Pharmavene, Inc. - Rockville MD

International Classification:

A61K 922
A61K 924
A61K 926

US Classification:

424468

Abstract:

A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created in a hydrophobic matrix by incorporating hydrophilic polymers within a hydrophobic matrix. Optionally, a binder, preferably a polyhydroxylated compound, ca also be added.

US Patent:

54300215, Jul 4, 1995

Filed:

Mar 18, 1994

Appl. No.:

8/210014

Inventors:

Edward M. Rudnic - No. Potomac MD
John A. McCarty - Biscayne Park FL
George W. Belenduik - Potomac MD

Assignee:

Pharmavene, Inc. - Gaithersburg MD

International Classification:

A61K 914
A61K 3702

US Classification:

514 14

Abstract:

A pharmaceutical preparation including a drug incorporated into hydrophobic particles comprised of long chain carboxylic acid or ester thereof or long chain alcohol, wherein the particles are incorporated into a unit dosage form and are individually coated with an enteric coating and/or the unit dosage form includes an enteric protective material.

Author:

John Lawton McCarty

ISBN #:

0806120894

Author:

John McCarty

ISBN #:

0306813017

Author:

John McCarty

ISBN #:

0306814293

Author:

John McCarty

ISBN #:

0312017103

Author:

John McCarty

ISBN #:

0312017111

Author:

John McCarty

ISBN #:

0312017847

Author:

John McCarty

ISBN #:

0312029586

Author:

John McCarty

ISBN #:

0312070462