John W Dankwardt

US Patent:

7820704, Oct 26, 2010

Filed:

Apr 20, 2005

Appl. No.:

11/110499

Inventors:

Adnan M. M. Mjalli - Jamestown NC, US
Bapu R. Gaddam - Greensboro NC, US
Ghassan Qabaja - High Point NC, US
Govindan Subramanian - High Point NC, US
Jeff Zhu - Greensboro NC, US
John Dankwardt - Westborough MA, US
Murty N. Arimilli - Oak Ridge NC, US
Robert C. Andrews - Jamestown NC, US
Samuel Victory - Oak Ridge NC, US
Ye E. Tian - Jamestown NC, US

Assignee:

TransTech Pharma, Inc. - High Point NC

International Classification:

A61K 31/427
A61K 31/381
C07D 277/38
C07D 409/12

US Classification:

514370, 514444, 548194, 549 59

Abstract:

The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

US Patent:

20050010073, Jan 13, 2005

Filed:

Jul 8, 2003

Appl. No.:

10/615810

Inventors:

John Dankwardt - Greenville NC, US

Assignee:

DSM IP Assets B.V. - Het Overloon 1

International Classification:

C07C001/00
C07C002/86

US Classification:

585469000, 585454000

Abstract:

The present invention provides nickel catalysts and solvents which are useful in a cross-coupling reaction between an organomagnesium compound and an aromatic ether compound, such as an anisole derivative.

US Patent:

20060240976, Oct 26, 2006

Filed:

Jun 21, 2006

Appl. No.:

11/472068

Inventors:

John Dankwardt - Westborough MA, US

International Classification:

B01J 31/00

US Classification:

502150000, 502152000, 502155000, 502162000

Abstract:

The present invention provides nickel catalysts and solvents which are useful in a cross-coupling reaction between an organomagnesium compound and an aromatic ether compound, such as an anisole derivative.