Joseph G Gitchell

US Patent:

6893654, May 17, 2005

Filed:

Mar 18, 2002

Appl. No.:

10/098307

Inventors:

John M. Pinney - Bethesda MD, US
Jack E. Henningfield - Baltimore MD, US
Saul Shiffman - Pittsburgh PA, US
Joseph Gitchell - Bethesda MD, US
Edward J. Cone - Severna Park MD, US

Assignee:

JSR, LLC - Bethesda MD

International Classification:

A61F013/00
A61K009/48
A61K009/14
A61K009/20

US Classification:

424434, 424451, 424489, 424464, 424 48, 424484

Abstract:

A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e. g.

US Patent:

8642016, Feb 4, 2014

Filed:

Jul 20, 2007

Appl. No.:

11/878163

Inventors:

Tommy L. Chau - Ashburn VA, US
John M. Pinney - St. Michaels MD, US
Jack E. Henningfield - Baltimore MD, US
Edward J. Cone - Severna Park MD, US
Saul M. Shiffman - Pittsburgh PA, US
Joseph G. Gitchell - Chevy Chase MD, US

Assignee:

JSRNTI, LLC - Bethesda MD

International Classification:

A61K 9/68

US Classification:

424 48

Abstract:

A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.

US Patent:

20020018800, Feb 14, 2002

Filed:

Sep 3, 1998

Appl. No.:

09/146696

Inventors:

JOHN M. PINNEY - BETHESDA MD, US
JACK E. HENNINGFIELD - BALTIMORE MD, US
SAUL SHIFFMAN - PITTSBURGH PA, US
JOSEPH GITCHELL - BETHESDA MD, US
EDWARD J. CONE - SEVERNA PARK MD, US

International Classification:

A61F013/00

US Classification:

424/435000, 424/434000

Abstract:

A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.

US Patent:

20050214229, Sep 29, 2005

Filed:

May 16, 2005

Appl. No.:

11/129323

Inventors:

John Pinney - Bethesda MD, US
Jack Henningfield - Baltimore MD, US
Saul Shiffman - Pittsburgh PA, US
Joseph Gitchell - Bethesda MD, US
Edward Cone - Severna Park MD, US

International Classification:

A61K031/4439
A61K009/68
A61K009/20

US Classification:

424048000, 424464000, 514343000

Abstract:

A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user's mouth to facilitate absorption of the medicine when the delivery system is placed in the user's mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.

US Patent:

20210093563, Apr 1, 2021

Filed:

Oct 13, 2020

Appl. No.:

17/069303

Inventors:

- Bethesda MD, US
John M. PINNEY - St. Michael's MD, US
Jack E. HENNINGFIELD - Baltimore MD, US
Edward J. CONE - Severna Park MD, US
Saul M. SHIFFMAN - Pittsburgh PA, US
Joseph G. GITCHELL - Chevy Chase MD, US

International Classification:

A61K 9/68
A61K 9/00
A61K 31/4406
A61K 31/465

Abstract:

A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.

US Patent:

20140154301, Jun 5, 2014

Filed:

Feb 4, 2014

Appl. No.:

14/172604

Inventors:

- Bethesda MD, US
John M. PINNEY - St. Michael's MD, US
Jack E. HENNINGFIELD - Baltimore MD, US
Edward J. CONE - Severna Park MD, US
Saul M. SHIFFMAN - Pittsburgh PA, US
Joseph G. GITCHELL - Chevy Chase MD, US

Assignee:

JSRNTI, LLC - Bethesda MD

International Classification:

A61K 9/68
A61K 31/465
A61K 9/00

US Classification:

424440, 514343

Abstract:

A method is provided of making a medicinal delivery system which satiates a craving in an individual when the medicinal delivery system is administered orally to the individual. A coating composition is applied on a saliva-soluble powder to establish a coated powder, the coating composition featuring an at least partially solubilized craving satiation medicinal compound. The coated powder is combined with an edible carrier base to establish a medicinal delivery system that rapidly releases medicine and buffer preferably followed by slower, sustained release.