John Hardy Fitchen

Author:

John Fitchen

ISBN #:

0226252035

Author:

John Fitchen

ISBN #:

0262061023

Author:

John Fitchen

ISBN #:

0815606907

Author:

John Fitchen

ISBN #:

0815621264

US Patent:

20100198101, Aug 5, 2010

Filed:

Sep 24, 2008

Appl. No.:

12/679730

Inventors:

Xubo Song - Portland OR, US
Martin Fuss - Portland OR, US
K. Jeffrey Eriksen - Portland OR, US
Deniz Erdogmus - Portland OR, US
Mark Deffebach - Portland OR, US
Darryl Kaurin - Portland OR, US
John Holland - Portland OR, US
John Fitchen - Portland OR, US

International Classification:

A61B 5/053

US Classification:

600547

Abstract:

Embodiments herein provide a non-invasive tracking system that accurately predicts the location of tumors, such as lung tumors, in real time, while allowing patients to breathe naturally. This is accomplished by using Electrical Impedance Tomography (EIT), in conjunction with spirometry, strain gauge and infrared sensors, and by using sophisticated patient-specific mathematical models that incorporate the dynamics of tumor motion. With the direction and speed of lung tumor movement successfully tracked, radiation may be effectively delivered to the lung tumor and not to the surrounding healthy tissue, thus increased radiation dosage may be directed to improving local tumor control without compromising functional parenchyma.

US Patent:

48206920, Apr 11, 1989

Filed:

Jan 9, 1987

Appl. No.:

7/001778

Inventors:

Michael K. Riscoe - Tualatin OR
John H. Fitchen - Portland OR
Adolph J. Ferro - Corvallis OR

Assignee:

State of Oregon, acting by and through the Oregon State Board of Higher
Education, acting for and on behalf of the Oregon Health Sciences
University and Oregon State University - Portland OR

International Classification:

A61K 3170
C07H 1500
C07H 1504
C12P 1312

US Classification:

514 23

Abstract:

Compounds of the formula: ##STR1## wherein R is H, Cl, F, Br, I or R. sub. 1 S--, in which R. sub. 1 is C. sub. 1 -C. sub. 10 linear or branched chain alkyl or halogenated linear or branched chain alkyl, and wherein R. sub. 2, R. sub. 3 and R. sub. 4 are the same or different and each is H-- or --OH, with the proviso that at least one of R. sub. 2, R. sub. 3 and R. sub. 4 is hydroxy and the further proviso that when R. sub. 2, R. sub. 3 and R. sub. 4 are all OH, R. sub. 1 is other than methyl, are useful in inhibiting the growth of MTR kinase-dependent microorganisms and parasitic protazoans. The compounds wherein R is R. sub. 1 S are novel, except those wherein R. sub. 1 is methyl or isobutyl when R. sub. 2, R. sub. 3 and R. sub. 4 are all OH.